Selenium Levels in the Serum of Workers at a Rubber Tire Repair Shop

Sanchez-Ocampo, A.; Torres-Pérez, J.; Jiménez‐Reyes, M.

doi:10.1080/15428119691015250

Cited by 14 publications

(4 citation statements)

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“…Most processed selenium is used in the electronics industry, glass industry and as a component of pigments in plastics, paints, enamels, inks, and rubber101112. Moreover, selenium can be released into ambient air and soil when burning coal, fuel oil and waste or discharging sewage1314151617.…”

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confidence: 99%

Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: a cross-sectional analysis

Yang

Yan

Liu

et al. 2016

Sci Rep

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Selenium exposure can induce liver insulin resistance and increased liver triglyceride concentrations in animals, which may link to an increased risk of nonalcoholic fatty liver disease (NAFLD). However, epidemiological studies investigating the association between elevated plasma selenium levels and NAFLD were not available. We aimed to investigate the association of selenium levels with the prevalence of NAFLD in Chinese adults. This was a cross-sectional study of 8550 Chinese adults aged 40 yr or older in Shanghai, China. A questionnaire, anthropometric measurements, and laboratory tests were conducted. NAFLD was diagnosed by hepatic ultrasound after the exclusion of alcohol abuse and other liver diseases. Plasma selenium concentration was assessed by inductively coupled plasma mass spectroscopy. The median concentration of plasma selenium was 213.0 μg/L. Elevated plasma selenium levels were associated with higher triglycerides, LDL-cholesterol, fasting plasma glucose, post-loading plasma glucose, A1c, HOMA-IR, as well as ALT, AST and γ-GT (all P < 0.05). The odds ratios were substantially higher for NAFLD (OR = 1.54, 95% CI 1.13–2.18) in the highest selenium quartile compared with those in the lowest quartile, after adjustment for potential cofounder. The results of this study provided epidemiological evidence that increased plasma selenium level is associated with elevated prevalence of NAFLD.

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confidence: 99%

Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: a cross-sectional analysis

Yang

Yan

Liu

et al. 2016

Sci Rep

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“…However, selenium have been reported to be responsible for acute and chronic intoxication in cattle, horses, swine, chicken and other animals in regions with selenium-rich soil (Painter 1941;Moxon & Rhian 1943). Other toxic occupational exposures to selenium has also been observed (Srivastava et al 1995;Rajotte et al 1996;Sanchez-Ocampo et al 1996). Organs such as lungs, liver, spleen, kidneys and heart are targets for selenium toxicity (Tinsley et al 1967;Schwarz & Porter 1972;Oldfield 1987).…”

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confidence: 99%

Diphenyl Diselenide and Ascorbic Acid Changes Deposition of Selenium and Ascorbic Acid in Liver and Brain of Mice

Jacques-Silva

Nogueira

Broch

et al. 2001

Pharmacology & Toxicology

385

106

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Sodium selenite (Na 2 SeO 3 ) is the selenium form used in the composition of dietary supplements, and diphenyl diselenide (PhSe) 2 is an important intermediate in organic synthesis, which increases the risk of human exposure to this chemical in the workplace. These compounds have been reported to inhibit the cerebral and hepatic aminolevulinic acid dehydratase (ALA-D) in vitro, and now we show that ascorbic acid can reverse some alterations caused by in vivo selenium exposure, but not ALA-D inhibition. The effect of Na 2 SeO 3 or (PhSe) 2 and ascorbic acid on selenium distribution, total non-protein thiol, ascorbic acid content (liver and brain) and haemoglobin was also examined. Mice were exposed to 250 mmol/kg (PhSe) 2 , or 18.75 mmol/kg Na 2 SeO 3 subcutaneously, and to ascorbic acid, twice a day, 1 mmol/kg intraperitonially, for 10 days. Hepatic ALA-D of mice treated with (PhSe) 2 was inhibited about 58% and similar results were observed in the animals that received ascorbic acid supplementation (PϽ0.01, for (PhSe) 2 -treated and (PhSe) 2 πascorbic acid-treated mice). The haemoglobin content decreased after treatment with (PhSe) 2 (PϽ0.01). However, the haemoglobin content of the (PhSe) 2 πascorbic acid group was significantly higher than in the (PhSe) 2 -treated mice (PϽ0.05), and similar to control (PϾ0.10). Ascorbic acid treatment decreased significantly the hepatic and cerebral deposition of Se in (PhSe) 2 -exposed mice (PϽ0.01). Hepatic non-protein thiol content was not changed by treatment with (PhSe) 2 , ascorbic acid or (PhSe) 2 πascorbic acid. Hepatic content of ascorbic acid was twice that in mice that received (PhSe) 2 , independent of ascorbic acid treatment (PϽ0.001). The results of this study suggest that vitamin C may have a protective role in organodiselenide intoxication.

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“…High Se content in APM samples collected near VHS could be attributed to a high Se content in crude oil [30] and thus possibly also in products made from it-petrol and diesel fuels, asphalt, and tire rubber [21]. Selenium in tire production, besides its natural presence accompanying sulfur, can be added as a part of vulcanization additives [31]. Additionally, the high EF values for Br were not expected regarding the fact that leaded petrol containing brominated compounds as additives [18,19] has generally not been available in the Czech Republic since 2001.…”

Section: Analysis Of Averaged Enrichment Factorsmentioning

confidence: 99%

Neutron Activation Analysis in Urban Geochemistry: Impact of Traffic Intensification after Opening the Blanka Tunnel Complex in Prague

et al. 2022

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Opening of the Blanka Tunnel Complex (BTC) in Prague, Czech Republic, the longest city tunnel in Europe, significantly increased traffic on a connected main road, the V Holešovičkách street (VHS). To study environmental changes in VHS connected with BTC opening, sampling of road dust and airborne particulate matter in the VHS vicinity started 3 years before BTC opening and continued until BTC pilot operation. The enrichment factors calculated for the collected samples from elemental compositions determined by instrumental neutron activation analysis (INAA) have shown significant enrichment for Se, Sb, Hg, Br, Mo, Zn, As, W, Cr, Ba, and Fe, but not their increase after starting BTC operation. The Principal Component Analysis allowed distinguishing between detrital and anthropogenic, probably traffic related, origin of the elements determined in samples. The study demonstrated a potential of INAA for multielement trace analysis of minute samples (28 elements determined in samples down to 20 μg, with detection limits down to sub-ng level) and its application in urban geochemistry studies.

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Selenium Levels in the Serum of Workers at a Rubber Tire Repair Shop

Cited by 14 publications

References 0 publications

Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: a cross-sectional analysis

Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: a cross-sectional analysis

Diphenyl Diselenide and Ascorbic Acid Changes Deposition of Selenium and Ascorbic Acid in Liver and Brain of Mice

Neutron Activation Analysis in Urban Geochemistry: Impact of Traffic Intensification after Opening the Blanka Tunnel Complex in Prague

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