Selenium-Related Transcriptional Regulation of Gene Expression

Qu, Chengjuan

doi:10.3390/ijms19092665

Cited by 39 publications

(17 citation statements)

References 125 publications

(151 reference statements)

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“…In relation to the above, Se contribution on metabolic pathways associated with the protection of the organism against oxidative stress was shown to induce changes in the activity of selenoproteins. Their expression is regulated, among others, by the concentration of this element [51]. However, Se concentration does not obligatorily affect the rate of transcription of selenoprotein genes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Selenium and Cadmium on Breast Muscle Fatty-Acid Composition and Gene Expression of Liver Antioxidant Proteins in Broilers

et al. 2019

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The present work was part of a project intended to evaluate whether organic selenium (Se) has the potential to protect against toxic effects exerted by cadmium (Cd). For this reason, 300 as-hatched, one-day-old broiler chickens were randomly allocated in four dietary treatments with five replicate pens per treatment. Chickens in T1 treatment, were offered a diet supplemented with 0.3 ppm Se (as Se-yeast), without added Cd; in T2 treatment, they were offered a diet with 0.3 ppm Se and 10 ppm Cd; in T3 treatment, they were offered a diet with 0.3 ppm Se and 100 ppm Cd; in T4 treatment, chickens were offered a diet supplemented with 3 ppm Se and 100 ppm Cd. Cadmium was added to the diets in T2, T3, and T4 as CdCl2. On the fourth and sixth weeks, liver and breast samples were obtained from two broilers per replicate pen. Relative gene expression levels of catalase (CAT), superoxide dismutase 1 (SOD1) and 2 (SOD2), methionine sulfoxide reductase A (MSRA) and B3 (MSRB3), iodothyronine deiodinase 1 (DIO1), 2 (DIO2), and 3 (DIO3), glutathione peroxidase 1 (GPX1) and 4 (GPX4), thioredoxin reductase 1 (TXNRD1) and 3 (TXNRD3), and metallothionein 3 (MT3) were analyzed by real-time quantitative PCR in liver, whereas the fatty-acid (FA) profile of breast muscle was determined by gas chromatography. Broilers supplemented with 0.3 ppm Se could tolerate low levels of Cd present in the diets, as there were no significant changes in the breast muscle FA profile, whereas excess Cd led to decreased polyunsaturated fatty acids (PUFAs), and in particular n-6 PUFA. Furthermore, treatments mainly affected the messenger RNA (mRNA) expression of SOD2, TXNRD3, and MT3, while age affected CAT, MSRB3, DIO2, DIO3, GPX4, TXNRD1, and MT3. In conclusion, dietary Se may help against the negative effects of Cd, but cannot be effective when Cd is present at excessive amounts in the diet.

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Section: Discussionmentioning

confidence: 99%

Effects of Selenium and Cadmium on Breast Muscle Fatty-Acid Composition and Gene Expression of Liver Antioxidant Proteins in Broilers

et al. 2019

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“…The share of selenium in the metabolic pathways associated with the protection of cells against oxidative stress causes changes in the activity of selenoproteins. Selenoprotein expression is regulated by the concentration of this element [57]. However, the selenium concentration does not affect the rate of transcription of selenoprotein genes.…”

Section: Effect Of Deficiency and Excess Of Selenium On Human Healthmentioning

confidence: 99%

Selenium–Fascinating Microelement, Properties and Sources in Food

2019

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Selenium is a micronutrient that is essential for the proper functioning of all organisms. Studies on the functions of selenium are rapidly developing. This element is a cofactor of many enzymes, for example, glutathione peroxidase or thioredoxin reductase. Insufficient supplementation of this element results in the increased risk of developing many chronic degenerative diseases. Selenium is important for the protection against oxidative stress, demonstrating the highest activity as a free radical scavenger and anti-cancer agent. In food, it is present in organic forms, as exemplified by selenomethionine and selenocysteine. In dietary supplementation, the inorganic forms of selenium (selenite and selenate) are used. Organic compounds are more easily absorbed by human organisms in comparison with inorganic compounds. Currently, selenium is considered an essential trace element of fundamental importance for human health. Extreme selenium deficiencies are widespread among people all over the world. Therefore, it is essential to supplement the deficiency of this micronutrient with selenium-enriched food or yeast cell biomass in the diet.

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“…In this special issue, a total of 19 excellent and interesting papers consisting of 11 original research studies, seven reviews, and one communication are published [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23]. They cover all subjects of transcriptional regulation, from cis-regulatory elements to transcription factors, chromatin regulators, and ncRNAs.…”

mentioning

confidence: 99%

“…Selenium-related transcriptional regulation is the topic of a comprehensive review [10]. Selenium is a trace element controlling the expression levels of numerous genes; it is essential to human health, and its deficiency is related to several diseases.…”

mentioning

confidence: 99%