Selenium-enriched yeast reduces caecal pathological injuries and intervenes changes of the diversity of caecal microbiota caused by Ochratoxin-A in broilers

Yang, Shuai; Li, Lin; Yu, Li-Hui; Sun, Lin; Li, Kang; Cui, Tong; Xu, Weixiang; Cui, Gengyuan; Long, Miao; Li, Peng

doi:10.1016/j.fct.2020.111139

Cited by 44 publications

(28 citation statements)

References 41 publications

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“…Furthermore, PICRUSt analysis demonstrated that the altered microbiota was enriched in energy metabolism (nitrogen metabolism) and translation proteins with selenium yeast supplementation. Selenium yeast can interfere with the diversity of gut microbiota and reduce the abundance of harmful bacteria caused by Ochratoxin-A [28]. The increase in the abundance of Veillonella may produce more propionate and maintain energy homeostasis [68][69][70].…”

Section: Discussionmentioning

confidence: 99%

“…Generally, selenium yeast is a high-quality organic Se source for animals which is incorporated into proteins structures to improve bioavailability compared with inorganic sources, such as sodium selenite [28]. Differences in the sources of Se may have diverse effects on gene expression of hosts.…”

Section: Transcriptome Analysis Revealed Selenium Yeast Supplementatimentioning

confidence: 99%

“…Organic forms of Se, such as selenium yeast, are considered more e cient than inorganic forms [27]. Since Selenium yeast could intervene changes in the diversity of gut microbiota caused by ochratoxin-A [28]. The links between changes in gut microbiota and selenoprotein gene expression after dietary Se supplementation has been illustrated in early ndings, dietary Se can alter the composition of the gut microbiota, while also in uencing both the host Se state and selenoprotein expression [3,24,26].…”

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confidence: 99%

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Selenium yeast modulated ileal transcriptome and microbiota to ameliorate egg production in aged laying hens

Liu

Cao

et al. 2020

Preprint

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Background: The declines in both laying performance and egg shell quality during late production period have adverse effects on long production cycle. Improving nutrition of laying hens is a crucial measure to reverse the declination. Selenium (Se) plays important roles in antioxidant defense, redox balance, immune response, and modulation of gut microbiota. However, the mechanism underlying selenium yeast regulating the interaction between transcriptome and gut microbiota to influence laying performance, is still unclear. Here, we use the transcriptome and 16S rRNA analysis to investigate how selenium yeast alters the gene expression and microbiota composition of ileum in aged laying hens.Results: In this study, selenium yeast ameliorated the depression in aged laying performance with a significant increase of laying rate in 0.30 mg/kg group. Furthermore, functional enrichment and STEM analysis were performed using RNA-Seq, which indicated selenium yeast activated metabolic progresses (e.g. Glycerolipid metabolism, Glycerophospholipid metabolism, and fatty acid metabolism), immune response and oxidative stress response. Four hub genes (TXNRD1, DLD, ILK and LZTS2) were involved in intestinal metabolism which was closely associated with Se deposition/status. Additionally, Se increased the abundance of beneficial bacteria including Veillonella, Turicibacter, and Lactobacillus whiledecreasing the abundance of pathogenic bacteria Stenotrophomonas by 16S rRNA-Seq. The Integrated analysis of omics revealed that several microbiotas (Maritalea, Alteromonas, Geobacter, etc.) were positively associated with both Se content and laying rate, and there was a markable correlation between several specific microbiotas (Aliivibrio, Anaerobacillus, Shewanella, etc.) and the immune response pathways (regulation of acute inflammatory response, positive regulation of lymphocyte activation and IFN gamma response). Meanwhile, the “switched on” gene PSCA had a positive relationship with Veillonella, and a negative relationship with the opportunistic pathogens Stenotrophomonas. CCA analysis indicated that both the Se content and the laying rate were highly positively correlated with Anaerobacillus, Alteromonas, Loktanella and the positive regulation of lymphocyte activation, but were negative correlated with Streptococcus, Devosia, Aerococcus, Intestinibacter and fatty acid metabolic progress. Conclusions: Overall, our study provides unprecedented insights showing that selenium yeast supplementation can affect immune response, metabolic processes, and specific microbiota composition to ameliorate the egg production deterioration in aged laying hens.

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Section: Discussionmentioning

confidence: 99%

Section: Transcriptome Analysis Revealed Selenium Yeast Supplementatimentioning

confidence: 99%

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confidence: 99%

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Selenium yeast modulated ileal transcriptome and microbiota to ameliorate egg production in aged laying hens

Liu

Cao

et al. 2020

Preprint

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“…This mycotoxin is quickly absorbed by the small intestine in birds [15,16]. OTA affects the gastrointestinal tract (GIT) through inflammatory response/oxidative stress and by decreasing villus height [7,17]. The villus height is important for increasing the intestinal absorption surface and represents an important factor in determining animal performance [18].…”

Section: Introductionmentioning

confidence: 99%

“…The GIT also presents an important protective function against the invasion of microorganisms [18]; however, in this context, there are few studies on the effects of OTA in poultry intestinal mucosa. Increased inflammatory cytokines and decreased anti-inflammatory cytokines due to OTA have been observed in cecal tissues of broiler chickens [17]. Solcan et al [19] showed a significant reduction in the two main lymphocyte subpopulations, CD4 + and CD8 + , which are cells that are important for the cellular immune response in the intestinal tissues in chickens, depending on OTA dose and exposure time.…”

Section: Introductionmentioning

confidence: 99%

Tryptophan Attenuates the Effects of OTA on Intestinal Morphology and Local IgA/IgY Production in Broiler Chicks

Ricci

Terkelli

Venâncio

et al. 2020

Toxins

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Ochratoxin A (OTA) is a mycotoxin produced by species of Penicillium and Aspergillus that can contaminate products of plant origin that are used as animal feed. Through oral exposure, this mycotoxin primarily affects the chicken gastrointestinal system. The present study evaluated the intestinal toxic effects of OTA and the introduction of L-tryptophan to alleviate these effects in chickens. One-day-old chicks were exposed to a single OTA dose (1.4 mg/kg body weight—b.w.) and treated with or without four daily doses of L-tryptophan (100 mg/kg b.w.). Duodenal villus height/crypt depth, fecal immunoglobulin A/immunoglobulin Y (IgA/IgY) levels, and duodenal positive immunoglobulin A cells (IgA+) were evaluated by histology, ELISA, and immunohistochemistry, respectively, on the 14th day. There were significant changes in the duodenal villus height, crypt depth, and levels of fecal IgA/IgY and duodenal IgA+ cells (p < 0.05) in groups exposed to OTA. On the other hand, groups exposed to OTA and treated with L-tryptophan showed similar levels of villus height, IgA/IgY levels, and duodenal IgA+ cells to those of the control group (p > 0.05). In conclusion, exposure to a single dose of OTA orally induces changes in intestinal morphology, levels of IgA/IgY antibodies, and IgA+ cells. Thus, treatment with L-tryptophan may be a valid alternative means to reduce the harmful effects of OTA on the intestinal mucosa, which requires further study.

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Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury

et al. 2022

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Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen-and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies.

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Selenium-enriched yeast reduces caecal pathological injuries and intervenes changes of the diversity of caecal microbiota caused by Ochratoxin-A in broilers

Cited by 44 publications

References 41 publications

Selenium yeast modulated ileal transcriptome and microbiota to ameliorate egg production in aged laying hens

Selenium yeast modulated ileal transcriptome and microbiota to ameliorate egg production in aged laying hens

Tryptophan Attenuates the Effects of OTA on Intestinal Morphology and Local IgA/IgY Production in Broiler Chicks

Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury

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