Abstract:Mice fed a diet deficient in Se show reduced resistance to a secondary infection with H. polygyrus. IL‐4 and IL‐13 dependent increases in intestinal smooth muscle hyper‐contractility and decreased glucose absorption correlate with expulsion of the adult worm following a challenge infection. Selenium deficiency, however, does not affect local intestinal gene expression for IL‐4 and IL‐13 or associated changes in smooth muscle and epithelial cell function. This suggests another protective mechanism compromised b… Show more
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