Selenium level in the environment and the population of Zhoukoudian area, Beijing, China

Li, Na; Gao, Zhijun; De-gang, Luo; Tang, Xun; Chen, Dafang; Hu, Yonghua

doi:10.1016/j.scitotenv.2007.03.027

Cited by 75 publications

(35 citation statements)

References 28 publications

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“…A second factor may be a relatively low Se intake. In the present study, the mean Se levels of normal volunteers and posttransplant patients with a CrCl≥50 ml/min varied around 66 μg/L which is similar to the values (75.0±28.4 μg/L) previously reported in the general population in the Zhoukoudian area of Beijing in China [24]. It is of note however, that the mean Se level in NRF subjects of the present study is lower than those reported in US residents (124.5± 0.20 μg/L in men, 122.0±0.20 μg/L in women) [25] and in the Chinese living in Singapore (126 μg/L in men, 119 μg/L in women) [26].…”

Section: Discussionsupporting

confidence: 90%

Selenium, Lead, and Cadmium Levels in Renal Failure Patients in China

Chen

Lamberts

Behets

et al. 2009

Biol Trace Elem Res

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Whole blood and serum samples of Chinese stable chronic renal failure (CRF) patients (n = 81), hemodialysis patients (n = 135), posttransplant patients (n = 60), and subjects with normal renal function (NRF; N = 42) were collected, as well as water and dialysate samples from five dialysis centers. The concentration of selenium (Se), lead (Pb), and cadmium (Cd) was measured by atomic absorption spectrometry. The mean serum Se levels in patients with different degrees of renal failure were significantly lower than those of subjects with NRF (p < 0.01). Pb levels were not increased in renal failure patients, while the Cd levels in patients with various degrees of renal failure were higher than in subjects with NRF (p < 0.05). After correcting the results of Pb and Cd for hematocrit (Hct) however, Pb levels of dialysis patients were also increased. In the dialysis population under study, blood Pb and Cd levels were closely related to the time on dialysis, while contamination of the final dialysate may also contribute to the increased blood Cd and to a less extent Pb levels. Correction for Hct may be recommended to accurately compare blood Pb and Cd levels in dialysis patients and CRF patients with varying degrees of anemia to those of subjects with NRF.

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Section: Discussionsupporting

confidence: 90%

Selenium, Lead, and Cadmium Levels in Renal Failure Patients in China

Chen

Lamberts

Behets

et al. 2009

Biol Trace Elem Res

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“…However, there were studies reporting non-significant association [19][20][21] while others supported an inverse association between selenium levels and hypertension [6,22,23]. In a cross-sectional study on 722 males with mean age 54 years old in eastern Finland higher selenium level was found to be associated with lower hypertension rate [6].…”

Section: Discussionmentioning

confidence: 99%

“…In a cross-sectional study on 722 males with mean age 54 years old in eastern Finland higher selenium level was found to be associated with lower hypertension rate [6]. Two case-control studies reported lower selenium in hypertensive patients than in normal controls [22,23]. In addition to observational studies, randomized controlled trials with selenium as one of the intervention agents also reported protective effect on hypertension [24,25].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Jin

Unverzagt

et al. 2016

The Journal of nutrition, health and aging

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Objectives:Results from previous studies have been inconsistent on the association between selenium and hypertension, and very few studies on this subject have focused on the elderly population. The purpose of this study is to examine the relationship between selenium level and hypertension in a rural elderly Chinese cohort.Design: A longitudinal study was implemented and data were analyzed using logistic regression models and Cox proportional hazards regression model adjusting for potential confounders. The association between selenium level and prevalent hypertension at baseline and between selenium and incident hypertension were examined. Setting:Community-based setting in four rural areas in China.Subjects: A total of 2000 elderly aged 65 years and over (mean 71.9±5.6 years) participated in this study.Measurements: Nail selenium levels were measured in all subjects at baseline. Blood pressure measures and self-reported hypertension history were collected at baseline, 2.5 years and 7 years later. Hypertension was defined as systolic blood pressure 140 mmHg or higher, diastolic blood pressure 90 mmHg or higher, or reported use of anti-hypertensive medication. Results:The rate of baseline hypertension was 63.50% in this cohort and the mean nail selenium level is 0.413±0.183μg/g. Multi-covariate adjusted cross-sectional analyses indicated that higher selenium level was associated with higher blood pressure measures at baseline and higher rates of hypertension. For the 635 participants with normal blood pressure at baseline, 360 had developed hypertension during follow-up. The incidence rate for hypertension was 45.83%, 52.27, 62.50%, 70.48%, and 62.79% from the first selenium quintile to the fifth quintile respectively. Comparing to the lowest quintile group, the hazard ratio were 1. for the second selenium quintile to the fifth quintile respectively. Conclusions:Our findings suggest that high selenium may play a harmful role in the development of hypertension. Future studies are needed to confirm our findings and to elucidate a plausible biological mechanism.

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“…The pathology results in enlarged joints, shortened fingers and toes, and dwarfism in extreme cases. 28,144 Keshan disease is a muscular disorder and is discussed in Section 5.2.…”

Section: Deficiency and Toxicitymentioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

635

451

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Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

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Selenium level in the environment and the population of Zhoukoudian area, Beijing, China

Cited by 75 publications

References 28 publications

Selenium, Lead, and Cadmium Levels in Renal Failure Patients in China

Selenium, Lead, and Cadmium Levels in Renal Failure Patients in China

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Selenium biochemistry and its role for human health

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