Selenium and Glutathione Peroxidase Levels in Premature Infants in a Low Selenium Community (Christchurch, New Zealand)

Sluis, Karl B.; Darlow, Brian A; George, Peter M.; Mogridge, N; Dolamore, B; Winterbourn, Christine C.

doi:10.1203/00006450-199208000-00013

Cited by 46 publications

(39 citation statements)

References 26 publications

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“…Reports showed no significant differences between preterm and term milk (Aquilio et al 1996;Ladodo et al 1997) except at 1 week (Perrone et al 1993). In addition, the Se concentrations in preterm milk reported by Campfield et al (1987), Smith et al (1991) and Sluis et al (1992) were within the range of Se reported for term milk (Table 4).…”

Section: Maternal Constitutional Factorssupporting

confidence: 79%

“…The superiority of breast milk in maintaining higher Se status was shown in both term and preterm infants (Smith et al 1982(Smith et al , 1991Kumpulainen et al 1987;Bratter et al 1991b;Dolamore et al 1992;Johnson et al 1993;McGuire et al 1993a;Jochum et al 1995;Rossipal & Tiran, 1995;Daniels et al 1997;Lonnerdal & Hernell, 1994;Friel et al 1999;Sievers et al 2001). Studies showing a higher Se status in breast-fed infants compared total Se intake, milk sources and supplemental Se forms.…”

Section: Breast-feeding and The Infant's Selenium Statusmentioning

confidence: 99%

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Selenium and breast-feeding

Dórea

2002

Br J Nutr

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The objective of the present review is to discuss Se nutrition during breast-feeding, encompassing environmental and maternal constitutional factors affecting breast-milk-Se metabolism and secretion. A literature search of Medline and Webofscience was used to retrieve and select papers dealing with Se and breast milk. Although Se in natural foods occurs only in organic form, breast milk responds to organic and inorganic Se in supplements. Inorganic Se (selenite, selenate), which is largely used in maternal supplements, is not detectable in breast milk. The mammary-gland regulating mechanism controls the synthesis and secretion of seleno-compounds throughout lactation, with a high total Se level in colostrum that decreases as lactation progresses. Se appears in breast milk as a component of specific seleno-proteins and selenoamino-acids in milk proteins that are well tolerated by breast-fed infants even in high amounts. Se in breast milk occurs as glutathione peroxidase (4 -32 % total Se) . selenocystamine . selenocystine . selenomethionine. The wide range of breast-milk Se concentrations depends on Se consumed in natural foods, which reflects the Se content of the soils where they are grown. Se prophylaxis, either through soil Se fertilization or maternal supplements, is effective in raising breast-milk Se concentration. In spite of wide variation, the median Se concentration from studies worldwide are 26, 18, 15, and 17 mg/l in colostrum (0 -5 d), transitional milk (6 -21 d), mature milk (1 -3 months) and late lactation (.5 months) respectively. Se recommendations for infants are presently not achieved in 30 % of the reported breast-milk Se concentrations; nevertheless Se status is greater in breast-fed than in formula-fed infants.

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Section: Maternal Constitutional Factorssupporting

confidence: 79%

Section: Breast-feeding and The Infant's Selenium Statusmentioning

confidence: 99%

Selenium and breast-feeding

Dórea

2002

Br J Nutr

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“…New Zealand, particularly in the southern region, is selenium deficient and low glutathione peroxidase activity has been shown in adults and infants in this region. '3 14 Very low birthweight infants in this study had some of the lowest glutathione peroxidase activities reported. Glutathione peroxidase is a protective antioxidant enzyme and the reduced activity in these infants will increase their vulnerability to radical damage.29 30 The inability to show any significant difference between activities of Fl110 glutathione peroxidase in relation to respiratory outcome in our study may be due to the fact that the values are uniformly extremely low.…”

Section: Discussionmentioning

confidence: 62%

Lipid peroxidation as a measure of oxygen free radical damage in the very low birthweight infant.

Inder

Graham

Sanderson

et al. 1994

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…27 We elected not to measure GSHPx because it has been found to be a poor index in premature infants, 28 with low correlation with selenium levels. 19,29 We chose to use serum selenium because we desired a reliable selenium index that responds relatively quickly to nutritional supplementation. 29,30 Selenium has been linked to abnormal thyroid hormone metabolism by animal studies, 31,32 by epidemiological data, 1,2,7 and by clinical studies in humans.…”

Section: Discussionmentioning

confidence: 99%

“…19,29 We chose to use serum selenium because we desired a reliable selenium index that responds relatively quickly to nutritional supplementation. 29,30 Selenium has been linked to abnormal thyroid hormone metabolism by animal studies, 31,32 by epidemiological data, 1,2,7 and by clinical studies in humans. 4,33 Selenium deficiency has also been linked to euthyroid sick syndrome, 33 which might have a similar etiology to the transient hypothyroidism frequently seen in extremely premature infants.…”

Section: Discussionmentioning

confidence: 99%