Selenium at the Neural Barriers: AReview

Solovyev, Nikolay; Drobyshev, Evgenii; Blume, Bastian; Michalke, Bernhard

doi:10.3389/fnins.2021.630016

Cited by 43 publications

(40 citation statements)

References 251 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Se and selenoproteins may play an important role in signaling pathways that are involved in the pathogenesis of some diseases, especially IBD (107), cancer (108), thyroid dysfunction (109), and neurogenerative disorders (110). The Se status may impact the expression of nuclear factor-κB (NF-κB) transcription factors and peroxisome proliferator activated receptor (PPAR) γ, which are involved in immune cell activation that ultimately results in various stages of inflammation (107).…”

Section: Selenium Microbiota and Diseasesmentioning

confidence: 99%

“…Neurodegenerative disorders are characterized by an increase in the production of reactive oxygen species (ROS) and a decline in the blood-brain barrier function. Due to the antioxidant property of Se, some selenoproteins play a neuroprotective role (110). TXNRD, for instance, maintains the redox balance and protects the dopaminergic cells, which are prone to oxidative stress in the pathophysiology of Parkinson's disease (165).…”

Section: Selenium Microbiota and Neurological Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

et al. 2021

View full text Add to dashboard Cite

This review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host's selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host's selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteria.

show abstract

Section: Selenium Microbiota and Diseasesmentioning

confidence: 99%

Section: Selenium Microbiota and Neurological Diseasesmentioning

confidence: 99%

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Tomislav Šperanda 1 , Valentina Pavić 2 , Zdenko Lončarić 1 , Marcela Šperanda 1 *, Maja Popović 3 , Vesna Gantner 1 and Mislav Ðidara 1 Selenium (Se), an essential trace element for human and animal health, is covalently incorporated into amino acids, acts as a cofactor for antioxidant enzymes, and is involved in the maintenance of the immune system. The main goal of this investigation was to show the effect of Se supplementation, at levels slightly higher than the recommended values, combined with natural zeolite clinoptilolite on Se deposition in tissues (muscle and liver) and on the immune and antioxidative status of supplemented growing pigs.…”

Section: Selenium and Natural Zeolite Clinoptilolite Supplementation Increases Antioxidative Status And Immune Response In Growing Pigsmentioning

confidence: 99%

“…Selenium (Se) is an essential element for humans and animals but not for plants (1). The bioavailability of Se depends on the plant itself as well as on the concentration of Se in the soil (2,3).…”

Section: Introductionmentioning

confidence: 99%

Selenium and Natural Zeolite Clinoptilolite Supplementation Increases Antioxidative Status and Immune Response in Growing Pigs

et al. 2021

View full text Add to dashboard Cite

Selenium (Se), an essential trace element for human and animal health, is covalently incorporated into amino acids, acts as a cofactor for antioxidant enzymes, and is involved in the maintenance of the immune system. The main goal of this investigation was to show the effect of Se supplementation, at levels slightly higher than the recommended values, combined with natural zeolite clinoptilolite on Se deposition in tissues (muscle and liver) and on the immune and antioxidative status of supplemented growing pigs. The experiment was carried out during a 98 d period on 60 pigs. Pigs were fed a standard feed mixture based on corn and soybean and were divided into four groups, according to the level of dietary selenium supplementation as follows: C-0.3 mg/kg DM organic Se, E1-0.5 mg/kg DM sodium selenite, E2-0.5 mg/kg DM organic selenium; E3-0.5 mg/kg DM organic Se+0.2% zeolite. Higher (P < 0.05) selenium concentrations were determined in the muscle and liver in growing pigs fed with higher organic Se in combination with zeolite compared to the lower organic Se concentration. Addition of organic Se increased (P < 0.05) Se deposition in muscle and liver compared to the equal amount of inorganic Se (E2 vs. E1). Higher organic Se in combination with natural zeolite addition increases (P < 0.05) proportion of pigs' cluster of differentiation (CD)45+ compared to the same amount of inorganic Se and lower organic Se addition. The proportion of CD45+ and CD4+ lymphocytes was higher (P < 0.05) in E3 group compared to the other groups. Higher (P < 0.05) proportion of CD21+ lymphocytes were measured in the E2 and E3 groups compared with the other groups. The highest (P < 0.01) activity of glutathione peroxidase (GSH-Px) in pig erythrocytes was observed in the E3 group, while higher (P < 0.05) activity of glutathione reductase (GR) was in all experimental groups related to the control one. A dietary addition of 0.5 mg/kg DM of organic Se in combination with zeolite (0.2% DM) has increased (P < 0.05) Se deposition in liver, muscle, and blood, compared to the dietary addition of 0.3 mg/kg DM of the organic Se.

show abstract

“…Selenoprotein P (SELENOP1) is a selenium-rich protein with 10 Sec residues that transports Se in serum from liver to the brain and other organs ( 4 ). SELENOP1 is present in the cerebral spinal fluid (CSF) and in the choroid plexus, which releases CSF ( 5 , 6 ), and in glial cells ( 7 ). SELENOP1 has also been described in brain neurons ( 8 , 9 ), which may be the targets of Se transport.…”

Section: Introductionmentioning

confidence: 99%

Selenoprotein P Regulates Synaptic Zinc and Reduces Tau Phosphorylation

et al. 2021

View full text Add to dashboard Cite

Selenoprotein P (SELENOP1) is a selenium-rich antioxidant protein involved in extracellular transport of selenium (Se). SELENOP1 also has metal binding properties. The trace element Zinc (Zn2+) is a neuromodulator that can be released from synaptic terminals in the brain, primarily from a subset of glutamatergic terminals. Both Zn2+ and Se are necessary for normal brain function. Although these ions can bind together with high affinity, the biological significance of an interaction of SELENOP1 with Zn2+ has not been investigated. We examined changes in brain Zn2+ in SELENOP1 knockout (KO) animals. Timm-Danscher and N-(6-methoxy-8-quinolyl)-p-toluenesulphonamide (TSQ) staining revealed increased levels of intracellular Zn2+ in the SELENOP1−/− hippocampus compared to wildtype (WT) mice. Mass spectrometry analysis of frozen whole brain samples demonstrated that total Zn2+ was not increased in the SELENOP1−/− mice, suggesting only local changes in Zn2+ distribution. Unexpectedly, live Zn2+ imaging of hippocampal slices with a selective extracellular fluorescent Zn2+ indicator (FluoZin-3) showed that SELENOP1−/− mice have impaired Zn2+ release in response to KCl-induced neuron depolarization. The zinc/metal storage protein metallothionein 3 (MT-3) was increased in SELENOP1−/− hippocampus relative to wildtype, possibly in response to an elevated Zn2+ content. We found that depriving cultured cells of selenium resulted in increased intracellular Zn2+, as did inhibition of selenoprotein GPX4 but not GPX1, suggesting the increased Zn2+ in SELENOP1−/− mice is due to a downregulation of antioxidant selenoproteins and subsequent release of Zn2+ from intracellular stores. Surprisingly, we found increased tau phosphorylation in the hippocampus of SELENOP1−/− mice, possibly resulting from intracellular zinc changes. Our findings reveal important roles for SELENOP1 in the maintenance of synaptic Zn2+ physiology and preventing tau hyperphosphorylation.

show abstract

Selenium at the Neural Barriers: AReview

Cited by 43 publications

References 251 publications

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

Selenium and Natural Zeolite Clinoptilolite Supplementation Increases Antioxidative Status and Immune Response in Growing Pigs

Selenoprotein P Regulates Synaptic Zinc and Reduces Tau Phosphorylation

Contact Info

Product

Resources

About