Selenium-enriched yeast modulates the metal bioaccumulation, oxidant status, and inflammation in copper-stressed broiler chickens

Abstract

Copper (Cu) could be seriously hazardous when present at excessive levels, despite its vital contribution to various cellular processes. Selenium-enriched yeast (SeY) was reported to improve the health and metabolic status in broiler chicken. Hence, our study was endeavored to illustrate the mitigating efficacy of SeY on Cu-induced hepatic and renal damage. Cobb chicks aged 1 day were allocated into four experimental groups and offered a basal diet, SeY (0.5 mg/kg), CuSO4 (300 mg/kg), or SeY plus CuSO4 in their diets for 42 days. Our results revealed that SeY supplement antagonized significantly the Cu accumulation in livers and kidneys of exposed birds. Marked declines were also detected in the AST, ALT, urea, and creatinine levels, besides marked increases in total protein, glycerides, and cholesterol in the SeY-supplemented group. Moreover, enhancement of cellular antioxidant biomarkers (superoxide dismutase, CAT, GPx, and GSH) along with lowered MDA contents were achieved by SeY in hepatic and renal tissues. Further, SeY exerted a noteworthy anti-inflammatory action as indicated by decreased inflammatory biomarkers (IL-1β and TNF-α) and NO levels in both organs. Noticeable histopathological alterations of both organs further validated the changes in the markers mentioned above. To sum up, our findings indicate that SeY can be considered a potential feed supplement for alleviating Cu-induced hepatic and renal damage in broilers, possibly via activation of antioxidant molecules and lessening the inflammatory stress.

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

“…Similar outcomes were also reported by Sadek and colleagues in cadmium chloride [ 54 ] and vancomycin [ 30 ]-mediated renal stresses. The ability of selenium to quench hydrogen peroxide radicals refers to its position as a selenocysteine residue in the active site of selenoproteins, including GPx [ 65 , 66 ]. Previous studies had reported that green synthetized SeNPs with phytochemicals offered a distinguished antioxidant power than that of SeNPs alone [ 26 , 35 ].…”

The Effects of 1-Deoxynojirimycin from Mulberry on Oxidative Stress and Inflammation in Laying Hens and the Direct Effects on Intestine Epithelium Cells In Vitro

“…Maintaining intestinal health is essential for the health status of poultry. When the body is in an oxidative stress state, there is an increase in MDA and the accumulation of ROS and a decrease in SOD, CAT, and GSH-Px, which aggregates the damage to cells and tissues, causing a series of health problems [ 23 , 24 ]. Excessive oxidative stress often induces inflammation [ 25 ] and promotes cells to produce inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, and activate inflammatory responses [ 26 ].…”