Selenium, a dietary-antioxidant with cardioprotective effects, prevents the impairments in heart rate and systolic blood pressure in adolescent rats exposed to binge drinking treatment

Ojeda, María Luisa; Sánchez-Sobrino, Paula; Rua, Rui Manuel; Gallego-López, María del Carmen; Nogales, Fátima; Carreras, Olimpia

doi:10.1080/00952990.2021.1973485

Cited by 8 publications

(7 citation statements)

References 55 publications

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“…Adolescence is a complex period, which involves many different hormonal pathways that orchestrate physical and biological changes, encompassing increased growth and metabolic rate, alterations in fat and muscle, and breast and genital development (Khan, 2019; Vijayakumar et al., 2018). In this context, BD consumption during adolescence has recently been associated with hepatic damage (Taylor & Miloh, 2019), increased heart rate (Ojeda et al., 2021; Ramírez‐Piña et al., 2021), reduced microvasculature function (Bian et al., 2018), kidney ionic imbalance (Sobrino et al., 2019) and even insulin disturbances (Steiner & Lang, 2017), which are situations that predispose adolescents to future adult cardiometabolic problems (Ojeda et al., 2022). Furthermore, the adolescent heart is substantially more sensitive to these effects than the adult one (Ai et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Adipose tissue homeostasis orchestrates the oxidative, energetic, metabolic and endocrine disruption induced by binge drinking in adolescent rats

Romero‐Herrera,

Nogales,

Gallego‐López

et al. 2023

The Journal of Physiology

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Binge drinking (BD) is the most common alcohol consumption model for adolescents, and has recently been related to the generation of high oxidation and insulin resistance (IR). White adipose tissue (WAT) is a target organ for insulin action that regulates whole‐body metabolism by secreting adipokines. The present study aimed to analyse the oxidative, inflammatory, energetic and endocrine profile in the WAT of BD‐exposed adolescent rats, to obtain an integrative view of insulin secretion and WAT in IR progression. Two groups of male adolescent rats were used: control (n = 8) and BD (n = 8). An intermittent i.p. BD model (20% v/v) was used during 3 consecutive weeks. BD exposure led to a pancreatic oxidative imbalance, which was joint to high insulin secretion by augmenting deacetylase sirtuin‐1 (SIRT‐1) pancreatic expression and serum adipsin levels. However, BD rats had hyperglycaemia and high homeostasis model assessment of insulin resistance value (HOMA‐IR). BD exposure in WAT increased lipid oxidation, as well as decreased insulin receptor substrate 1 (IRS‐1) and AKT expression, sterol regulatory element‐binding protein 1 (SREBP1), forkhead box O3A (FOXO3a) and peroxisome proliferator‐activated receptor γ (PPARγ), and adipocyte size. BD also affected the expression of proteins related to energy balance, such as SIRT‐1 and AMP activated protein kinase (AMPK), affecting the adipokine secretion profile (increasing resistin/adiponectin ratio). BD altered the entire serum lipid profile, increasing the concentration of free fatty acids. In conclusion, BD led to an oxidative imbalance and IR process in WAT, which modified the energy balance in this tissue, decreasing the WAT lipogenic/lipolytic ratio, affecting adipokine secretion and the systemic lipid profile, and contributing to the progression of IR. Therefore, WAT is key in the generation of metabolic and endocrine disruption after BD exposure during adolescence in rats. imageKey points Adolescent rat binge drinking (BD) exposure leads to hepatic and systemic oxidative stress (OS) via reactive oxygen species generation, causing hepatic insulin resistance (IR) and altered energy metabolism. In the present study, BD exposure in adolescent rats induces OS in the pancreas, with increased insulin secretion despite hyperglycaemia, indicating a role for IR in white adipose tissue (WAT) homeostasis. In WAT, BD produces IR and an oxidative and energetic imbalance, triggering an intense lipolysis where the serum lipid profile is altered and free fatty acids are increased, consistent with liver lipid accumulation and steatosis. BD exposure heightens inflammation in WAT, elevating pro‐inflammatory and reducing anti‐inflammatory adipokines, favouring cardiovascular damage. This research provides a comprehensive view of how adolescent BD in rats impacts liver, WAT and pancreas homeostasis, posing a risk for future cardiometabolic complications in adulthood.

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Section: Introductionmentioning

confidence: 99%

Adipose tissue homeostasis orchestrates the oxidative, energetic, metabolic and endocrine disruption induced by binge drinking in adolescent rats

Romero‐Herrera,

Nogales,

Gallego‐López

et al. 2023

The Journal of Physiology

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“…Moreover, FSTL-1 promotes endothelial cell function and revascularization, maintains cardiac growth and development, and protects the liver from fibrosis. 30 In fact, previous studies obtained in similar BD experimental models, demonstrated that BD led to OS, inflammation and apoptosis in hepatocytes 5,33 and cardiac myocytes, 18 increasing endothelial markers and blood pressure. Therefore, selenite supplementation improved not only SKM mass, but also endocrine, liver and cardiac function, positioning itself as a broad-spectrum therapy against alcohol consumption during adolescence.…”

Section: Selenite Supplementation Improved the Autocrine/ Paracrine R...mentioning

confidence: 92%

Selenium supplementation via modulation of selenoproteins ameliorates binge drinking-induced oxidative, energetic, metabolic, and endocrine imbalance in adolescent rats’ skeletal muscle

Romero-Herrera,

Nogales,

Gallego-López

et al. 2024

Food Funct.

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“…In addition to anti-osteoporotic drugs, natural products, such as trace elemental particles that are safe for human health, can be used in conjunctive therapy. Selenium may be used as an adjuvant for the treatment of osteoporosis, as some studies have demonstrated that selenium exerts cardiovascular protective and anti-osteoporotic effects [276][277][278][279][280].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

The Effects of Selenium on Bone Health: From Element to Therapeutics

et al. 2022

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Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversial. Selenium, an important trace element, is required for selenoprotein synthesis and acts crucially for proper growth and skeletal development. However, the intake of an optimum amount of selenium is critical, as both selenium deficiency and toxicity are hazardous for health. In this review, we have systematically analyzed the existing literature in this field to determine whether dietary or serum selenium concentrations are associated with bone health. In addition, the mode of administration of selenium as a supplement for treating bone disease is important. We have also highlighted the importance of using green-synthesized selenium nanoparticles as therapeutics for bone disease. Novel nanobiotechnology will be a bridgehead for clinical applications of trace elements and natural products.

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Selenium, a dietary-antioxidant with cardioprotective effects, prevents the impairments in heart rate and systolic blood pressure in adolescent rats exposed to binge drinking treatment

Cited by 8 publications

References 55 publications

Adipose tissue homeostasis orchestrates the oxidative, energetic, metabolic and endocrine disruption induced by binge drinking in adolescent rats

Adipose tissue homeostasis orchestrates the oxidative, energetic, metabolic and endocrine disruption induced by binge drinking in adolescent rats

Selenium supplementation via modulation of selenoproteins ameliorates binge drinking-induced oxidative, energetic, metabolic, and endocrine imbalance in adolescent rats’ skeletal muscle

The Effects of Selenium on Bone Health: From Element to Therapeutics

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