Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and LncRNA-AF085935/GPC3 axis

AL-Noshokaty, Tohada M.; Mesbah, Noha M.; Abo-Elmatty, Dina M.; Abulsoud, Ahmed I.; Abdel-Hamed, Asmaa R.

doi:10.1016/j.lfs.2022.120675

Cited by 46 publications

(8 citation statements)

References 114 publications

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“…In addition, galactose-modified Se nanoparticles loaded with doxorubicin were developed to improve the antitumor efficacy of doxorubicin against HCC [ 184 ]. Se nanoparticles also had the ability to overcome sorafenib resistance in a rat HCC model by modulating apoptosis and mTOR/NF-κB signaling [ 185 ].…”

Section: Seleniummentioning

confidence: 99%

Current Trends on the Involvement of Zinc, Copper, and Selenium in the Process of Hepatocarcinogenesis

Himoto,

Masaki

2024

Nutrients

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Numerous nutritional factors increase the risk of hepatocellular carcinoma (HCC) development. The dysregulation of zinc, copper, and selenium homeostasis is associated with the occurrence of HCC. The impairment of the homeostasis of these essential trace elements results in oxidative stress, DNA damage, cell cycle progression, and angiogenesis, finally leading to hepatocarcinogenesis. These essential trace elements can affect the microenvironment in HCC. The carrier proteins for zinc and copper and selenium-containing enzymes play important roles in the prevention or progression of HCC. These trace elements enhance or alleviate the chemosensitivity of anticancer agents in patients with HCC. The zinc, copper, or selenium may affect the homeostasis of other trace elements with each other. Novel types of cell death including ferropotosis and cupropotosis are also associated with hepatocarcinogenesis. Therapeutic strategies for HCC that target these carrier proteins for zinc and copper or selenium-containing enzymes have been developed in in vitro and in vivo studies. The use of zinc-, copper- or selenium-nanoparticles has been considered as novel therapeutic agents for HCC. These results indicate that zinc, copper, and selenium may become promising therapeutic targets in patients with HCC. The clinical application of these agents is an urgent unmet requirement. This review article highlights the correlation between the dysregulation of the homeostasis of these essential trace elements and the development of HCC and summarizes the current trends on the roles of these essential trace elements in the pathogenesis of hepatocarcinogenesis.

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Section: Seleniummentioning

confidence: 99%

Current Trends on the Involvement of Zinc, Copper, and Selenium in the Process of Hepatocarcinogenesis

Himoto,

Masaki

2024

Nutrients

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“…Many epigenetic changes occur, including DNA methylation, histone modification, and miRNA channel silencing. ( Al-Noshokaty et al, 2022 ; Rizk et al, 2022 ). The complicated mechanism that governs gene expression relies on miRNAs by the utilization of miRNA sponges, miRNA-Masking Antisense Oligonucleotides, or antisense oligonucleotides that specifically target miRNAs (AMOs) ( Lima et al, 2018 ).…”

Section: Mirnas Biogenic Pathways and Functionmentioning

confidence: 99%

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Salama,

Eissa,

Doghish

et al. 2024

Front. Aging

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MicroRNAs (miRNAs) are short RNA molecules that are not involved in coding for proteins. They have a significant function in regulating gene expression after the process of transcription. Their participation in several biological processes has rendered them appealing subjects for investigating age-related disorders. Increasing data indicates that miRNAs can be influenced by dietary variables, such as macronutrients, micronutrients, trace minerals, and nutraceuticals. This review examines the influence of dietary factors and nutraceuticals on the regulation of miRNA in relation to the process of aging. We examine the present comprehension of miRNA disruption in age-related illnesses and emphasize the possibility of dietary manipulation as a means of prevention or treatment. Consolidating animal and human research is essential to validate the significance of dietary miRNA control in living organisms, despite the abundance of information already provided by several studies. This review elucidates the complex interaction among miRNAs, nutrition, and aging, offering valuable insights into promising areas for further research and potential therapies for age-related disorders.

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“…This process leads to an NP pro-oxidant behavior by free radical generation, on one side, which induces mitochondrial membrane disruption and, consequently, the leakage of mitochondrial proteins and endoplasmic reticulum (ER) stress on the other side [ 61 , 273 , 274 , 275 ]. Hence, several apoptotic molecular pathways which are regulated by SeNPs are activated or modulated, including TLR4/TRAF3/MFN1 (toll-like receptor-4/TNF receptor associated factor 3/mitofusin-1) [ 276 ]; p53, MAPK (mitogen-activated protein kinases) and AKT (protein kinase B) [ 277 , 278 , 279 ]; Bcl-2 family proteins [ 280 ]; ROS/JNK (c-Jun N-terminal kinase) [ 281 ]; PI3/Akt/mTOR (mammalian target of rapamycin); mTOR and NF-κB (nuclear factor kappa B) [ 282 ]; and caspase apoptotic pathways [ 268 , 280 , 283 ]. The regulation of these pathways is crucial for oncogenic signaling due to a considerable decrease in cellular proliferation and angiogenic signaling by obstructing the growth-promoting signaling in the vicinity of tumor cells.…”

Section: Properties Of Selenium Nanoparticlesmentioning

confidence: 99%

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

et al. 2023

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Selenium is an important dietary supplement and an essential trace element incorporated into selenoproteins with growth-modulating properties and cytotoxic mechanisms of action. However, different compounds of selenium usually possess a narrow nutritional or therapeutic window with a low degree of absorption and delicate safety margins, depending on the dose and the chemical form in which they are provided to the organism. Hence, selenium nanoparticles (SeNPs) are emerging as a novel therapeutic and diagnostic platform with decreased toxicity and the capacity to enhance the biological properties of Se-based compounds. Consistent with the exciting possibilities offered by nanotechnology in the diagnosis, treatment, and prevention of diseases, SeNPs are useful tools in current biomedical research with exceptional benefits as potential therapeutics, with enhanced bioavailability, improved targeting, and effectiveness against oxidative stress and inflammation-mediated disorders. In view of the need for developing eco-friendly, inexpensive, simple, and high-throughput biomedical agents that can also ally with theranostic purposes and exhibit negligible side effects, biogenic SeNPs are receiving special attention. The present manuscript aims to be a reference in its kind by providing the readership with a thorough and comprehensive review that emphasizes the current, yet expanding, possibilities offered by biogenic SeNPs in the biomedical field and the promise they hold among selenium-derived products to, eventually, elicit future developments. First, the present review recalls the physiological importance of selenium as an oligo-element and introduces the unique biological, physicochemical, optoelectronic, and catalytic properties of Se nanomaterials. Then, it addresses the significance of nanosizing on pharmacological activity (pharmacokinetics and pharmacodynamics) and cellular interactions of SeNPs. Importantly, it discusses in detail the role of biosynthesized SeNPs as innovative theranostic agents for personalized nanomedicine-based therapies. Finally, this review explores the role of biogenic SeNPs in the ongoing context of the SARS-CoV-2 pandemic and presents key prospects in translational nanomedicine.

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Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and LncRNA-AF085935/GPC3 axis

Cited by 46 publications

References 114 publications

Current Trends on the Involvement of Zinc, Copper, and Selenium in the Process of Hepatocarcinogenesis

Current Trends on the Involvement of Zinc, Copper, and Selenium in the Process of Hepatocarcinogenesis

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

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