Selenium, glutathione peroxidases, and some other antioxidant parameters in blood of patients with chronic renal failure

Zachara, B; Trafikowska, U.; Adamowicz, Andrzej; Nartowicz, E; Manitius, Jacek

doi:10.1016/s0946-672x(01)80061-4

Cited by 37 publications

(32 citation statements)

References 40 publications

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“…We have found increased SOD activity and decreased G-Px activity in patients as compared to controls. In agreement with our data, Zachara et al [24] determined 53% lower plasma G-Px activity in CKD patients as compared to controls. Previously, Yoshimura et al [25] had reported that G-Px activity in nondialyzed patients with CKD is negatively correlated with serum creatinine level, and the plasma GPx activity largely depends on renal function.…”

Section: Discussionsupporting

confidence: 93%

Assessment of DNA Oxidation and Antioxidant Activity in Hypertensive Patients with Chronic Kidney Disease

et al. 2008

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The aim of this study was to evaluate the oxidative DNA damage, antioxidant activity, and effects of antihypertensive drugs on oxidative stress in hypertensive patients with different stages of chronic kidney disease (CKD). Fifty-three non-dialyzed hypertensive CKD patients were included by the study. Serum and urinary 8-hydroxydeoxy guanosine (8-OHdG) levels (as a marker of oxidative DNA damage), serum superoxide dismutase (SOD), and glutathione peroxidase (G-Px) activities (as antioxidant enzymes) were measured. SOD activity was higher and G-Px activity was lower in the patient group as compared to control group. Serum and urinary 8-OHdG levels were found to be higher in the patients with proteinuria greater than 3 g/day than those in the patients with proteinuria less than 3 g/day. It has been determined that G-Px activity and urinary 8-OHdG level were lower in the patients treated with angiotensinconverting enzyme (ACE) inhibitor compared to patients treated with calcium channel blocker. The present data show oxidative DNA damage at a higher level in the patients with proteinuria greater than 3 g/day. In comparison to a calcium channel blocker, an ACE inhibitor seems much more protective against oxidative DNA damage in hypertensive patients with different stages of CKD.

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Section: Discussionsupporting

confidence: 93%

Assessment of DNA Oxidation and Antioxidant Activity in Hypertensive Patients with Chronic Kidney Disease

et al. 2008

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“…Our findings also could reflect differences in response to oxidative stress in cats as a species compared to humans. For example, humans with advanced CKD show lower plasma activities of glutathione peroxidase (GPx), lower concentrations of its cofactor selenium, and lower reduced‐to‐oxidized glutathione (GSH:GSSG) ratios 6, 8, 35, 36. In contrast, cats with stage 4 CKD show a modest but significant increase in plasma GPx activities, with no decreases in serum selenium concentrations, and higher GSH:GSSG ratios 26, 37.…”

Section: Discussionmentioning

confidence: 99%

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Whitehouse

Quimby

Wan

et al. 2017

Veterinary Internal Medicne

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BackgroundF2‐isoprostanes, a biomarker of oxidant injury, increase with advancing chronic kidney disease (CKD) in humans. In cats, the relationship between CKD and oxidative stress is poorly understood.ObjectivesTo determine whether cats with advancing CKD have increasing urinary F2‐isoprostanes.AnimalsControl cats without evidence of CKD (≥6 years old; n = 11), and cats with IRIS stage 1 (n = 8), 2 (n = 38), 3 (n = 21), and 4 (n = 10) CKD.MethodsThis was a prospective observational study. Urinary F2‐isoprostanes (specifically free 15‐F2t‐isoprostanes) normalized to urine creatinine (IsoPs) were compared among groups and tested for correlations with blood pressure, proteinuria, serum creatinine concentration, and urine specific gravity. The IsoPs also were compared between cats with and without hypertension or proteinuria, and in cats fed predominantly standard versus renal diets.ResultsUrinary IsoPs were increased, but not significantly, in cats with stage 1 CKD (median 263 pg/mg creatinine; range, 211–380) compared to controls (182 pg/mg; range, 80–348) and decreased significantly from stage 1 through advancing CKD (stage 2, 144 pg/mg; range, 49–608; stage 3, 102 pg/mg; range, 25–158; stage 4, 67 pg/mg; range, 26–117; P < .01). Urinary IsoPs were inversely correlated with serum creatinine (r = −0.66, P < .0001).Conclusion and Clinical ImportanceUrinary IsoPs are significantly higher in early CKD (stage 1) compared to cats with more advanced CKD. Additional studies are warranted to characterize oxidative stress in cats with stage 1 CKD and determine whether early antioxidant treatments have a protective effect on CKD progression.

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“…[171][172][173] Decreased dietary intake of Se, increased urinary (or dialytic) loss, impaired intestinal absorption, abnormal binding to Se transport proteins and other mechanisms have been proposed to explain this association, but conclusive results are still missing. Since the circulating levels of Se are low in CRF and HD patients, Se supplementation could lead to positive effects, as recently demonstrated for immune function improvement and oxidative stress reduction, 174 at least in some cases, but may be insufficient in others.…”

Section: Renal Failurementioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

629

451

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Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

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Selenium, glutathione peroxidases, and some other antioxidant parameters in blood of patients with chronic renal failure

Cited by 37 publications

References 40 publications

Assessment of DNA Oxidation and Antioxidant Activity in Hypertensive Patients with Chronic Kidney Disease

Assessment of DNA Oxidation and Antioxidant Activity in Hypertensive Patients with Chronic Kidney Disease

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Selenium biochemistry and its role for human health

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Selenium, glutathione peroxidases, and some other antioxidant parameters in blood of patients with chronic renal failure

Cited by 37 publications

References 40 publications

Assessment of DNA Oxidation and Antioxidant Activity in Hypertensive Patients with Chronic Kidney Disease

Assessment of DNA Oxidation and Antioxidant Activity in Hypertensive Patients with Chronic Kidney Disease

Urinary F2‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Selenium biochemistry and its role for human health

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Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease