Selenium Levels in the Serum of Workers at a Rubber Tire Repair Shop

Sanchez-Ocampo, A.; Torres-Pérez, J.; Jiménez‐Reyes, M.

doi:10.1202/0002-8894(1996)057<0072:slitso>2.0.co;2

Cited by 2 publications

(2 citation statements)

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“…109,122 DMSe was detected in breath of a healthy male volunteer who had ingested a sub-toxic amount of selenium by cryotrapping-cryofocussing-GC-ICP-MS, 122 although the volatile selenocompounds in breath were not verified by molecular mass spectrometry. Garlicodor breath is one of the typical clinical symptoms of Se toxicosis by occupational exposure 123 and excess intake of nutritional Se supplements. 124 Since that odor can originate from volatile selenocompounds, this suggests indirectly that the volatile selenocompounds exist in breath.…”

Section: Excretion Of Sementioning

confidence: 99%

Selenometabolomics: Identification of selenometabolites and specification of their biological significance by complementary use of elemental and molecular mass spectrometry

Ogra

Anan

2009

J. Anal. At. Spectrom.

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Selenium (Se) shows ambivalent characteristics in animals and plants. It is an essential element in animals but becomes severely toxic when the amount ingested exceeds the required level. Meanwhile, Se is not essential in plants although some plants are Se hyperaccumulators. As Se changes into several chemical forms when metabolized, the identification of selenometabolites is considered to correspond to the depiction of the metabolic chart of Se. Hence, we are very much interested in unveiling selenometabolomes, i.e., the entirety of selenometabolites. Speciation with elemental and molecular mass spectrometry coupled with separation techniques has significantly contributed to the discovery of selenometabolomes. At the same time, speciation has highlighted some metabolites required for solid verification of the metabolic chart. The aim of this article is to review currently proposed Se metabolic pathways in animals and plants and to point out ambiguous selenometabolites from the viewpoint of speciation.

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Section: Excretion Of Sementioning

confidence: 99%

Selenometabolomics: Identification of selenometabolites and specification of their biological significance by complementary use of elemental and molecular mass spectrometry

Ogra

Anan

2009

J. Anal. At. Spectrom.

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“…However, selenium have been reported to be responsible for acute and chronic intoxication in cattle, horses, swine, chicken and other animals in regions with selenium-rich soil (Painter 1941;Moxon & Rhian 1943). Other toxic occupational exposures to selenium has also been observed (Srivastava et al 1995;Rajotte et al 1996;Sanchez-Ocampo et al 1996). Organs such as lungs, liver, spleen, kidneys and heart are targets for selenium toxicity (Tinsley et al 1967;Schwarz & Porter 1972;Oldfield 1987).…”

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confidence: 99%

Diphenyl Diselenide and Ascorbic Acid Changes Deposition of Selenium and Ascorbic Acid in Liver and Brain of Mice

Jacques-Silva

Nogueira

Broch

et al. 2001

Pharmacology & Toxicology

385

106

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Sodium selenite (Na 2 SeO 3 ) is the selenium form used in the composition of dietary supplements, and diphenyl diselenide (PhSe) 2 is an important intermediate in organic synthesis, which increases the risk of human exposure to this chemical in the workplace. These compounds have been reported to inhibit the cerebral and hepatic aminolevulinic acid dehydratase (ALA-D) in vitro, and now we show that ascorbic acid can reverse some alterations caused by in vivo selenium exposure, but not ALA-D inhibition. The effect of Na 2 SeO 3 or (PhSe) 2 and ascorbic acid on selenium distribution, total non-protein thiol, ascorbic acid content (liver and brain) and haemoglobin was also examined. Mice were exposed to 250 mmol/kg (PhSe) 2 , or 18.75 mmol/kg Na 2 SeO 3 subcutaneously, and to ascorbic acid, twice a day, 1 mmol/kg intraperitonially, for 10 days. Hepatic ALA-D of mice treated with (PhSe) 2 was inhibited about 58% and similar results were observed in the animals that received ascorbic acid supplementation (PϽ0.01, for (PhSe) 2 -treated and (PhSe) 2 πascorbic acid-treated mice). The haemoglobin content decreased after treatment with (PhSe) 2 (PϽ0.01). However, the haemoglobin content of the (PhSe) 2 πascorbic acid group was significantly higher than in the (PhSe) 2 -treated mice (PϽ0.05), and similar to control (PϾ0.10). Ascorbic acid treatment decreased significantly the hepatic and cerebral deposition of Se in (PhSe) 2 -exposed mice (PϽ0.01). Hepatic non-protein thiol content was not changed by treatment with (PhSe) 2 , ascorbic acid or (PhSe) 2 πascorbic acid. Hepatic content of ascorbic acid was twice that in mice that received (PhSe) 2 , independent of ascorbic acid treatment (PϽ0.001). The results of this study suggest that vitamin C may have a protective role in organodiselenide intoxication.

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Selenium Levels in the Serum of Workers at a Rubber Tire Repair Shop

Cited by 2 publications

References 0 publications

Selenometabolomics: Identification of selenometabolites and specification of their biological significance by complementary use of elemental and molecular mass spectrometry

Selenometabolomics: Identification of selenometabolites and specification of their biological significance by complementary use of elemental and molecular mass spectrometry

Diphenyl Diselenide and Ascorbic Acid Changes Deposition of Selenium and Ascorbic Acid in Liver and Brain of Mice

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