Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters

Çelen, İlker Hüseyin; Müezzinoğlu, Talha; Ataman, O. Yavuz; Bakırdere, Sezgin; Korkmaz, Mehmet; Neşe, Nalan; Şenol, Feriye; Lekili, Murat

doi:10.1007/s11356-015-4555-y

Cited by 9 publications

(5 citation statements)

References 40 publications

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“…As we previously mentioned, not enough studies have examined the relationship between levels of Ni in the human body and their association with prostate cancer risk. The relationship between Ni, selenium, and calcium and prostate cancer was studied by Çelen et al [ 89 ]. They found a significantly lower Ni level in cancerous tissues than in benign prostate hyperplasia tissues.…”

Section: Discussionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.

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Section: Discussionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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“…In contrast, the Ni concentration in PCa tissue has been reported as being lower [ 18 ] or higher [ 19 , 20 ] compared to benign prostate tissue. The levels of Ni present in blood samples from patients with PCa have also been reported as higher compared to controls [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma Nickel Levels Correlate with Low Muscular Strength and Renal Function Parameters in Patients with Prostate Cancer

et al. 2022

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Nickel is associated with cancer in occupational exposure. However, few studies have been devoted to analyzing the effects of nickel at environmental concentrations in cancer patients. In this work, the concentration of nickel in blood samples from patients with prostate cancer (PCa) was evaluated because this metal displays androgenic and estrogenic effects that play a crucial role in prostate carcinogenesis and treatment. We, therefore, compared blood nickel concentration in patients with PCa (non-occupationally exposed) (n = 46) with those in control age-matched individuals (n = 46). We also analyzed if there was any association between sociodemographic factors, clinical variables, geriatric evaluation assessment results, blood cell counts, or biochemical, androgen and estrogen concentrations. Using inductively coupled plasma-mass spectroscopy on the plasma samples, we observed a mean nickel level of 4.97 ± 1.20 µg/L in the PCa group and 3.59 ± 0.49 µg/L in the control group, with a non-significant effect (p = 0.293) between the two groups. The nickel concentration was significantly correlated with patient age (p = 0.005) and reduced handgrip strength (p = 0.003). Regarding biochemical parameters, significant associations were found with the renal glomerular filtration rate (p = 0.024) and blood urea levels (p = 0.016). No significant correlations were observed with other blood analytical parameters or testosterone or estradiol levels. These specific renal function and muscle strength effects were observed at environmental nickel exposure levels believed to be safe or at least far from the high concentrations observed after occupational exposure. Therefore, these parameters deserve further study, given that they could help pinpoint further public health concerns regarding nickel exposure in the general population.

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“…The amount of selenium in prostate tissues was not significantly different ( p -value = 0.347) between cancer patients ( n = 49) and healthy controls ( n = 49), with mean concentrations of 191 and 168 µg/kg, respectively [ 103 ]. A comparison of prostate cancer cases ( n = 467) and controls ( n = 936) showed no statistical association between serum levels of selenium [ 104 ].…”

Section: Seleniummentioning

confidence: 99%

“…The tissue calcium levels were measured at 1431 mg/kg in healthy subjects ( n = 49) and 657 mg/kg in prostate cancer patients ( n = 50), with a statistically significant difference ( p -values < 0.001) [ 103 ]. Serum calcium levels were similar between ovarian cancer patients and healthy controls (9.34 and 9.31 mg/dL, respectively) but the normalization by serum albumin content was significantly higher in cases than in controls (9.95 mg/dL and 9.53 mg/dL, respectively; p -value < 0.01) [ 180 ].…”

Section: Calciummentioning

confidence: 99%

Minerals and Cancer: Overview of the Possible Diagnostic Value

Venturelli

Leischner

Helling

et al. 2022

Cancers

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Cancer is the second leading cause of death worldwide and is expected to increase by one-third over the next two decades, in parallel with the growing proportion of the elderly population. Treatment and control of cancer incidence is a global issue. Since there is no clear way to prevent or cure this deadly malignancy, diagnostic, predictive, and prognostic markers for oncological diseases are of great therapeutic value. Minerals and trace elements are important micronutrients for normal physiological function of the body. They are abundant in natural food sources and are regularly included in dietary supplements whereas highly processed industrial food often contains reduced or altered amounts of them. In modern society, the daily intake, storage pools, and homeostasis of these micronutrients are dependent on certain dietary habits and can be thrown out of balance by malignancies. The current work summarizes the data on minerals and trace elements associated with abnormal accumulation or depletion states in tumor patients and discusses their value as potential tumor-associated biomarkers that could be introduced into cancer therapy.

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Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters

Cited by 9 publications

References 40 publications

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Plasma Nickel Levels Correlate with Low Muscular Strength and Renal Function Parameters in Patients with Prostate Cancer

Minerals and Cancer: Overview of the Possible Diagnostic Value

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