Selenium-Containing Bicyclic β-Lactams

Abstract

The first β-lactam ring system was synthesized by H. Staudinger in 1907, but β-lactams as a class of compounds became attractive only after it was established that penicillin contained a β-lactam unit as the structural feature. Over the years, countless numbers of penicillin derivatives and a variety of new β-lactam ring systems have been prepared, tested, and introduced. As a class of β-lactam derivatives, selenium-containing bicyclic β-lactams have received only a limited attention. In this review the advances in the development of synthesis methods for selenium-containing bicyclic β-lactams are presented and discussed.

Biologically significant selenium-containing heterocycles

“…Later our efforts led to the synthesis of various kinds of Se-containing -lactams via iodocyclization (Scheme 22) [210] and ring-closure metathesis (Scheme 23) [211,212]. Recently, a review about Se-containing bicyclic -lactams was published by our group [213]. Furthermore, we evaluated possible chemopreventive properties of synthesized -lactams in human prostate cancer LNCaP cells.…”