Selectivity optimization in green chromatography by gradient stationary phase optimized selectivity liquid chromatography

Chen, Kai; Lynen, Frédéric; Beer, Maarten De; Hitzel, Laure; Ferguson, Paul; Hanna-Brown, Melissa; Sandra, Patrick

doi:10.1016/j.chroma.2010.09.029

Cited by 43 publications

(19 citation statements)

References 42 publications

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“…The use of multiple solid stationary phases in stationary phase-optimized selectivity liquid chromatography (SOSLC) furnishes another approach to enhance separation [22][23][24][25]. In DMCC, separation can be enhanced by the use of multiple liquid stationary phases.…”

Section: Discussionmentioning

confidence: 99%

Dispersed Mobile-Phase Countercurrent Chromatography

Xue

2016

Separations

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Countercurrent distribution based on liquid-liquid partition is a powerful separation method with minimal incurrence of loss of solutes, but its industrial application has been limited by cumbersome shifting of immiscible solvents. Although centrifugation has been employed to facilitate equilibration between phases, process scaling-up remains difficult. In this study, a dispersed mobile-phase countercurrent chromatography (DMCC) method has been developed to adapt the countercurrent distribution principle to a continuous column chromatography format. Continuous solute exchange between two immiscible phases within a series of separation columns is achieved by mechanical dispersion of an influx of mobile phase into an upward stream of small droplets travelling through the columns filled with stationary phase. The diameter, length, and number of columns, and the number of stationary phases employed in the different columns can be varied to match the requisite scale and resolution of operation. Illustrations of DMCC were provided by examples of solute separations where the fractionated solutes could be collected either from the eluate of the series of columns, or from drainage of the stationary phases in the individual columns at the end of a chromatographic run.

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Section: Discussionmentioning

confidence: 99%

Dispersed Mobile-Phase Countercurrent Chromatography

Xue

2016

Separations

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“…In particular, the reliability and performance of several relevant detection techniques (especially mass spectrometry, refractive index detection and electrochemical detection) have been considerably improved [20]. In addition to the use of isocratic elution, the advantages and benefits of POPLC include optimized analysis time by software, high sample throughput, recycling of the mobile phase, adaptable column length, no guard column, fast method development and optimization of existing methods [22,25].…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of X-ray contrast agent iomeprol in human plasma by on-line solid-phase extraction coupled with phase optimized liquid chromatography

Zhou

Tao

et al. 2015

Journal of Chromatography B

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“…This methodology is often referred to as stationary phase optimized selectivity liquid chromatography (SOSLC) [3,4]. This SOSLC approach has been commercialized under the name of POPLC (as phase optimized liquid chromatography, provided by Bischoff Chromatography), and several studies have reported the possible increase in selectivity resulting in improved separation quality, compared to the use of a single column [5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%