Selenium nanoparticles as a nutritional supplement

Skaličková, Sylvie; Milosavljević, Vedran; Číhalová, Kristýna; Horký, Pavel; Richtera, Lukáš; Adam, Vojtěch

doi:10.1016/j.nut.2016.05.001

Cited by 359 publications

(211 citation statements)

References 99 publications

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“…Recently, nano-Se have received substantial attention as potential novel nutritional supplements because of their low toxicity and novel characteristics, such as great specific surface area, high surface activity, and high catalytic efficiency (Pelyhe and Mezes, 2013;Sarkar et al, 2015;Wadhwani et al, 2016;Skalickova et al, 2017). In addition, it has been suggested that nano-Se can have important applications in the field of medicine owing to their antibacterial and anticancer properties (Wang et al, 2007;Ahmed et al, 2014;Wadhwani et al, 2016).…”

Section: Selenium Nanoparticle (Nano-se) Productsmentioning

confidence: 99%

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

et al. 2018

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Selenium (Se) is an essential element in poultry nutrition and its bio-efficacy depends on its chemical form. A growing body of research proves that organic forms of Se, mainly selenomethionine (SeMet), in poultry diets have a range of important advantages over traditional sodium selenite. In fact, the organic Se concept considers SeMet as a storage form of Se in the chicken body. As chickens are not able to synthesize SeMet, its provision through diet is a key strategy to fight commercially relevant stresses. Indeed, in stress conditions, when increased selenoprotein expression requires additional Se, while its provision via feed usually decreases due to a reduction in feed consumption, Se reserves in the body (mainly in the muscles) could help maintain an effective antioxidant defense and prevent detrimental consequences of stresses. The poultry industry is looking for the most effective sources of organic Se for commercial use. In this review, advantages and disadvantages of main organic Se sources for poultry (Se-yeast, SeMet, and OH-SeMet) are analyzed, and future directions for the development of new Se sources are identified.

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Section: Selenium Nanoparticle (Nano-se) Productsmentioning

confidence: 99%

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

et al. 2018

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“…Selenium is an essential trace element with excellent antioxidant and chemopreventive activity and is the subject of numerous reviews [18][19][20][21]. Selenium nanoparticles (SeNPs) have emerged as potential drug carriers and has been used as an essential strategy in overcoming multi-drug resistance(MDR) through a combination of gene and drug therapeutics [22,23].…”

Section: Introductionmentioning

confidence: 99%

Polymerized Selenium Nanoparticles for Folate-Receptor-Targeted Delivery of Anti-Luc-siRNA: Potential for Gene Silencing

Maiyo

Singh

2020

Biomedicines

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The development of a biocompatible and nontoxic gene delivery vehicle remains a challenging task. Selenium nanoparticles (SeNPs) have the potential to increase delivery efficiency, to reduce side effects, and to improve therapeutic outcomes. In this study, chitosan (Ch) functionalized folate (FA)-targeted SeNPs were synthesized, characterized, and evaluated for their potential to bind, protect, and safely deliver Fluc-siRNA in vitro. SeNPs of less than 100 nm were successfully synthesised and further confirmed using UV-vis and Fourier transform infrared spectroscopy, transmission electron microscopy, and nanoparticle tracking analysis. Cell viability studies were conducted in vitro in selected cancer and non-cancer cell lines. Folate receptor (FOLR1) targeted and nontargeted luciferase gene silencing studies were assessed in the transformed Hela-tat-Luc cell line expressing the luciferase gene. Targeted and nontargeted SeNP nanocomplexes showed minimal toxicity in all cell lines at selected w/w ratios. Maximum gene silencing was achieved at optimum w/w ratios for both nanocomplexes, with Selenium-chitosan-folic acid (SeChFA) nanocomplexes showing slightly better transgene silencing, as supported by results from docking studies showing that SeChFA nanocomplexes interacted strongly with the folate receptor (FOLR1) with high binding energy of −4.4 kcal mol−1.

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“…Interaction between Se and Vitamin E may increase the production of glutathione peroxidase, which is an important part of the antioxidant system (Arruda et al 2015;Horky et al 2016b;Chen et al 2016a;Skalickova et al 2017;Tran & Webster 2011;Wang et al 2007;Zhang et al 2001). Moreover, selenium supports immune response, where it is in enzyme deiodinase necessary for conversion of tyroxine (T4) to more active triiodothyronine (T3) (Bunglavan et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, alternative nanotechnological solutions are searched instead of conventional alternatives as nanoparticles show new promising properties, which could supress toxicity with maintaining the positive effects of selenium on an organism (Arruda et al 2015;Fernandez-Llamosas et al 2016;Mohapatra et al 2014;Skalickova et al 2017). The synthesis and application of selenium nanoparticles (SeNPs) attracted increased attention due to several benefits, such as low toxicity, biocompatibility and chemical stability (Zhang et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

Urbánková

Horký

Skládanka

et al. 2018

Preprint

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Background. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles on antioxidant status of rats.Methods. The males of outbreed strain Wistar albino were selected as a model organism. Animals were fed with different forms of selenium. The control group was given mixture without selenium addition, whereas other groups were fed with mixture containing sodium selenite, Se-49 and Se-100 selenium nanoparticles, respectively. The duration of the trial was 30 days.Results. The analysis of blood and liver was performed where concentration of reduced (GSH) and oxidized (GSSG) glutathione, and the total selenium content were measured. In liver, a significant reduction in GSSG was found in all experimental groups. Blood samples showed a significant reduction in GSH and an increase in GSSG.Discussion. These results show that selenium nanoparticles may be an alternative to dietary selenium for the animal organism. AbstractBackground. The aim of the experiment was to determine the influence of sodium selenite and

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Selenium nanoparticles as a nutritional supplement

Cited by 359 publications

References 99 publications

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

Polymerized Selenium Nanoparticles for Folate-Receptor-Targeted Delivery of Anti-Luc-siRNA: Potential for Gene Silencing

Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

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