Selectivity in analytical chemistry (IUPAC Recommendations 2001)

Vessman, Jörgen; Stefan, Raluca‐Ioana; Staden, Jacobus Frederick van; Danzer, Klaus; Lindner, Wolfgang; Burns, D. Thorburn; Fajgelj, A.; Müller, Helmut

doi:10.1351/pac200173081381

Cited by 242 publications

(150 citation statements)

References 22 publications

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“…Selectivity, sometimes termed specificity despite contrary recommendations [59], means that the sensor responds only to the target analyte and not to other similar molecules. Generally speaking, label-free biosensors cannot distinguish between specific and nonspecific interactions except by probe selectivity, regardless of the readout method.…”

Section: Selectivitymentioning

confidence: 99%

Label‐Free Impedance Biosensors: Opportunities and Challenges

2007

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Impedance biosensors are a class of electrical biosensors that show promise for point-of-care and other applications due to low cost, ease of miniaturization, and label-free operation. Unlabeled DNA and protein targets can be detected by monitoring changes in surface impedance when a target molecule binds to an immobilized probe. The affinity capture step leads to challenges shared by all label-free affinity biosensors; these challenges are discussed along with others unique to impedance readout. Various possible mechanisms for impedance change upon target binding are discussed. We critically summarize accomplishments of past label-free impedance biosensors and identify areas for future research.

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Section: Selectivitymentioning

confidence: 99%

Label‐Free Impedance Biosensors: Opportunities and Challenges

2007

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“…The most recent IUPAC recommendation on the terminology for selectivity [20] discussed both single channel and multichannel selectivity but did not mention the differences between these concepts. Therefore the present work may complement that recommendation in this respect.…”

Section: Comparison Of the Single Channel And Multichannel Selectivitmentioning

confidence: 99%

Comparison of the single channel and multichannel (multivariate) concepts of selectivity in analytical chemistry

Dorkó

Verbić

Horvai

2015

Talanta

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Cite this article as: Zsanett Dorkó, Tatjana Verbić and George Horvai, Comparison of the single channel and multichannel(multivariate) concepts of selectivity in analytical chemistry, Talanta, http://dx.doi.org/10.1016/j.talanta. 2015.02.030 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. www.elsevier.com This accepted author manuscript is copyrighted and published by Elsevier. AbstractDifferent measures of selectivity are in use for single channel and multichannel linear analytical measurements, respectively. It is important to understand that these two measures express related but still distinctly different features of the respective measurements. These relationships are clarified by introducing new arguments. The most widely used selectivity measure of multichannel linear methods (which is based on the net analyte signal, NAS, concept) expresses the sensitivity to random errors of a determination where all bias from interferents is computationally eliminated using pure component spectra. The conventional selectivity measure of single channel linear measurements, on the other hand, helps to estimate the bias caused by an interferent in a biased measurement. In single channel methods expert knowledge about the samples is used to limit the possible range of interferent concentrations. The same kind of expert knowledge allows improved (lower mean squared error, MSE) analyte determinations also in "classical" multichannel measurements if those are intractable due to perfect collinearity or to high noise inflation. To achieve this goal bias variance tradeoff is employed, hence there remains some bias in the results and therefore the concept of single channel selectivity can be extended in a natural way to multichannel measurements. This extended definition and the resulting selectivity measure can also be applied to the so-called inverse multivariate methods like partial least squares regression (PLSR), principal component regression (PCR) and ridge regression (RR).

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“…A resposta obtida deve corresponder exclusivamente ao analito. 27 A seletividade foi avaliada para a metodologia empregada, comparando-se dois grupos de amostras: um contendo a matriz (urina) e outro, no qual a matriz está ausente, ambos com concentrações de analito idênticas em cada nível de concentração de interesse.…”

Section: Seletividadeunclassified