Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues

Kolivand, Sedighe; Amini, Peyman; Saffar, Hiva; Rezapoor, Saeed; Najafi, Masoud; Motevaseli, Elahe; Nouruzi, Farzad; Shabeeb, Dheyauldeen; Musa, Ahmed Eleojo

doi:10.15171/jcvtr.2019.21

Cited by 14 publications

(12 citation statements)

References 30 publications

(32 reference statements)

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“…Cardiovascular injury has been associated with radiation in cancer therapy (Eldabaje et al 2015 ), in which the redox modulation plays an important role. Therefore, selenomethionine (4 mg kg −1 ) was able to protect the rat heart tissue against radiation-induced injury by down-regulating the expression of dual oxidase (Duox1 and Duox2); two important pro-oxidant enzymes (Kolivand et al 2019 ).…”

Section: Pharmacology Of Organoselenium Compoundsmentioning

confidence: 99%

Toxicology and pharmacology of synthetic organoselenium compounds: an update

2021

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Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of selenium as a tool in organic synthesis and as a pharmacological agent goes back to the middle of the nineteenth and the beginning of the twentieth centuries. The rediscovery of ebselen and its investigation in clinical trials have motivated the search for new organoselenium molecules with pharmacological properties. Although ebselen and diselenides have some overlapping pharmacological properties, their molecular targets are not identical. However, they have similar anti-inflammatory and antioxidant activities, possibly, via activation of transcription factors, regulating the expression of antioxidant genes. In short, our knowledge about the pharmacological properties of simple organoselenium compounds is still elusive. However, contrary to our early expectations that they could imitate selenoproteins, organoselenium compounds seem to have non-specific modulatory activation of antioxidant pathways and specific inhibitory effects in some thiol-containing proteins. The thiol-oxidizing properties of organoselenium compounds are considered the molecular basis of their chronic toxicity; however, the acute use of organoselenium compounds as inhibitors of specific thiol-containing enzymes can be of therapeutic significance. In summary, the outcomes of the clinical trials of ebselen as a mimetic of lithium or as an inhibitor of SARS-CoV-2 proteases will be important to the field of organoselenium synthesis. The development of computational techniques that could predict rational modifications in the structure of organoselenium compounds to increase their specificity is required to construct a library of thiol-modifying agents with selectivity toward specific target proteins.

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Section: Pharmacology Of Organoselenium Compoundsmentioning

confidence: 99%

Toxicology and pharmacology of synthetic organoselenium compounds: an update

2021

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“…However, despite substantially reducing the dose of the accidental irradiation, radiation-induced cardiac events continue to occur. Furthermore, research is exploring protective agents which interfere with one or more of the identified pathophysiological mechanisms of radiation-induced CVD mainly through reducing chronic inflammation and oxidative stress [ 44 , 210 , 211 ]. In addition, non-traditional therapies against CVD are worth exploring…”

Section: Discussionmentioning

confidence: 99%

Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

et al. 2021

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Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly prominent among patients receiving mediastinal radiotherapy, such as breast cancer and Hodgkin's lymphoma patients. A number of mechanisms of radiation-induced CVD pathogenesis have been proposed such as endothelial inflammatory activation, premature endothelial senescence, increased ROS and mitochondrial dysfunction. However, current research seems to point to a so-far unexamined and potentially novel involvement of epigenetics in radiation-induced CVD pathogenesis. Firstly, epigenetic mechanisms have been implicated in CVD pathophysiology. In addition, several studies have shown that ionizing radiation can cause epigenetic modifications, especially DNA methylation alterations. As a result, this review aims to provide a summary of the current literature linking DNA methylation to radiation-induced CVD and thereby explore DNA methylation as a possible contributor to radiation-induced CVD pathogenesis.

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“…Myocarditis refers to as localized or diffuse inflammatory lesions of the myocardium, initiated by infectious factors, most commonly, viruses and non‐infectious factors, such as systemic autoimmune disease, medications and cardiotoxins 40 . It is believed that IL‐13 consecutively contributes to regulating recruitment and differentiation of immune cells, chemokines secretion and fibrosis during the progression of myocarditis 40‐42 . IL‐13 deficiency mice develop into severe myocarditis in both coxsackievirus B3 (CVB3)‐induced model and experimental autoimmune myocarditis (EAM) model, manifested in decreased systolic and diastolic left ventricular functions and decreased survival 41 .…”

Section: Role Of Il‐13 In Cvdsmentioning

confidence: 99%

Emerging role of interleukin‐13 in cardiovascular diseases: A ray of hope

Qian

Gao

Wang

et al. 2021

J Cellular Molecular Medi

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Despite the great progress made in the treatment for cardiovascular diseases (CVDs), the morbidity and mortality of CVDs remains high due to the lack of effective treatment strategy. Inflammation is a central pathophysiological feature of the heart in response to both acute and chronic injury, while the molecular basis and underlying mechanisms remains obscure. Interleukin (IL)‐13, a pro‐inflammatory cytokine, has been known as a critical mediator in allergy and asthma. Recent studies appraise the role of IL‐13 in CVDs, revealing that IL‐13 is not only involved in more obvious cardiac inflammatory diseases such as myocarditis but also relevant to acute or chronic CVDs of other origins, such as myocardial infarction and heart failure. The goal of this review is to summarize the advancement in our knowledge of the regulations and functions of IL‐13 in CVDs and to discuss the possible mechanisms of IL‐13 involved in CVDs. We highlight that IL‐13 may be a promising target for immunotherapy in CVDs.

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Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues

Cited by 14 publications

References 30 publications

Toxicology and pharmacology of synthetic organoselenium compounds: an update

Toxicology and pharmacology of synthetic organoselenium compounds: an update

Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

Emerging role of interleukin‐13 in cardiovascular diseases: A ray of hope

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