Selenium deficiency in hypercholesterolaemic patients treated with LDL apheresis

Jaudon, M C; Assogba, U.; Bourely, B.; Dairou, F.; Bruckert, Éric; Delattre, Jacques

doi:10.1016/s0140-6736(94)90264-x

Cited by 9 publications

(7 citation statements)

References 4 publications

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“…This result allows us to confirm the hypothesis that we already proposed in a previous work [8] that the deficiency of this trace element was related to the LDL apheresis technique rather than to the hypercholesterolemic status. Two specific selenium-carrier proteins have been identified--glutathione peroxidase and selenoprotein P--constituting 15% and 40%, respectively, of total selenium [31,32].…”

Section: Discussionsupporting

confidence: 90%

“…Preliminary data suggest that LDL apheresis may result in selenium depletion [8] but does not induce vitamin E or B-carotene deficiency, when compared with normocholesterolemic subjects [9]. Given the relationship between antioxidants and cardiovascular diseases [10][11][12][13][14], we comprehensively studied the plasma levels of vitamin E, G-carotene, vitamin A, selenium, zinc, and copper in hypercholesterolemic patients treated with LDL apheresis, which is the same population that was previously studied for selenium status [8].…”

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confidence: 99%

“…Given the relationship between antioxidants and cardiovascular diseases [10][11][12][13][14], we comprehensively studied the plasma levels of vitamin E, G-carotene, vitamin A, selenium, zinc, and copper in hypercholesterolemic patients treated with LDL apheresis, which is the same population that was previously studied for selenium status [8]. In order to discriminate whether the antioxidant status was influenced by the LDL apheresis technique or by the hypercholesterolemia, we compared these results with those in a normocholesterolemic population and in hypercholesterolemic patients before treatment.…”

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confidence: 99%

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Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Lepage

Bonnefont‐Rousselot

Bruckert

et al. 1996

Cardiovasc Drug Ther

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Oxidation of low density lipoprotein is involved in the pathogenesis of atherosclerosis. Epidemiological studies suggest a negative correlation between the occurrence of cardiovascular diseases and blood concentrations of lipophilic antioxidants such as vitamins A and E and beta-carotene. Trace elements, such as selenium, zinc, and copper, are involved in the activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. The aim of this study was to determine the antioxidant and trace element status of patients with severe hypercholesterolemia who had been treated with dextran-sulphate low-density lipoprotein apheresis in comparison with two control populations, normocholesterolemic subjects and untreated hypercholesterolemic patients. Our results showed that, patients treated with LDL apheresis, compared with normocholesteromic subjects, were not deficient in vitamin E, beta-carotene, and copper, but had lower plasma levels of selenium, zinc, and vitamin A. The low selenium and vitamin A levels were due to the LDL-apheresis treatment, and the hypercholesterolemia might have provoked the low plasma levels of zinc. The study pointed out the potential benefits of supplemental selenium, zinc, and vitamin A in patients being treated with LDL apheresis.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Lepage

Bonnefont‐Rousselot

Bruckert

et al. 1996

Cardiovasc Drug Ther

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“…The treatment is efficient in preventing fatal and nonfatal cardiovascular events in patients with these conditions. [1][2][3][4][5] Nevertheless, the extracorporeal treatment per se is associated with increased production of reactive oxygen species (ROS) by granulocytes (polymorphonuclear neutrophils [PMNs]) 4 and a reduction in the antioxidant defense. 5 The increased oxidative stress can cause oxidation of biological macromolecules, including proteins and lipids.…”

mentioning

confidence: 99%

“…[1][2][3][4][5] Nevertheless, the extracorporeal treatment per se is associated with increased production of reactive oxygen species (ROS) by granulocytes (polymorphonuclear neutrophils [PMNs]) 4 and a reduction in the antioxidant defense. 5 The increased oxidative stress can cause oxidation of biological macromolecules, including proteins and lipids. 6,7 The 2 major ROS generated from activated PMNs via the myeloperoxidase (MPO) system are hydrogen peroxide (H 2 O 2 ) and hypochlorite (HOCl), 8 which can produce lipid peroxidation products, malonealdehyde (MDA), and phosphatidylcholine hydroperoxide (PCOOH) 9,10 and protein oxidation products, diotyrosine and methylguanidine, as indirect indicators of ROS and/or free radical activity.…”

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Ascorbate Supplement Reduces Oxidative Stress in Dyslipidemic Patients Undergoing Apheresis

Chien

Chang

Chen

et al. 2004

ATVB

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Objective-The effect of ascorbate treatment on apheresis-induced oxidative stress in uremic and dyslipidemic patients was evaluated. Methods and Results-We developed a chemiluminescence-emission spectrum and high-performance liquid chromatography analysis to assess the effect of ascorbate supplement on plasma reactive oxygen species (ROS) scavenging activity and oxidized lipid/protein production in hyperlipidemic and uremic patients undergoing apheresis. Apheresis was efficient in reduction of atherogenic lipoproteins, complement, fibrinogen, soluble intercellular adhesion molecule-1, and oxidative parameters including phosphatidylcholine hydroperoxide (PCOOH), malonaldehyde, methylguanidine, and diotyrosine. Apheresis itself, however, activated leukocytes to increase ROS activity and reduced the plasma ROS scavenging activity. Ascorbate administration selectively diminished apheresis-enhanced H 2 O 2 and inflammatory mediators such as tumor necrosis factor alpha (TNF-␣) and monocyte chemoattractant protein-1. Chronically dyslipidemic and uremic patients undergoing biweekly apheresis plus ascorbate treatment had lower levels of C-reactive protein and PCOOH than did those without ascorbate treatment during a 6-month follow-up study period. Conclusions-We

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'Travelers' Thyrotoxicosis'

Liel

Alkan²

1996

Arch Intern Med

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Two young adults presented with thyrotoxicosis after increased iodide ingestion in the course of backpacking trips to Central and South America, during which each of them used an iodinated preparation for water purification. In both cases, serologic tests were positive for antithyroid peroxidase antibodies, and one had a family history of immune thyroid disease. We suggest that in these two cases the condition was a variant of iodide-induced thyrotoxicosis, reflecting an inadequate response to iodide excess in association with a presumed preexisting asymptomatic immune thyroid disease. This observation adds a new consideration for travelers' consultation.

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Selenium deficiency in hypercholesterolaemic patients treated with LDL apheresis

Cited by 9 publications

References 4 publications

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Ascorbate Supplement Reduces Oxidative Stress in Dyslipidemic Patients Undergoing Apheresis

'Travelers' Thyrotoxicosis'

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