Selenium-Related Transcriptional Regulation of Gene Expression

Qu, Chengjuan

doi:10.20944/preprints201808.0087.v1

Cited by 16 publications

(6 citation statements)

References 91 publications

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“…Moreover, it exhibits anti-inflammatory properties [ 41 ] and supports the progression of the cell cycle, making it essential for optimal immune response [ 42 ]. Selenium influences gene expression and cell growth by activating transcription factors [ 43 ]. The chemical form of selenium is an important factor influencing biological activity.…”

Section: Selenium As An Elementmentioning

confidence: 99%

Selenium in the Prevention of SARS-CoV-2 and Other Viruses

Kieliszek

2022

Biol Trace Elem Res

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The rapid spread of new pathogens (SARS-CoV-2 virus) that negatively affect the human body has huge consequences for the global public health system and the development of the global economy. Appropriate implementation of new safety regulations will improve the functioning of the current model supervising the inhibition of the spread of COVID-19 disease. Compliance with all these standards will have a key impact on the health behavior of individual social groups. There have been demonstrably effective treatments that proved to be effective but were rapidly dismissed for unknown reasons, such as ivermectin and hydroxychloroquine. Various measures are used in the world to help inhibit its development. The properties of this element provide hope in preventing the development of the SARS-CoV-2 virus. The aim of this review is to synthesize the latest literature data and to present the effect of sodium selenite in reducing the incidence of COVID-19 disease.

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Section: Selenium As An Elementmentioning

confidence: 99%

Selenium in the Prevention of SARS-CoV-2 and Other Viruses

Kieliszek

2022

Biol Trace Elem Res

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“…[143][144][145] Recent transcriptional analysis of mRNAs, miRNAs and lncRNAs, combined with proteomic data from patients with KBD and Keshan disease, has revealed novel cellular pathways that may be related to selenium-related regulation of transcription. 146 A rat model of KBD was established by…”

Section: Ln Crna S and K A S Hin -B Eck D Is E A S E (Kbd)mentioning

confidence: 99%

LncRNAs as a new regulator of chronic musculoskeletal disorder

et al. 2021

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Musculoskeletal disorders are a group of conditions that affect the motor system, including bones, muscles, tendons, ligaments and joints. 1 People with multiple disorders are particularly vulnerable, especially in the context of an ageing population. Musculoskeletal disorders include a variety of conditions such as osteoarthritis (OA), rheumatoid arthritis (RA), osteopenia, osteoporosis, fractures, sarcopenia, etc. 2 Non-protein-coding RNA makes up 98% of the whole human genome. 3,4 These functional RNAs can be divided into two groups according to the threshold of 200 nucleotides (NTS): small and long non-coding RNAs (lncRNAs). 5,6 LncRNAs regulate the activities of both nearby and distant genes by multiple mechanisms. It could act as a scaffold for transcription factors and other molecules involved in transcription initiation. 7 Moreover, it could serve as protein and microRNA decoys to interfere with cell division by regulating a series of key genes. 8 For those mainly located in the cytoplasm, it could directly target mRNA and induce translation. 9 Currently, an increased number of lncRNAs are found to be involved in the regulation of development and homeostasis of skeletal muscle system. 10,11 It is notable that lncRNAs take key roles in musculoskeletal disorders.

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“…High-level expression of GPX4 can reduce the level of cell death by inhibiting ferroptosis. Selenocysteine peptide (Tat, SelPep) can also promote cell survival by inhibiting ferroptosis [ 62 ]. Auroral kinase A (AURKA) was significantly overexpressed in upper gastrointestinal adenocarcinoma (UGC), in which the methylation level of several CpG nucleotides upstream of miR-4715-3p increased.…”

Section: Mechanism Of Ferroptosismentioning

confidence: 99%

Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis Drive Emerging Nanotherapeutics in Tumor

Cheng

Xie

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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Currently, traditional cancer therapy still falls far short of expectations. However, a variety of invasive cancers that are resistant to chemotherapy (such as platinum drugs, one of the most applied antineoplastics in clinic) and targeted agents are susceptible to ferroptosis. Ferroptosis is a form of cell death that is driven by cell metabolism and iron-dependent lipid peroxidation. Ferroptosis inducers can eliminate the drug resistance of tumor cells in the mesenchymal state, effectively inhibit the drug resistance of acquired tumor cells, and optimize cancer efficacy. Research based on the epigenetic mechanism of ferroptosis is still in the stage of screening and verifying the regulatory effect, and there is no complete regulatory mechanism network. In this review, we expound on the epigenetic regulation and nonepigenetic mechanisms of ferroptosis and review the epigenetic-based mechanisms of tumor therapy potential and emerging nonepigenetic-based therapies (nanotherapeutics).

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Selenium-Related Transcriptional Regulation of Gene Expression

Cited by 16 publications

References 91 publications

Selenium in the Prevention of SARS-CoV-2 and Other Viruses

Selenium in the Prevention of SARS-CoV-2 and Other Viruses

LncRNAs as a new regulator of chronic musculoskeletal disorder

Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis Drive Emerging Nanotherapeutics in Tumor

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