Selenium speciation in human serum and its implications for epidemiologic research: a cross-sectional study

Vinceti, Marco; Grill, Peter; Malagoli, Carlotta; Filippini, Tommaso; Storani, Simone; Malavolti, Marcella; Michalke, Bernhard

doi:10.1016/j.jtemb.2015.02.001

Cited by 68 publications

(52 citation statements)

References 86 publications

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“…Unfortunately, very few observational studies have addressed this issue [246], possibly due to the complexity and costs associated with the analytical procedures [247,248]. Such different effects of the various Se compounds and the associated potential for misclassification of exposure in observational studies may also be a key factor explaining their inconsistent results, in addition to unmeasured confounding [13,249,250].…”

Section: Reassessing the Safe Range Of Se Exposurementioning

confidence: 99%

Selenium and Human Health: Witnessing a Copernican Revolution?

Jabłońska

Vinceti

2015

Journal of Environmental Science and Health, Part C

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134

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In humans, selenium was hypothesized to lower the risk of several chronic diseases, mainly due to the antioxidant activity of selenium-containing proteins. Recent epidemiologic and laboratory Downloaded by [New York University] at 16:24 19 June 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2studies, however, are changing our perception of the biological effects of this nutritionally essential trace element. We reviewed the most recent epidemiologic and biochemical literature on selenium, synthesizing the findings from these studies into a unifying view. Randomized trials have shown that selenium did not protect against cancer and other chronic diseases, but even increased the risk of specific neoplasms such as advanced prostate cancer and skin cancer, in addition to type 2 diabetes. Biochemical studies indicate that selenium may exert a broad pattern of toxic effects at unexpectedly low concentrations. Furthermore, its upregulation of antioxidant proteins (selenium-dependent and selenium-independent) may be a manifestation of self-induced oxidative stress. In conclusion, toxic effects of selenium species occur at lower concentrations than previously believed. Those effects may include a large range of proteomic changes and adverse health effects in humans. Since the effects of environmental exposure to this element on human health still remain partially unknown, but are potentially serious, the toxicity of selenium exposure should be further investigated and considered as a public health priority.

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Section: Reassessing the Safe Range Of Se Exposurementioning

confidence: 99%

Selenium and Human Health: Witnessing a Copernican Revolution?

Jabłońska

Vinceti

2015

Journal of Environmental Science and Health, Part C

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134

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“…We have described elsewhere the methodology for the recruitment of the study population (Vinceti et al, 2015a). Briefly, we recruited a random sample of fifty residents in the Modena municipality located in the Emilia-Romagna region (around 180,000 inhabitants), to investigate exposure to selenium and Cd in this community.…”

Section: Study Participantsmentioning

confidence: 99%

Determinants of serum cadmium levels in a Northern Italy community: A cross-sectional study

Filippini

Michalke

Malagoli

et al. 2016

Environmental Research

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“…However, it appears unlikely that environmental exposure to selenium species induced differences as large as those that we detected between ALS patients and controls in CSF. In fact, the only biomarker of human exposure to single selenium species for which evidence is available, i.e., the serum levels of these compounds, appears to be either slightly or not influenced by factors such as age, body mass index, the use of dietary supplements, and smoking [42]. In addition, in the Italian population the consumption of such supplements appears to be rare [42] and the dietary selenium intake tends to be rather homogeneous [43].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the only biomarker of human exposure to single selenium species for which evidence is available, i.e., the serum levels of these compounds, appears to be either slightly or not influenced by factors such as age, body mass index, the use of dietary supplements, and smoking [42]. In addition, in the Italian population the consumption of such supplements appears to be rare [42] and the dietary selenium intake tends to be rather homogeneous [43]. We also geocoded in a geographical information system the addresses (current and historical) of the patients and controls included in the present study; this allowed us to rule out a previous exposure to drinking water with an unusually high (inorganic) selenium content distributed in the city of Reggio Emilia, near Modena [13,44], while the selenium content in the tapwater distributed in Italy is always very low [45].…”

Section: Discussionmentioning

confidence: 99%

Elevated Levels of Selenium Species in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients with Disease-Associated Gene Mutations

Mandrioli¹,

Michalke

Solovyev

et al. 2017

Neurodegener Dis

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Background: Although an increasing role of genetic susceptibility has been recognized, the role of environmental risk factors in amyotrophic lateral sclerosis (ALS) etiology is largely uncertain; among neurotoxic chemicals, epidemiological and biological plausibility has been provided for pesticides, the heavy metal lead, the metalloid selenium, and other persistent organic pollutants. Selenium involvement in ALS has been suggested on the basis of epidemiological studies, in vitro investigations, and veterinary studies in which selenium induced a selective toxicity against motor neurons. Objective: Hypothesizing a multistep pathogenic mechanism (genetic susceptibility and environmental exposure), we aimed to study selenium species in ALS patients carrying disease-associated gene mutations as compared to a series of hospital controls. Methods: Using advanced analytical techniques, we determined selenium species in cerebrospinal fluid sampled at diagnosis in 9 ALS patients carrying different gene mutations (C9ORF72, SOD1, FUS, TARDBP, ATXN2, and TUBA4A) compared to 42 controls. Results: In a patient with the tubulin-related TUBA4A mutation, we found highly elevated levels (in μg/L) of glutathione-peroxidase-bound selenium (32.8 vs. 1.0) as well as increased levels of selenoprotein-P-bound selenium (2.4 vs. 0.8), selenite (1.8 vs. 0.1), and selenate (0.9 vs. 0.1). In the remaining ALS patients, we detected elevated selenomethionine-bound selenium levels (0.38 vs. 0.06). Conclusions: Selenium compounds can impair tubulin synthesis and the cytoskeleton structure, as do tubulin-related gene mutations. The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset, though unmeasured confounding cannot be excluded. The elevated selenomethionine levels in the other patients are also of interest due to the toxicity of this nonphysiological selenium species. Our study is the first to assess selenium exposure in genetic ALS, suggesting an interaction between this environmental factor and genetics in triggering disease onset.

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Selenium speciation in human serum and its implications for epidemiologic research: a cross-sectional study

Cited by 68 publications

References 86 publications

Selenium and Human Health: Witnessing a Copernican Revolution?

Selenium and Human Health: Witnessing a Copernican Revolution?

Determinants of serum cadmium levels in a Northern Italy community: A cross-sectional study

Elevated Levels of Selenium Species in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients with Disease-Associated Gene Mutations

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