Selenium-induced antioxidant protection recruits modulation of thioredoxin reductase during excitotoxic/pro-oxidant events in the rat striatum

Maldonado, Perla D.; Cruz, Verónica Pérez-De La; Torres-Ramos, Mónica; Silva-Islas, Carlos Alfredo; Lecona-Vargas, Ramón; Lugo-Huitrón, Rafael; Ayala, Tonali Blanco; Ugalde‐Muñiz, Perla; Vázquez-Cervantes, Gustavo Ignacio; Fortoul, Teresa I.; Ali, Syed F.; Santamarı́a, Abel

doi:10.1016/j.neuint.2012.05.004

Cited by 17 publications

(11 citation statements)

References 53 publications

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“…It is normally presented in nanomolar concentrations in human brain and cerebrospinal fluid (CSF) and is often implicated in the pathogenesis of a variety of human neurological diseases [399]. QA has been used to induce lipid peroxidation mediated by hydroxyl radicals in vivo mammalian models [400–405]. …”

Section: The Use Of Mammalian Model In Lipid Peroxidation Researchmentioning

confidence: 99%

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Ayala

Muñoz

Argüelles

2014

Oxidative Medicine and Cellular Longevity

4,270

3,003

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Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs). Over the last four decades, an extensive body of literature regarding lipid peroxidation has shown its important role in cell biology and human health. Since the early 1970s, the total published research articles on the topic of lipid peroxidation was 98 (1970–1974) and has been increasing at almost 135-fold, by up to 13165 in last 4 years (2010–2013). New discoveries about the involvement in cellular physiology and pathology, as well as the control of lipid peroxidation, continue to emerge every day. Given the enormity of this field, this review focuses on biochemical concepts of lipid peroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summarizing not only its physiological and protective function as signaling molecule stimulating gene expression and cell survival, but also its cytotoxic role inhibiting gene expression and promoting cell death. Finally, overviews of in vivo mammalian model systems used to study the lipid peroxidation process, and common pathological processes linked to MDA and 4-HNE are shown.

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Section: The Use Of Mammalian Model In Lipid Peroxidation Researchmentioning

confidence: 99%

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Ayala

Muñoz

Argüelles

2014

Oxidative Medicine and Cellular Longevity

4,270

3,003

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“…Complex pathological situations such as infection by human immunodeficiency virus (Ellwanger et al 2011, Sudfeld et al 2014) and cancer (Yakubov et al 2014) also appear to be influenced by body levels of Se. In this context, the antioxidant function of Se (Maldonado et al 2012, Arigony et al 2013, Liu et al 2013 involves protecting from and slowing the development of diseases that involve oxidative damage to cellular components.…”

Section: Biological Roles Of Seleniummentioning

confidence: 99%

“…Little is known about the role of Se in pathologies that affect the central nervous system. However, Se has important antioxidant functions (Maldonado et al 2012, Liu et al 2013) and neuroprotective actions (Lu et al 2014, Naziroğlu et al 2014, Şenol et al 2014, Yang et al 2014. Therefore, Se in imbalance levels could be JOEL H. ELLWANGER, SILVIA I.R.…”

Section: Introductionmentioning

confidence: 99%

Biological functions of selenium and its potential influence on Parkinson's disease

Ellwanger

Franke

Bordin

et al. 2016

An. Acad. Bras. Ciênc.

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Parkinson's disease is characterized by the death of dopaminergic neurons, mainly in the substantia nigra, and causes serious locomotor dysfunctions. It is likely that the oxidative damage to cellular biomolecules is among the leading causes of neurodegeneration that occurs in the disease. Selenium is an essential mineral for proper functioning of the brain, and mainly due to its antioxidant activity, it is possible to exert a special role in the prevention and in the nutritional management of Parkinson's disease. Currently, few researchers have investigated the effects of selenium on Parkinson´s disease. However, it is known that very high or very low body levels of selenium can (possibly) contribute to the pathogenesis of Parkinson's disease, because this imbalance results in increased levels of oxidative stress. Therefore, the aim of this work is to review and discuss studies that have addressed these topics and to finally associate the information obtained from them so that these data and associations serve as input to new research.

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“…Western blot analysis was conducted following the reported methods [23][24][25]. Briefly, the renal tissue was homogenized in protein lysate buffer.…”

Section: Western Blotmentioning

confidence: 99%

GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats

Wu²,

Liu³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Diabetes mellitus (DM) can lead to renal damage and dysfunction, and exacerbate renal ischemia/reperfusion injury (RI/RI). The aim of this study was to investigate the protective effect of GSK-3β inhibitor TDZD-8 against RI/RI through Nrf2/TrxR2 signaling pathway in a rat DM model. Methods: A DM rat model was established by a single injection of streptozocin. Diabetic rats were pretreated with TDZD-8 (1 mg/kg bw) or TDZD-8+auranofin (10 nmol/L, 5ml/kg bw), and then subjected to 45-min ischemia and 24-h reperfusion. Rats were equally randomized into four groups: a Sham-operated group, a RI/RI group, a TDZD-8 group, and a TDZD-8+auranofin group. Serum levels of BUN and Scr were measured. SOD activity, MDA content, and Nrf2, TrxR2 and caspase-3 expressions in rat kidney tissues were determined. Results: Renal function was improved, oxidative stress and cell apoptosis were reduced, and the expression of Nrf2 and TrxR2 was up-regulated in TDZD-8 treated rats as compared with those in auranofin treated rats. Conclusion: TDZD-8 may exert its protective effect against RI/RI by regulating the Nrf2/TrxR2 signaling pathway in the kidney tissue in DM.

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Selenium-induced antioxidant protection recruits modulation of thioredoxin reductase during excitotoxic/pro-oxidant events in the rat striatum

Cited by 17 publications

References 53 publications

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Biological functions of selenium and its potential influence on Parkinson's disease

GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats

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