Selenium and Zinc Status in Chronic Myofascial Pain: Serum and Erythrocyte Concentrations and Food Intake

Neto, João Araújo Barros; Souza‐Machado, Adelmir; Kraychete, Durval Campos; Jesus, Rosângela Passos de; Cortes, Matheus Lopes; Lima, Michele dos Santos; Freitas, Mariana Carvalho; Santos, Táscya Morganna de Morais; Viana, Gustavo Freitas de Sousa; Menezes-Filho, José A.

doi:10.1371/journal.pone.0164302

Cited by 15 publications

(11 citation statements)

References 35 publications

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“…In humans, an inadequate intake of both Zn and Se and their low intracellular stores are correlated with pain in patients with chronic myofascial pain ( 220 ) .…”

Section: Resultsmentioning

confidence: 99%

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

et al. 2018

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Emerging literature suggests that diet constituents may play a modulatory role in chronic pain (CP) through management of inflammation/oxidative stress, resulting in attenuation of pain. We performed a narrative review to evaluate the existing evidence regarding the optimum diet for the management of CP, and we built a food pyramid on this topic. The present review also describes the activities of various natural compounds contained in foods (i.e. phenolic compounds in extra-virgin olive oil (EVO)) listed on our pyramid, which have comparable effects to drug management therapy. This review included 172 eligible studies. The pyramid shows that carbohydrates with low glycaemic index should be consumed every day (three portions), together with fruits and vegetables (five portions), yogurt (125 ml), red wine (125 ml) and EVO; weekly: legumes and fish (four portions); white meat, eggs and fresh cheese (two portions); red or processed meats (once per week); sweets can be consumed occasionally. The food amounts are estimates based on nutritional and practical considerations. At the top of the pyramid there is a pennant: it means that CP subjects may need a specific customised supplementation (vitamin B12, vitamin D, n-3 fatty acids, fibre). The food pyramid proposal will serve to guide dietary intake with to the intent of alleviating pain in CP patients. Moreover, a targeted diet can also help to solve problems related to the drugs used to combat CP, i.e. constipation. However, this paper would be an early hypothetical proposal due to the limitations of the studies.

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“…In humans, an inadequate intake of both Zn and Se and their low intracellular stores are correlated with pain in patients with chronic myofascial pain ( 220 ) .…”

Section: Resultsmentioning

confidence: 99%

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

et al. 2018

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“…Barros-Neto et al . [ 160 ] investigated the relationship between chronic musculoskeletal pain and malnutrition and reported that myofascial pain is associated with changes in intracellular zinc and selenium stores caused by inadequate food intake.…”

Section: Selenium and Painmentioning

confidence: 99%

Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels

Nazıroğlu

Öz

Yıldızhan

2020

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Pain is a complex physiological process that includes many components. Growing evidence supports the idea that oxidative stress and Ca2+ signaling pathways participate in pain detection by neurons. The main source of endogenous reactive oxygen species (ROS) is mitochondrial dysfunction induced by membrane depolarization, which is in turn caused by Ca2+ influx into the cytosol of neurons. ROS are controlled by antioxidants, including selenium. Selenium plays an important role in the nervous system, including the brain, where it acts as a cofactor for glutathione peroxidase and is incorporated into selenoproteins involved in antioxidant defenses. It has neuroprotective effects through modulation of excessive ROS production, inflammation, and Ca2+ overload in several diseases, including inflammatory pain, hypersensitivity, allodynia, diabetic neuropathic pain, and nociceptive pain. Ca2+ entry across membranes is mediated by different channels, including transient receptor potential (TRP) channels, some of which (e.g., TRPA1, TRPM2, TRPV1, and TRPV4) can be activated by oxidative stress and have a role in the induction of peripheral pain. The results of recent studies indicate the modulator roles of selenium in peripheral pain through inhibition of TRP channels in the dorsal root ganglia of experimental animals. This review summarizes the protective role of selenium in TRP channel regulation, Ca2+ signaling, apoptosis, and mitochondrial oxidative stress in peripheral pain induction.

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“…Moreover, serum magnesium and zinc levels are also associated with clinical parameters in FM, indicating their potential role in the pathogenesis of the disease. [9][10][11][12] Zinc is an essential element required for various systems to function properly. It naturally exists in some foods and is also available as a dietary supplement.…”

Section: Introductionmentioning

confidence: 99%

Zinc in fibromyalgia patients: relationship with body mass index and sleep quality

Yiğit¹

2022

Eur J Clin Exp Med

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Introduction and aim. Given the potential relationship between oxidative stress and fibromyalgia and well-documented antioxidant efficacy of zinc, the present study aimed to determine serum zinc concentration in FM patients as compared to healthy controls, as well as to identify the correlation of serum zinc concentration with the body mass index (BMI) and sleep quality, Material and methods. In this case-control study, 54 fibromyalgia patients were consecutively recruited between October 01, 2021 and December 01, 2021. The control group consisted of 54 age- and sex-matched healthy controls. Results. Fibromyalgia group had significantly lower zinc concentration, higher body mass index, and lower sleep quality scores as compared to the healthy control group. The correlation analysis revealed a significantly negative correlation between serum zinc concentration and body mass index and a significantly positive correlation between serum zinc concentration and sleep quality both in fibromyalgia and healthy control groups. Conclusion. Our results both support the hypothesis that low serum zinc concentration plays a role in the pathophysiology of fibromyalgia and indicate that fibromyalgia may lead to weight gain and poor sleep quality, which needs to be confirmed in large-cohort studies.

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Selenium and Zinc Status in Chronic Myofascial Pain: Serum and Erythrocyte Concentrations and Food Intake

Cited by 15 publications

References 35 publications

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents

Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels

Zinc in fibromyalgia patients: relationship with body mass index and sleep quality

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