Selenium in HIV/AIDS

Campa, Adriana; Martínez, Sabrina Sales; Baum, Marianna K.

doi:10.1007/978-3-319-41283-2_28

Cited by 3 publications

(3 citation statements)

References 87 publications

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“…Selenium is implicated in the inhibition of viral expression, and in the delay of the progression of AIDS in HIV-positive patients [ 203 , 204 ]. HIV/AIDS is a major health priority worldwide and the development of efficient antiretroviral therapy increased the number of people living with HIV.…”

Section: Hivmentioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

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Selenium is an essential microelement required for a number of biological functions. Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 human selenoproteins involved in a wide variety of essential biological functions, ranging from the regulation of reactive oxygen species (ROS) concentration to the biosynthesis of hormones. These processes also play a central role in preventing and modulating the clinical outcome of several diseases, including cancer, diabetes, Alzheimer’s disease, mental disorders, cardiovascular disorders, fertility impairments, inflammation, and infections (including SARS-CoV-2). Over the past years, a number of studies focusing on the relationship between selenium and such pathologies have been reported. Generally, an adequate selenium nutritional state—and in some cases selenium supplementation—have been related to improved prognostic outcome and reduced risk of developing several diseases. On the other hand, supra-nutritional levels might have adverse effects. The results of recent studies focusing on these topics are summarized and discussed in this review, with particular emphasis on advances achieved in the last decade.

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Section: Hivmentioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

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“…Selenium is an essential trace element implicated in many facets of human health and disease. This element is often evoked in the context of immune function and infectious diseases caused by viruses or bacteria [5,12]. The current example of the COVID-19 pandemic, due to the SARS-CoV-2 viral infection, confirms this finding with an association between low levels of selenium in body fluids and poor prognosis of infected patients hospitalized in intensive care units, as reviewed in [13].…”

Section: Introductionmentioning

confidence: 75%

Interplay between Selenium, Selenoproteins and HIV-1 Replication in Human CD4 T-Lymphocytes

Guillin

Vindry

Ohlmann

et al. 2022

IJMS

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The infection of CD4 T-lymphocytes with human immunodeficiency virus (HIV), the etiological agent of acquired immunodeficiency syndrome (AIDS), disrupts cellular homeostasis, increases oxidative stress and interferes with micronutrient metabolism. Viral replication simultaneously increases the demand for micronutrients and causes their loss, as for selenium (Se). In HIV-infected patients, selenium deficiency was associated with a lower CD4 T-cell count and a shorter life expectancy. Selenium has an important role in antioxidant defense, redox signaling and redox homeostasis, and most of these biological activities are mediated by its incorporation in an essential family of redox enzymes, namely the selenoproteins. Here, we have investigated how selenium and selenoproteins interplay with HIV infection in different cellular models of human CD4 T lymphocytes derived from established cell lines (Jurkat and SupT1) and isolated primary CD4 T cells. First, we characterized the expression of the selenoproteome in various human T-cell models and found it tightly regulated by the selenium level of the culture media, which was in agreement with reports from non-immune cells. Then, we showed that selenium had no significant effect on HIV-1 protein production nor on infectivity, but slightly reduced the percentage of infected cells in a Jurkat cell line and isolated primary CD4 T cells. Finally, in response to HIV-1 infection, the selenoproteome was slightly altered.

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“…Inadequate levels of selenium are associated with gastroenteritis and dermatitis, impaired thyroid hormone metabolism [270], cancers [271], male subfertility, liver dysfunctions [272], weakened immune functions [273], liver dysfunctions, mood disorders, and progression of HIV-1 infection and mortality [38,121,122,274]. With lower levels of selenium, PLWH have higher levels of oxidative stress, increased opportunistic infections, increased viral load, and higher mortality rates [122, [274][275][276].…”

Section: Selenium (Se 2+ )mentioning

confidence: 99%

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

Khan

Chen

Geiger

2020

Viruses

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Divalent cations are essential for life and are fundamentally important coordinators of cellular metabolism, cell growth, host-pathogen interactions, and cell death. Specifically, for human immunodeficiency virus type-1 (HIV-1), divalent cations are required for interactions between viral and host factors that govern HIV-1 replication and pathogenicity. Homeostatic regulation of divalent cations’ levels and actions appear to change as HIV-1 infection progresses and as changes occur between HIV-1 and the host. In people living with HIV-1, dietary supplementation with divalent cations may increase HIV-1 replication, whereas cation chelation may suppress HIV-1 replication and decrease disease progression. Here, we review literature on the roles of zinc (Zn2+), iron (Fe2+), manganese (Mn2+), magnesium (Mg2+), selenium (Se2+), and copper (Cu2+) in HIV-1 replication and pathogenicity, as well as evidence that divalent cation levels and actions may be targeted therapeutically in people living with HIV-1.

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Selenium in HIV/AIDS

Cited by 3 publications

References 87 publications

The Role of Selenium in Pathologies: An Updated Review

The Role of Selenium in Pathologies: An Updated Review

Interplay between Selenium, Selenoproteins and HIV-1 Replication in Human CD4 T-Lymphocytes

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

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