Selenium and exposure to fibrogenic mineral dust: A mini-review

Muzembo, Basilua Andre; Deguchi, Yoshizumi; Ngatu, Nlandu Roger; Eitoku, Masamitsu; Hirota, Ryoji; Suganuma, Narufumi

doi:10.1016/j.envint.2015.01.002

Cited by 18 publications

(4 citation statements)

References 121 publications

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“…Mechanistically, inhalation of crystalline silica dust can induce strong inflammatory response, which is an important factor for the occurrence and development of pneumoconiosis and lung cancer. 9 Pulmonary inflammation is initiated by macrophages and dendritic cells after being exposed to nanoparticles, and a variety of substances such as cytokines and chemokines can not only lead to the formation of a persistent inflammatory micro-environment in the local lung tissue but also cause epithelial cell injury and proliferation. 10 Besides, under such conditions, pulmonary fibroblasts transdifferentiated into myofibroblasts cause collagen oversynthesis and secretion, eventually resulting in pulmonary fibrosis and pneumoconiosis.…”

Section: Introductionmentioning

confidence: 99%

Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK

Zhang

Hao

et al. 2018

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK

Zhang

Hao

et al. 2018

RSC Adv.

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“…Individuals exposed to fibrogenic mineral dust may exhibit an impaired antioxidant system and produce high levels of reactive oxygen and nitrogen species through immune cells, contributing to the perturbation of immune cell function, inflammation, fibrosis, and lung cancer (Muzembo et al 2015). Previous studies have reported that diseases such as silicosis, tuberculosis, scleroderma, and rheumatoid arthritis may originate from exposure to silica (Ehrlich et al 2006; Gibbons 2000; Mannetje et al 2002; Noonan et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Oxidative potential (OP) and mineralogy of iron ore particulate matter at the Gol-E-Gohar Mining and Industrial Facility (Iran)

Soltani

Keshavarzi

Sorooshian

et al. 2017

Environ Geochem Health

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Concentrations of total suspended particulate matter, particulate matter with aerodynamic diameter <2.5 μm (PM2.5), particulate matter <10 μm (PM10), and fallout dust were measured at the Iranian Gol-E-Gohar Mining and Industrial Facility. Samples were characterized in terms of mineralogy, morphology, and oxidative potential. Results show that indoor samples exceeded the 24-h PM2.5 and PM10 mass concentration limits (35 and 150 μg m−3, respectively) set by the US National Ambient Air Quality Standards. Calcite, magnetite, tremolite, pyrite, talc, and clay minerals such as kaolinite, vermiculite, and illite are the major phases of the iron ore PM. Accessory minerals are quartz, dolomite, hematite, actinolite, biotite, albite, nimite, laumontite, diopside, and muscovite. The scanning electron microscope structure of fibrous-elongated minerals revealed individual fibers in the range of 1.5 nm to 71.65 μm in length and 0.2 nm to 3.7 μmin diameter. The presence of minerals related to respiratory diseases, such as talc, crystalline silica, and needle-shaped minerals like amphibole asbestos (tremolite and actinolite), strongly suggests the need for detailed health-based studies in the region. The particulate samples show low to medium oxidative potential per unit of mass, in relation to an urban road side control, being more reactive with ascorbate than with glutathione or urate. However, the PM oxidative potential per volume of air is exceptionally high, confirming that the workers are exposed to a considerable oxidative environment. PM released by iron ore mining and processing activities should be considered a potential health risk to the mine workers and nearby employees, and strategies to combat the issue are suggested.

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“…Particles can penetrate the alveolar region of the lungs and the pulmonary parenchyma. Under chronic exposure conditions, the accumulation of crystalline silica leads to an inflammatory response, which can lead to silicosis, in addition to other pulmonary diseases such as bronchitis, COPD, tuberculosis, and autoimmune diseases, as well as lung cancer (Brasil, 2010; Chan et al, 2018a; Leung et al, 2012; Liu et al, 2015; Muzembo et al, 2015; Sellamuthu et al, 2012).…”

Section: Occupational Exposure To Silica and Health Effectsmentioning

confidence: 99%

Occupational exposure to crystalline silica and peripheral biomarkers: An update

Peruzzi

Brucker

Bubols

et al. 2021

J of Applied Toxicology

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Peripheral biomarkers are important tools for detecting occupational exposures to prevent the onset and/or progression of diseases. Studies that reveal early peripheral biomarkers are highly important to preserve the health of workers and can potentially contribute to diagnosing and/or prognosing occupational pathologies. Exposure to crystalline silica is a problem in several workplaces because it increases the risk of chronic obstructive pulmonary disease (COPD), tuberculosis, cancer, and pulmonary fibrosis, clinically defined as silicosis. Silicosis is diagnosed by chest radiography and/or lung tomography in advanced stages when there is a severe loss of lung function. Peripheral biomarkers can help in diagnosing early changes prior to silicosis and represent a highly important technical‐scientific advance that is minimally invasive. This review aimed to investigate the biomarkers studied for evaluating occupational exposure to crystalline silica and to understand the recent advances in this area. Potential oxidative, inflammatory, and immunological biomarkers were reviewed, as well as routine biomarkers such as biochemical parameters. It was found that biomarkers of effect such as serum CC16 and l‐selectin levels could represent promising alternatives. Additionally, studies have shown that neopterin levels in urine and serum can be used to monitor worker exposure. However, further studies are needed that include a greater number of participants, different times of exposure to crystalline silica, and a combination of silicosis patients and healthy volunteers. Evaluating the concentration of crystalline silica in occupational environments, its impact on biomarkers of effect, and alterations in lung function could contribute to revealing early health alterations in workers in a more robust manner.

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Selenium and exposure to fibrogenic mineral dust: A mini-review

Cited by 18 publications

References 121 publications

Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK

Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK

Oxidative potential (OP) and mineralogy of iron ore particulate matter at the Gol-E-Gohar Mining and Industrial Facility (Iran)

Occupational exposure to crystalline silica and peripheral biomarkers: An update

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