Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy

Moreno‐Reyes, Rodrigo; Mathieu, Françoise; Boelaert, Marleen; Begaux, Françoise; Suetens, Carl; Rivera, Maria; Nève, Jean; Perlmutter, Noémi; Vanderpas, Jean

doi:10.1093/ajcn/78.1.137

Cited by 121 publications

(70 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The geographical distribution of selenium ranges from selenium-deficient regions in China, including areas from the northeast to southwest and southeast Siberia (2,3,13,14), to selenium-rich regions in Ireland, Israel, northern Australia and the western US (15). Differences in selenium dietary intake become serious at the top of the ground food chain.…”

Section: Selenium Status and Its Biological Actionsmentioning

confidence: 99%

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

Jeong

2011

Mol Med Report

View full text Add to dashboard Cite

Abstract. Selenium is an essential biological trace element. Adult daily intake of selenium should be approximately 100 µg per day. This compound has a two-sided effect depending on its concentration. A selenium-deficient diet is associated with various endemic diseases, including cardiomuscular malfunctions, osteoarthritis, cancer and viral infections that lead to premature death. These defects are prevented when dietary intake of selenium is adequate. The preventive biological effect of selenium is considered to be due to the antioxidant function of selenoproteins with a selenocysteine in the active site of the catalytic domain. Antioxidant selenoproteins maintain the intracellular redox status and, as a result, normal physiological processes in the cell. Conversely, an overdose of selenium generates oxygen radicals and leads to apoptotic cell death by inducing oxidation and cross-linking of protein thiol groups essential for cell survival. A lower redox state caused by selenium may be implicated in toxic diseases, such as alkali disease and blind staggers. Collectively, selenium seems to have both harmful and beneficial attributes. The aim of this review is to summarize the various biological functions of selenium and to illustrate its opposite roles as a pro-oxidant and an antioxidant.

show abstract

Section: Selenium Status and Its Biological Actionsmentioning

confidence: 99%

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

Jeong

2011

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…While it has been showed that alterations in the expression of collagen type X (ColX) and parathyroid hormone related peptide, was compatible with Kashin-Beck osteoarthropathy, due to selenium and iodine deficiency 10 . Moreover, it has been reported that selenium may help prevent the occurrence of Kashin-Beck osteoarthropathy 11 . Additionally, modifiable metabolic risk factors may lead to raised cartilage loss.…”

Section: Jfsf 46mentioning

confidence: 99%

The role of Mediterranean diet and it’s components on the progress of osteoarthritis

Pitaraki¹

2017

JFSF

View full text Add to dashboard Cite

“…Second, there has been great success using Se supplementation to prevent and control KBD [9,[14][15][16][17]. However, some scientists consider that the environmental low Se was only an external condition but not the initial etiology causing KBD [18,19].…”

Section: Introductionmentioning

confidence: 99%

Hair Selenium Levels of School Children in Kashin–Beck Disease Endemic Areas in Tibet, China

Chen

Yang

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

Previous studies have shown that the selenium (Se) deficiency is an important factor for the etiology of KashinBeck disease (KBD). Although KBD is presently controlled in most regions of China, it is still active in the Tibetan Plateau. The present study aimed to assess the nutritional status of selenium in school children by using the Se level in hair as a biomarker in KBD endemic areas of Lhasa in Tibet, China. Hair samples of 155 school children aged 6-15 years were collected in both KBD areas and non-KBD areas of Lhasa in 2013. The Se level in the hair samples was determined by inductive coupled plasma mass spectrometry (ICP-MS). The average concentration of Se in children's hair was 0.232 μg/g in KBD areas of Lhasa, which was significantly higher than the data reported decades ago. A significant difference in hair Se was observed between the boys (0.255 μg/g) and the girls (0.222 μg/g) in the studied KBD areas (P<0

show abstract

Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy

Cited by 121 publications

References 21 publications

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

The role of Mediterranean diet and it’s components on the progress of osteoarthritis

Hair Selenium Levels of School Children in Kashin–Beck Disease Endemic Areas in Tibet, China

Contact Info

Product

Resources

About