Selenium and human nervous system

Ding, Wenqiang; Wang, Shuang; Gu, Jun; Yu, Lei

doi:10.1016/j.cclet.2022.108043

Cited by 22 publications

(8 citation statements)

References 87 publications

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“…The functions of this protein are poorly studied, and it does not directly cause neurodegenerative processes [ 84 , 90 ]. However, by analogy with methionine sulfoxide reductase A, it is still assumed that selenium deficiency may reduce the activity of SELENOR and increase the content of methionine sulfoxide, promoting the formation of Aβ small fiber oligomer to accelerate the development of cognitive impairment [ 91 ] ( Table 1 ).…”

Section: Role Of Selenium and Selenoproteins On Neurodegeneration In ...mentioning

confidence: 99%

Selenium Nanoparticles in Protecting the Brain from Stroke: Possible Signaling and Metabolic Mechanisms

Turovsky,

Baryshev,

Plotnikov

2024

Nanomaterials

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Strokes rank as the second most common cause of mortality and disability in the human population across the world. Currently, available methods of treating or preventing strokes have significant limitations, primarily the need to use high doses of drugs due to the presence of the blood–brain barrier. In the last decade, increasing attention has been paid to the capabilities of nanotechnology. However, the vast majority of research in this area is focused on the mechanisms of anticancer and antiviral effects of nanoparticles. In our opinion, not enough attention is paid to the neuroprotective mechanisms of nanomaterials. In this review, we attempted to summarize the key molecular mechanisms of brain cell damage during ischemia. We discussed the current literature regarding the use of various nanomaterials for the treatment of strokes. In this review, we examined the features of all known nanomaterials, the possibility of which are currently being studied for the treatment of strokes. In this regard, the positive and negative properties of nanomaterials for the treatment of strokes have been identified. Particular attention in the review was paid to nanoselenium since selenium is a vital microelement and is part of very important and little-studied proteins, e.g., selenoproteins and selenium-containing proteins. An analysis of modern studies of the cytoprotective effects of nanoselenium made it possible to establish the mechanisms of acute and chronic protective effects of selenium nanoparticles. In this review, we aimed to combine all the available information regarding the neuroprotective properties and mechanisms of action of nanoparticles in neurodegenerative processes, especially in cerebral ischemia.

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Section: Role Of Selenium and Selenoproteins On Neurodegeneration In ...mentioning

confidence: 99%

Selenium Nanoparticles in Protecting the Brain from Stroke: Possible Signaling and Metabolic Mechanisms

Turovsky,

Baryshev,

Plotnikov

2024

Nanomaterials

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“…The elements, including K, Mg, Ca, Fe, Na, Mn, Zn, Cu, Mo, Co, and Se, also were detected in this study (Table S2). Se has various functions, such as preventing various cancers [26], protecting the nervous system [27], enhancing immunity [28] and scavenging free radicals [29]. Referring to the selenium content standard (0.004-0.030 mg•100 g −1 ) by the National Standard of the People's Republic of China-Rich selenium paddy [30], 36 out of 76 samples meet this standard, with a selenium rich rate of 39.47%.…”

Section: Physicochemical Traits Of Hbmentioning

confidence: 99%

The Quality Evaluation of Highland Barley and Its Suitability for Chinese Traditional Tsampa Processing

Xia,

Yu,

Yang

et al. 2024

Foods

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The physicochemical traits of highland barley prominently affect the quality of Tsampa. To find out the relevance between the physicochemical properties of raw material and the texture parameters of processed products, twenty-five physicochemical traits and ten quality parameters for seventy-six varieties of highland barley were measured and analyzed. The results showed that there was a significant difference between the physicochemical indexes for highland barleys of various colors. The dark highland barley generally has more fat, protein, total dietary fiber, phenolic, Mg, K, Ca, and Zn and less amylose, Fe, Cu, and Mo than light colored barley. Then, these highland barleys were made into Tsampa. A comprehensive quality evaluation model based on the color and texture parameters of Tsampa was established through principal component analysis. Then, cluster analysis was used to classify the tested samples into three edible quality grades predicated on the above evaluation model. At last, the regression analysis was applied to establish a Tsampa quality predictive model according to the physicochemical traits of the raw material. The results showed that amylose, protein, β-Glucan, and a* and b* could be used to predict the comprehensive quality of Tsampa. The predicted results indicated that 11 of 14 validated samples were consistent with the actual quality, and the accuracy was above 78.57%. Our study built the approach of the appropriate processing varieties evaluation. It may provide reference for processing specific highland barley.

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“…Nano-selenium low toxicity and great bioavailability have garnered a lot of interest. The subject of biomedical nervous systems has a lot of potential applications for nano-selenium [19]. Concern concerning long-term lowlevel exposure to chemicals, pesticides, or airborne pollutants as well as neuroin ammation is currently developing.…”

Section: Introductionmentioning

confidence: 99%

Assessment of sweet whey fortified with selenium and Bifidobacteria on reduction of pesticide liver toxicity in albino rats

Moawad,

Osman,

Hassanein

et al. 2024

Preprint

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Background Deltamethrin (DLM) represents one of the most commonly used pesticides. DLM passes through milk, vegetables, and fruits to humans or through animals (veterinary drugs and feeding on contaminated forage) to milk; it can escape from skin to blood and be secreted in breast milk in lactating women. It was believed to have neurotoxic, nephrotoxic, and hepatotoxic properties. Methods In order to investigate deltamethrin-induced hepatotoxicity, 64 rats were divided into 8 groups. The control group did not receive any treatment. D 30 mg/kg DLM (body weight) dissolved in corn oil, B 1 mL whey (1010 cfu/ml of Bifidobacterium logum ATCC 15707), S 1 mL whey (0.5 ppm selenium), BS 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707 + 0.5 ppm selenium), BD 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707 + DLM), SD 1 mL whey (0.5 ppm selenium) + DLM, and BSD 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707) + 0.5 ppm selenium + DLM. Results Results marked that manipulation of bifidobacteria, or selenium triggered significant improvement in AST, ALT, GSH, TNF-α, NF-KB and BCL2 as well as reduction in histopathological necrosis, congestion, and degradation. Conclusion Whey beverage fortified with Bifidobacterium longum and selenium implicated reduction in oxidative stress, histopathological degradation that accomplished DLM toxicity. Utilization of whey (a byproduct from cheese making) is considered a recycling process which supports ecofriendly practices and sustainability.

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Selenium and human nervous system

Cited by 22 publications

References 87 publications

Selenium Nanoparticles in Protecting the Brain from Stroke: Possible Signaling and Metabolic Mechanisms

Selenium Nanoparticles in Protecting the Brain from Stroke: Possible Signaling and Metabolic Mechanisms

The Quality Evaluation of Highland Barley and Its Suitability for Chinese Traditional Tsampa Processing

Assessment of sweet whey fortified with selenium and Bifidobacteria on reduction of pesticide liver toxicity in albino rats

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