Selenium and Glutathione Peroxidase Levels in Sickle Cell Anemia

Natta, Clayton; Chen, L.C.; Chow, Ching K.

doi:10.1159/000205188

Cited by 45 publications

(30 citation statements)

References 5 publications

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“…Natta et al 18 measured Se levels and GSHPx activity in whole blood and plasma of patients with sickle cell anemia and reported a signi®cant decrease compared with controls. Selenium concentration has a direct relationship with GSHPx activity.…”

Section: Resultsmentioning

confidence: 99%

Comparison of the selenium level with GSH‐Px activity in the liver of mice treated with 7,12 DMBA

Batçıoğlu

Öztürk

Karagözler

et al. 2001

Cell Biochemistry & Function

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In this study, the relationship between selenium (Se) and glutathione peroxidase (GSHPx) levels was investigated in 7,12-dimethylbenz(a)anthracene (7,12-DMBA)-treated mouse liver. The potential mammary carcinogen 7,12-DMBA, was injected intraperitoneally (20 mg kg(-1) day(-1)) into 10-12 month old female mice. After 21 days of application the mice were sacrificed and GSHPx and Se levels of liver homogenates were measured. Se and GSHPx levels in 7,12-DMBA-treated mice were significantly lower than those of controls (p < 0.05). The control group exhibited 0.9 +/- 0.066 U mg(-1) protein and 0.86 +/- 0.058 p.p.m. levels of GSHPx and Se respectively. The 7,12-DMBA-treated group had significantly (p < 0.05) decreased GSHPx and Se levels (0.42 +/- 0.062 U mg(-1) protein and 0.69 +/- 0.034 p.p.m. respectively). The results show a direct relationship between Se and GSHPx activity and a negative correlation between antioxidant capacity and existence of a carcinogen in metabolism.

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Section: Resultsmentioning

confidence: 99%

Comparison of the selenium level with GSH‐Px activity in the liver of mice treated with 7,12 DMBA

Batçıoğlu

Öztürk

Karagözler

et al. 2001

Cell Biochemistry & Function

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“…146,147 Vitamin E has anti-oxidant properties that could protect red cells against oxidative stress and its administration leads to a decrease in the percentage of irreversibly sickled cells, which might alleviate symptoms. 148 Deficiency of vitamins C 149 and D 150 and of minerals such as magnesium 151 and selenium 152 has been reported, although the exact pathophysiological consequences and contribution to growth delay in SCD are unclear. The potential benefits of individual nutrient or multi-micronutrient supplementation remain to be established.…”

Section: Micronutrient Deficiencymentioning

confidence: 99%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

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Background: Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarises evidence of nutritional status in children with SCD in relation to anthropometric status, disease severity, body composition, energy metabolism, micronutrient deficiency and endocrine dysfunction. Methods: A literature search was conducted on the Medline/PUBMED, SCOPUS, SciELO and LILACS databases to July 2007 using the keywords sickle cell combined with nutrition, anthropometry, growth, height and weight, body mass index, and specific named micronutrients. Results: Forty-six studies (26 cross-sectional and 20 longitudinal) were included in the final anthropometric analysis. Fourteen of the longitudinal studies were conducted in North America, the Caribbean or Europe, representing 78.8% (2086/2645) of patients. Most studies were observational with wide variations in sample size and selection of reference growth data, which limited comparability. There was a paucity of studies from Africa and the Arabian Peninsula, highlighting a large knowledge gap for low-resource settings. There was a consistent pattern of growth failure among affected children from all geographic areas, with good evidence linking growth failure to endocrine dysfunction, metabolic derangement and specific nutrient deficiencies. Conclusions: The monitoring of growth and nutritional status in children with SCD is an essential requirement for comprehensive care, facilitating early diagnosis of growth failure and nutritional intervention. Randomised controlled trials are necessary to assess the potential benefits of nutritional interventions in relation to growth, nutritional status and the pathophysiology of the disease.

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“…However, the few studies that have examined antioxidant enzymes in RBCs of patients or mice with SCD have yielded contradictory results with respect to RBC levels of SOD, catalase, and GPx (37,43). The activation status of antioxidant enzymes in RBCs of individuals with SCD and the expression of the more recently discovered Prx enzymes have not been examined.…”

mentioning

confidence: 99%

Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia

Cho

Kato

Yang

et al. 2010

Antioxidants & Redox Signaling

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Chronic redox imbalance in erythrocytes of individuals with sickle cell disease (SCD) contributes to oxidative stress and likely underlies common etiologies of hemolysis. We measured the amounts of six antioxidant enzymes-SOD1, catalase, glutathione peroxidase 1 (GPx1), as well as peroxiredoxins (Prxs) I, II, and VI-in red blood cells (RBCs) of SCD patients and control subjects. The amounts of SOD1 and Prx VI were reduced by about 17% and 20%, respectively, in SCD RBCs compared with control cells. The amounts of Prx II and GPx1 did not differ between SCD and normal RBCs. However, about 18% of Prx II was inactivated in SCD RBCs as a result of oxidation to sulfinic Prx II, whereas inactive Prx II was virtually undetectable in control cells. Furthermore, GPx1 activity was reduced by about 33% in SCD RBCs, and the loss of activity was correlated with hemolysis in SCD patients. RBCs from SCD patients taking hydroxyurea demonstrated 90% higher GPx1 activity than did those from untreated SCD patients, with no differences seen for the other catalytic antioxidants. Hydroxyurea induced GPx1 expression in multiple cultured cell lines in a manner dependent on both p53 and NO-cGMP signaling pathways. GPx1 expression represents a previously unrecognized potential benefit of hydroxyurea treatment in SCD patients. Antioxid. Redox Signal. 13, 1-11.

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Selenium and Glutathione Peroxidase Levels in Sickle Cell Anemia

Cited by 45 publications

References 5 publications

Comparison of the selenium level with GSH‐Px activity in the liver of mice treated with 7,12 DMBA

Comparison of the selenium level with GSH‐Px activity in the liver of mice treated with 7,12 DMBA

Growth and nutritional status of children with homozygous sickle cell disease

Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia

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