Selenium: A Cure for Autoimmune Thyroiditis

Giammanco, Marco; Giammanco, Manfredi Marco

doi:10.2174/1871530320666201014150147

Cited by 2 publications

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“…Some studies have shown that antioxidants may have therapeutic effects in preventing AIT and selenium is significant in antioxidation [ 1 ]. Selenium is essential in the molecular structure of thyroid enzymes, including glutathione peroxidase, which defends the thyroid against the oxidative damage caused by hydrogen peroxide enzyme synthesis by thyroid hormones [ 12 ]. All these factors indicate that selenium has broad application prospects in the treatment and prognosis of AIT.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Selenium Supplementation in the Treatment of Autoimmune Thyroiditis: An Overview of Systematic Reviews

et al. 2023

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Objective: The available evidence on selenium supplementation in the treatment of autoimmune thyroiditis (AIT) was inconclusive. This research serves to assess the effects of selenium supplementation in the treatment of AIT. Methods: Online databases including PubMed, Web of Science, Embase, and the Cochrane Library were searched from inception to 10 June 2022. The AMSTAR-2 tool was used to assess the methodological quality of included studies. The information on the randomized controlled trials of the included studies was extracted and synthesized. The GRADE system was used to assess the certainty of evidence. Results: A total of 6 systematic reviews with 75 RCTs were included. Only one study was rated as high quality. The meta-analysis showed that in the levothyroxine (LT4)-treated population, thyroid peroxidase antibody (TPO-Ab) levels decreased significantly in the selenium group at 3 months (SMD = −0.53, 95% CI: [−0.89, −0.17], p < 0.05, very low certainty) and 6 months (SMD = −1.95, 95% CI: [−3.17, −0.74], p < 0.05, very low certainty) and that thyroglobulin antibody (Tg-Ab) levels were not decreased. In the non-LT4-treated population, TPO-Ab levels decreased significantly in the selenium group at 3 and 6 months and did not decrease at 12 months. Tg-Ab levels decreased significantly in the selenium group at 3 and 6 months and did not decrease at 12 months. The adverse effects reported in the selenium group were not significantly different from those in the control group, and the certainty of evidence was low. Conclusion: Although selenium supplementation might reduce TPO-Ab levels at 3 and 6 months and Tg-Ab levels at 3 and 6 months in the non-LT4-treated population, this was based on a low certainty of evidence.

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Section: Introductionmentioning

confidence: 99%

The Effects of Selenium Supplementation in the Treatment of Autoimmune Thyroiditis: An Overview of Systematic Reviews

et al. 2023

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The role of selenium in autoimmune thyroiditis

Giammanco,

Bonfiglio,

Giammanco

et al. 2024

J Biol Res

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Selenium (Se) is an essential trace element of fundamental importance for human health. Se is incorporated into selenoproteins (SPs) which are endowed with pleiotropic effects including antioxidant and anti-inflammatory effects and active production of thyroid hormones. It has also been suggested that Se plays a crucial role in the pathogenesis of various human diseases. The therapeutic effects of supplementation with Se have already been described in various thyroid diseases. However, there are still conflicting results regarding the optimal dose of Se to administer and the duration of treatment, efficacy, and safety. The highly beneficial effects of supplementation with Se have been observed in subjects with thyroid disease in the hyperthyroid phase. In line with these observations, clinical studies have shown that in patients with Basedow's disease (BD) and autoimmune thyroiditis (AT), treatment with a combination of antithyroid drugs and Se restores the euthyroid state faster than administration of antithyroid drugs alone. However, the efficacy of this therapeutic approach remains to be better evaluated.

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Selenium: A Cure for Autoimmune Thyroiditis

Cited by 2 publications

References 0 publications

The Effects of Selenium Supplementation in the Treatment of Autoimmune Thyroiditis: An Overview of Systematic Reviews

The Effects of Selenium Supplementation in the Treatment of Autoimmune Thyroiditis: An Overview of Systematic Reviews

The role of selenium in autoimmune thyroiditis

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