Selenium Modification of Natural Products and Its Research Progress

Abstract

The selenization of natural products refers to the chemical modification method of artificially introducing selenium atoms into natural products to interact with the functional groups in the target molecule to form selenides. Nowadays, even though scientists in fields involving organic selenium compounds have achieved numerous results due to their continuous investment, few comprehensive and systematic summaries relating to their research results can be found. The present paper summarizes the selenization modification methods of several kinds of important natural products, such as polysaccharides, proteins/polypeptides, polyphenols, lipids, and cyclic compounds, as well as the basic principles or mechanisms of the selenizing methods. On this basis, this paper explored the future development trend of the research field relating to selenized natural products, and it is hoped to provide some suggestions for directional selenization modification and the application of natural active ingredients.

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

“…Metabolically, selenium deficiency results in increased fat accumulation in the liver and intensified insulin resistance [ 69 ]. Research on soil selenium saturation indicates deficiencies in a significant percentage of the study material, corresponding to selenium deficiencies in food [ 70 , 71 ]. These deficiencies reflect low selenium saturation in living organisms and are associated with various health consequences, including an increased risk of cancer [ 72 ].…”