Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson’s Disease

Joshaghani, Hamidreza; Hashemy, Seyed Isaac

doi:10.1007/s12291-022-01031-1

Cited by 13 publications

(6 citation statements)

References 147 publications

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“…[5] Concurrently, selenium’s impact on inflammatory pathways, highlighted by its regulation of cytokine production, aligns with emerging research on PD’s inflammatory underpinnings, including the notable roles of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as markers of neuroinflammation. [6,7] This dual capacity underscores the significance of selenium in the neurodegenerative process and supports the investigation into its levels in PD patients. [8] Furthermore, diagnostic criteria for PD emphasize clinical symptoms and advanced diagnostic tools, underscoring the importance of distinguishing PD from other neurodegenerative disorders through biomarkers and neuroimaging, reflecting the multifaceted nature of PD diagnosis and the potential of inflammation-focused research to illuminate novel therapeutic targets.…”

Section: Introductionmentioning

confidence: 67%

Association between Parkinson disease and selenium levels in the body: A systematic review and meta-analysis

Chen,

Hu,

Zhang

et al. 2024

Medicine

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Background: Parkinson disease (PD) is a common neurodegenerative disorder, but its pathogenesis is still not entirely understood. While some trace elements, such as selenium, iron, and copper, are considered pivotal in PD onset due to their role in oxidative stress, the association between selenium concentrations and PD susceptibility remains ambiguous. Methods: A systematic review and meta-analysis was conducted in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and framed by the Patient, Intervention, Comparison, Outcome paradigm. Data were sourced from 4 prominent electronic databases: PubMed, Embase, Web of Science, and Cochrane Library. Eligible studies must have had a PD case group and a control group, both of which presented data on selenium concentrations. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Results: Of 1541 initially identified articles, 12 studies comprising a total of 597 PD cases and 733 controls were selected for the meta-analysis. Pronounced heterogeneity was observed among these studies. When assessing blood selenium levels, no significant difference was found between patients with PD and the controls. However, when examining the cerebrospinal fluid, selenium levels in PD patients were significantly elevated compared to controls (standard mean difference = 1.21, 95% CI 0.04–2.39, P < .05). Subgroup analyses, sensitivity analyses, and evaluation of publication bias were performed to ensure data robustness. Conclusions: Elevated selenium levels in cerebrospinal fluid may be associated with a higher risk of Parkinson. Further prospective research is required to solidify this potential link and to offer avenues for novel therapeutic interventions or preventive measures.

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Section: Introductionmentioning

confidence: 67%

Association between Parkinson disease and selenium levels in the body: A systematic review and meta-analysis

Chen,

Hu,

Zhang

et al. 2024

Medicine

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“…Moreover, the protective efficacy of SeNPs extends to neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. A shared hallmark of SeNPs across these neurodegenerative conditions is their ability to suppress oxidative stress (Rajeshkumar et al., 2019; Salaramoli et al., 2023).…”

Section: Blood–brain Barriermentioning

confidence: 99%

Implications of environmental nanoparticles on neurodegeneration

Hermosillo‐Abundis,

Méndez‐Rojas,

Arias‐Carrión

2024

J of Neuroscience Research

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The ubiquity of nanoparticles, sourced from both natural environments and human activities, presents critical challenges for public health. While offering significant potential for innovative biomedical applications—especially in enhancing drug transport across the blood–brain barrier—these particles also introduce possible hazards due to inadvertent exposure. This concise review explores the paradoxical nature of nanoparticles, emphasizing their promising applications in healthcare juxtaposed with their potential neurotoxic consequences. Through a detailed examination, we delineate the pathways through which nanoparticles can reach the brain and the subsequent health implications. There is growing evidence of a disturbing association between nanoparticle exposure and the onset of neurodegenerative conditions, highlighting the imperative for comprehensive research and strategic interventions. Gaining a deep understanding of these mechanisms and enacting protective policies are crucial steps toward reducing the health threats of nanoparticles, thereby maximizing their therapeutic advantages.

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“…Dopamine agonists, such as pramipexole and ropinirole, are also used to stimulate the brain’s remaining dopamine receptors and thus enhance the effects of the medication. Additionally, surgical treatments such as deep brain stimulation (DBS) are being studied for their potential to relieve symptoms of Parkinson’s 101 , 102 .…”

Section: Pathophysiology Of Pd and Dementiamentioning

confidence: 99%

Parkinson’s disease updates: Addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment

Prajjwal,

Flores Sanga,

Acharya

et al. 2023

Annals of Medicine &Amp; Surgery

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After only Alzheimer’s disease (AD), Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. The incidence of this disease increases with age, especially for those above 70 years old. There are many risk factors that are well-established in the contribution to the development of PD, such as age, gender, ethnicity, rapid eye movement sleep disorder, high consumption of dairy products, traumatic brain injury, genetics, and pesticides/herbicides. Interestingly, smoking, consumption of caffeine, and physical activities are the protective factors of PD. A deficiency of dopamine in the substantia nigra of the brainstem is the main pathology. This, subsequently, alters the neurotransmitter, causing an imbalance between excitatory and inhibitory signals. In addition, genetics is also involved in the pathogenesis of the disease. As a result, patients exhibit characteristic motor symptoms such as tremors, stiffness, bradykinesia, and postural instability, along with non-motor symptoms, including dementia, urinary incontinence, sleeping disturbances, and orthostatic hypotension. PD may resemble other diseases; therefore, it is important to pay attention to the diagnosis criteria. Parkinson’s disease dementia can share common features with AD; this can include behavioral as well as psychiatric symptoms, in addition to the pathology being protein aggregate accumulation in the brain. For PD management, the administration of pharmacological treatment depends on the motor symptoms experienced by the patients. Non-pharmacological treatment plays a role as adjuvant therapy, while surgical management is indicated in chronic cases. This paper aims to review the etiology, risk factors, protective factors, pathophysiology, signs and symptoms, associated conditions, and management of PD.

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Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson’s Disease

Cited by 13 publications

References 147 publications

Association between Parkinson disease and selenium levels in the body: A systematic review and meta-analysis

Association between Parkinson disease and selenium levels in the body: A systematic review and meta-analysis

Implications of environmental nanoparticles on neurodegeneration

Parkinson’s disease updates: Addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment

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