Selenium concentrations in maternal and umbilical cord blood at 24–42 weeks of gestation: basis for optimization of selenium supplementation to premature infants

Makhoul, Imad R.; Sammour, Rami N.; Diamond, Eric; Shohat, Irit; Tamir, Ada; Shamir, Raanan

doi:10.1016/j.clnu.2003.08.004

Cited by 53 publications

(40 citation statements)

References 44 publications

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“…Both copper and selenium levels were found to increase over the course of gestation; this was statistically significant for copper and close to statistical significance for selenium. This is consistent with prior studies (Galinier et al, 2005; Grandjean et al, 1992; Makhoul et al, 2004; Perveen et al, 2002). The relationships with gestational age suggest increased placental transfer over the course of gestation, perhaps to accommodate nutritional and developmental needs of the fetus.…”

Section: Discussionsupporting

confidence: 93%

Body burdens of mercury, lead, selenium and copper among Baltimore newborns

Wells

Jarrett

Lin

et al. 2011

Environmental Research

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Umbilical cord blood or serum concentrations of mercury, lead, selenium and copper were measured with inductively coupled plasma mass spectrometry in a population of 300 infants born Baltimore, Maryland. Geometric mean values were 1.37 μg/L (95% confidence interval: 1.27, 1.48) for mercury; 0.66 μg/dL (95% CI: 0.61, 0.71) for lead; and 38.62 μg/dL (95% CI: 36.73, 40.61) for copper. Mean selenium was 70.10 μg/L (95% CI: 68.69, 70.52). Mercury, selenium and copper levels were within exposure ranges reported among similar populations, whereas the distribution of lead levels was lower than prior reports; only one infant had a cord blood lead above 10 μg/dL. Levels of selenium were significantly correlated with concentrations of lead (Spearman’s ρ = 0.20) and copper (Spearman’s ρ = 0.51). Multivariable analyses identified a number of factors associated with one of more of these exposures. These included: increasing maternal age (increased lead); Asian mothers (increased mercury and lead, decreased selenium and copper); higher umbilical cord serum n-3 fatty acids (increased mercury, selenium and copper), mothers using Medicaid (increased lead); increasing gestational age (increased copper); increasing birthweight (increased selenium); older neighborhood housing stock (increased lead and selenium); and maternal smoking (increased lead). This work provides additional information about contemporary prenatal element exposures and can help identify groups at risk of atypical exposures.

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Section: Discussionsupporting

confidence: 93%

Body burdens of mercury, lead, selenium and copper among Baltimore newborns

Wells

Jarrett

Lin

et al. 2011

Environmental Research

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“…The average concentration of Se in the maternal blood was 68.5 ng/ml (Table 2). This value is similar to previously reported values from [21,22] Arctic Canada [23] and for five communities from Norway [24]. Interestingly, however, our values are much greater than those reported for another study of Se in mothers in Kayseri, Turkey [18], which ranged from 23.22 to 53.86 ng/ml with a mean value of 35.14±6.71 ng/ml.…”

Section: Discussionsupporting

confidence: 86%

“…Umbilical cord plasma concentrations of Se were also significantly greater than the maternal serum plasma concentration. These results contradict previous findings that infant cord plasma Se concentration is lower than maternal plasma concentration [18,19,21,22,[25][26][27][28]. However, we cannot be sure if the high concentration of Se in the umbilical cord results from pleasant stocks and if that maintains constant levels in the fetus via the umbilical cord vein [29].…”

Section: Discussioncontrasting

confidence: 84%

The Selenium Levels of Mothers and Their Neonates Using Hair, Breast Milk, Meconium, and Maternal and Umbilical Cord Blood in Van Basin

Özdemir

Karadaş

Pappas

et al. 2008

Biol Trace Elem Res

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The objective of the present study is to calculate linear regressions between a mother and her child with respect to their selenium concentration (ng/g) in the following traits: maternal blood and umbilical cord blood, maternal and child hair, maternal milk and child umbilical cord blood, maternal milk and meconium, maternal blood plasma, and child meconium. The data were collected at Research Hospital of the University of Yüzüncü Yil from 30 pairs of mothers and their newborn baby. The mean maternal serum Se level in 30 mothers was 68.52 +/- 3.57 ng/g and cord plasma level was 119.90 +/- 18.08 ng/g. The Se concentration in maternal and neonatal hair was 330.84 +/- 39.03 and 1,124.76 +/- 186.84 ng/g, respectively. The Se concentration of maternal milk at day 14 after delivery was determined as 68.63 +/- 7.78 ng/g (n = 13) and the concentration of Se was 418.90 +/- 45.49 ng/g (n = 22) for meconium of neonatal. There was no significant difference between maternal blood and milk Se levels. However, hair Se concentration was significantly higher than milk and maternal blood Se level. For each trait comparison, the average absolute difference in log(10)-transformed Se concentration was calculated between a mother and her child. The observed average absolute difference was compared with a test distribution of 1,000 resampled bootstrap averages where the number of samples was maintained but the relationship between a mother and her child was randomized among samples (alpha = 0.05).

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“…Eleven studies with data on both maternal and umbilical cord selenium were identified (Butler Walker et al, 2006; Kantola et al, 2004; Lorenzo Alonso et al, 2005; Makhoul et al, 2004; Micetic-Turk et al, 2000; Mistry et al, 2008; Osman et al, 2000; Rudge et al, 2009; Sakamoto et al, 2010; Schulpis et al, 2004; Wasowicz et al, 1993). Study-specific and overall maternal/cord selenium ratios are presented (Table 3, Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Selenium and maternal blood pressure during childbirth

Wells

Goldman

Jarrett

et al. 2011

J Expo Sci Environ Epidemiol

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Evidence suggests selenium concentrations outside the nutritional range may worsen cardiovascular health. This paper examines the relationship between selenium and maternal blood pressure among 270 deliveries using umbilical cord serum as a proxy for maternal exposure levels. Multivariable models used linear splines for selenium and controlled for gestational age, maternal age, race, median household income, parity, smoking, and prepregnancy body mass index. Nonparametric analysis of this dataset was used to select spline knots for selenium at 70 and 90 μg/L. When selenium was <70 μg/L, increasing selenium levels were related to a non-statistically significant decrease in blood pressure. For selenium 70 – 90 μg/L, a 1-μg/L increase was related to a 0.37 mmHg (95% confidence interval (CI): 0.005, 0.73) change in systolic and a 0.35 mmHg (0.07, 0.64) change in diastolic blood pressure. There were very few selenium values >90 μg/L. Other studies indicate that the maternal/cord selenium ratio is 1.46 (95% CI: 1.28, 1.65). This u-shaped relationship between selenium and blood pressure is consistent with a dual role of selenium as an essential micronutrient that is nonetheless a toxicant at higher concentrations; however this needs to be studied further.

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Selenium concentrations in maternal and umbilical cord blood at 24–42 weeks of gestation: basis for optimization of selenium supplementation to premature infants

Cited by 53 publications

References 44 publications

Body burdens of mercury, lead, selenium and copper among Baltimore newborns

Body burdens of mercury, lead, selenium and copper among Baltimore newborns

The Selenium Levels of Mothers and Their Neonates Using Hair, Breast Milk, Meconium, and Maternal and Umbilical Cord Blood in Van Basin

Selenium and maternal blood pressure during childbirth

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