Selenium in blood and human tissues

Dickson, Robert C.; Tomlinson, R. H.

doi:10.1016/0009-8981(67)90197-0

Cited by 220 publications

(47 citation statements)

References 7 publications

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“…This finding was very likely related to different dietary and lifestyle habits influencing Se intake in the two populations. Age and sex did not show any rele vant influence on the Se status in both groups, as reported [29,30],…”

Section: Discussionsupporting

confidence: 54%

Geographic Factors and Plasma Selenium in Uremia and Dialysis

Bonomini

Förster

Manfrini

et al. 1996

Nephron

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The importance of selenium (Se) as an essential trace element for man has been increasingly recognized. Blood Se levels in chronic uremic patients are frequently reported to be lower than in controls. Definitive determination of the Se status in uremic patients, however, is hampered by the wide range of blood Se content in humans from different parts of the world. The present study was designed to assess and compare the Se status in two European populations from Rostock (Germany) and Chieti (Italy). Plasma Se levels were evaluated in healthy controls, chronic renal failure nondialyzed patients (CRF) and hemodialysis patients (HD). All Se determinations were performed in a single laboratory. The Se concentration was significantly higher (p < 0.005) in Italian healthy controls than in German healthy controls. In contrast, Se levels were similar in both CRF and HD patients from both cities. In both countries, the Se concentration in CRF and HD patients was significantly lower (p < 0.001) than in their corresponding controls, but no difference between CRF and HD was found. CRF and HD patients from the two countries showed quite similar laboratory and anthropometric data. In CRF patients in Chieti, a significant (p < 0.05) negative correlation between plasma Se and serum creatinine was found. In both HD groups, the length of time on HD and type of membrane dialyzer used did not influence the Se status. A significant positive correlation (p < 0.01) between Se levels and the protein catabolic rate was found in both HD groups. Uremia seems to be a strong factor which overrules the difference in Se levels that is present in healthy adults from different European countries. Uremia in itself may influence and level the Se concentration in patients with geographic diversity.

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Section: Discussionsupporting

confidence: 54%

Geographic Factors and Plasma Selenium in Uremia and Dialysis

Bonomini

Förster

Manfrini

et al. 1996

Nephron

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“…On the other hand, abnormally low serum and whole-blood Se levels in patients with chronic renal fail ure have been reported by Cornells et al [6] and Brunett al. [4], Selenium determination in serum is considered a bet ter indicator than selenium determination in plasma or whole blood [19,20]. Serum Se is remarkably stable over long periods of time, provided that no major changes in life style occur.…”

Section: Discussionmentioning

confidence: 99%

Selenium and Haemodialysis: Serum Selenium Levels in Healthy Persons, Non-Cancer and Cancer Patients with Chronic Renal Failure

Kallistratos

Evangelou

Seferiadis

et al. 1985

Nephron

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In 40 healthy persons, 11 nondialyzed uremic patients and 27 dialyzed uremic patients, of whom 4 also had cancer, the selenium concentration in serum was determined. The mean serum selenium concentration in healthy persons was 13.6 ± 0.8 μg/dl, in nondialyzed patients 11.9 ± 1.9 μg/dl and in dialyzed uremic patients 11.3 ± 1.0 μg/dl. There was a significant statistical difference between healthy persons and uremic patients (p < 0.00l), but not between dialyzed and nondialyzed uremic patients. The subgroup of cancer patients on hemodialysis also had low serum selenium concentrations. The possible role of low selenium levels as one of the factors responsible for the increased incidence of malignancy in patients with chronic renal failure is supported by several facts such as: (a) low serum selenium levels detected in patients with malignant diseases; (b) the higher cancer incidence in inhabitants of low-selenium areas, and (c) the known ability of selenium to inhibit many types of experimental carcinogenesis.

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“…Selenium deficiency will cause skeletal and cardiac muscle dysfunction [6,7] and the element is known to prevent cell membranes from oxidative damage [8,9 ]. The early literature contains claims that selenite and selenate may have mutagenic effects [10,11].…”

Section: Introductionmentioning

confidence: 99%