Selenium in the Immune System

Arthur, John R.; McKenzie, Roderick C.; Beckett, Geoffrey J.

doi:10.1093/jn/133.5.1457s

Cited by 457 publications

(275 citation statements)

References 21 publications

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“…One of the main functions of this element is as a component of the enzyme glutathione peroxidase, which, with vitamin E, protects against oxidation of cell membranes. Deficiency will result in degeneration of cardiac and skeletal muscle fibers, causing white muscle disease, immunosuppression (Arthur et al, 2003), and reduced reproductive success (Combs and Combs, 1986). In addition, Se deficiency has been shown to have a negative effect on preweaning fawn survival in wild black-tailed deer (Odocoileus hemionus columbianus; Flueck, 1994).…”

Section: Discussionmentioning

confidence: 99%

Hepatic Mineral Values of White-Tailed Deer (Odocoileus Virginianus) From Virginia

Sleeman

Magura

Howell

et al. 2010

Journal of Wildlife Diseases

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Section: Discussionmentioning

confidence: 99%

Hepatic Mineral Values of White-Tailed Deer (Odocoileus Virginianus) From Virginia

Sleeman

Magura

Howell

et al. 2010

Journal of Wildlife Diseases

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“…In addition to its antioxidant functions, Se is needed for a variety of other functions including neutrophil responses to pathogens [166], cell cycling [167], and metabolism of carcinogens [168].…”

Section: Seleniummentioning

confidence: 99%

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Cantin

White

Cross

et al. 2007

Free Radical Biology and Medicine

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Although great strides are being made in the care of individuals with cystic fibrosis (CF), this condition remains the most common fatal hereditary disease in North America. Numerous links exist between progression of CF lung disease and oxidative stress. The defect in CF is the loss of function of the transmembrane conductance regulator (CFTR) protein; recent evidence that CFTR expression and function are modulated by oxidative stress suggests that the loss may result in a poor adaptive response to oxidants. Pancreatic insufficiency in CF also increases susceptibility to deficiencies in lipophilic antioxidants. Finally the airway infection and inflammatory processes in the CF lung are potential sources of oxidants that can affect normal airway physiology and contribute to the mechanisms causing characteristic changes associated with bronchiectasis and loss of lung function. These multiple abnormalities in the oxidant/antioxidant balance raise several possibilities for therapeutic interventions that must be carefully assessed. IntroductionCystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America [1,2]. The defective gene was identified in 1989 [3][4][5] and shown to encode the cystic fibrosis trans-membrane conductance regulator protein (CFTR). CFTR is a cyclic AMP-regulated anion channel with greatest selectivity for chloride, and bicarbonate [6][7][8]. Furthermore, CFTR regulates sodium transport across epithelial membranes through interactions with the epithelial sodium channel ENaC [9], and facilitates the trans-membrane export of the small organic anionic peptide glutathione [10]. The expression of CFTR is located in the apical membrane of epithelial cells that line mucous membranes and submucosal glands ☆ A list of participants may be found in the Acknowledgments.

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“…These proteins include the antioxidant enzymes glutathione peroxidases (GSH-Px). As a consequence, Se plays a role in cell antioxidant defence, immune response and reduction of inflammation (Arthur et al, 2003;Schomburg et al, 2004). Feeding Se to pregnant or lactating females increases tissue Se content and GSH-Px activity in cows, ewes, sows and their offspring (Lacetera et al, 1996 andRock et al, 2001;Mahan and Peters, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of organic and inorganic selenium sources in sow diets on colostrum production and piglet response to a poor sanitary environment after weaning

Quesnel

Renaudin

Floc'H

et al. 2008

Animal

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The objectives of this study were to determine the effect of the chemical form of selenium (Se) fed to sows (1) on production and immune quality of colostrum and (2) on piglet response to a deterioration of sanitary conditions after weaning. Twenty-two pregnant sows were assigned to receive a diet supplemented with 0.3 ppm Se from either sodium selenite (inorganic Se) or Se-enriched yeast (organic Se as Sel-Plex R ; Alltech Inc., Nicholasville, KY, USA). Dietary treatments were applied during the last month of pregnancy and lactation. Blood samples were collected on sows before dietary treatment, on the day of weaning and 6 weeks later, and on three to five piglets within litters at birth, at weaning and 6 weeks post weaning. Whole blood was analysed for Se concentration. Colostrum samples were collected at 0, 3, 6 and 24 h post partum and milk samples on days 14 and 27 of lactation. Colostrum and milk were analysed for Se and immunoglobulin G (IgG) concentrations. At weaning, 40 pairs of littermate piglets were moved to rooms where sanitary conditions were good or purposely deteriorated. Piglets were reared individually and fed ad libitum. After 15 days, piglets and feed refusals were weighed and a blood sample was collected to measure plasma haptoglobin concentration. When sows were fed organic Se, Se concentrations were increased by 33% in colostrum (P , 0.05), 89% in milk (P , 0.001) and by 28% in whole blood of piglets at weaning (P , 0.001). Colostrum production during the 24 h after the onset of farrowing and IgG concentrations in colostrum and milk did not significantly differ between the two groups of sows. Weaned piglets reared in good sanitary conditions grew faster (P , 0.001) than piglets housed in poor conditions. Sanitary conditions did not influence mean plasma haptoglobin concentrations of piglets (P . 0.1). The source of Se fed to the dams did not influence piglet performance or haptoglobin concentrations after weaning. These findings confirm that, compared with inorganic Se, organic Se fed to the dam is better transferred to colostrum and milk, and consequently to piglets. They indicate that the Se source influences neither colostrum production nor IgG concentrations in colostrum, and that the higher Se contents of piglets does not limit the reduction of growth performance when weaning occurs in experimentally deteriorated sanitary conditions.

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Selenium in the Immune System

Cited by 457 publications

References 21 publications

Hepatic Mineral Values of White-Tailed Deer (Odocoileus Virginianus) From Virginia

Hepatic Mineral Values of White-Tailed Deer (Odocoileus Virginianus) From Virginia

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Effect of organic and inorganic selenium sources in sow diets on colostrum production and piglet response to a poor sanitary environment after weaning

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