“…16,17 In clinical trials with STS, it has been shown to be efficacious and safe in patients with MDD; there were no reports of hypertensive crisis associated with STS, and 6 of the 7 clinical trials were conducted without dietary modifications at any dose. 18 A metaanalysis of all 5 short-term trials evaluating treatment effects of STS for patients with MDD has been previously reported. 20 According to the results, STS demonstrated significant treatment effects on core depression symptoms (HAM-D Bech 6 items: depressed mood, guilt, work and activities, retardation, psychic anxiety, general somatic symptoms), reverse vegetative symptoms (oversleeping, overeating), motor retardation, suicide, and genital symptoms (libido).…”