Selective α1A-blocker improves bladder storage function in rats via suppression of C-fiber afferent activity

Yokoyama, Osamu; Ito, Hiroki; Aoki, Yoshitaka; Oyama, Nobuyuki; Miwa, Yoshiji; Akino, Hironobu

doi:10.1007/s00345-009-0481-2

Cited by 42 publications

(29 citation statements)

References 16 publications

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“…It has been shown that suppression of afferent nerve activity with neurotoxins, such as botulinum toxin and resiniferatoxin, effectively relieves OAB symptoms in both human patients (Schurch et al 2000;Silva et al 2002) and animal models (Atiemo et al 2005;Khera et al 2005;Yokoyama et al 2005Yokoyama et al , 2010, emphasizing the importance of afferent nerve dynamics in the pathogenesis of OAB.…”

Section: Modulation Of Afferent Fibres By Pgementioning

confidence: 99%

Modulation of afferent nerve activity by prostaglandin E₂ upon urinary bladder distension in rats

Kuga¹,

Tanioka²,

Hagihara³

et al. 2016

Experimental Physiology

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New Findings r What is the central question of this study?It has been widely assumed that C fibres innervating the bladder are mainly excited in overactive bladder syndrome. However, it remains unclear whether Aδ fibres are also activated in pathological conditions. r What is the main finding and its importance?We found that a certain population of Aδ fibres, which become active specifically at a bladder pressure of more than 15 cmH 2 O in normal conditions, showed increased excitability in conditions of prostaglandin E 2 -induced overactive bladder. This result suggests that a certain population of Aδ fibres, together with C fibres, triggers pathophysiological activity.In overactive bladder syndrome, afferent C fibres innervating the bladder show an increased activity level. However, it remains unclear whether all C fibres are highly activated and whether Aδ fibres, the other type of bladder afferent fibre, are also involved in pathological conditions. To address these questions, we analysed the relationship between bladder pressure and single-unit firing patterns of afferent nerves in the left L6 dorsal roots in living rats. The recorded fibres were classified as Aδ fibres or C fibres based on the response to 0.3 μm tetrodotoxin. Certain populations of both Aδ fibres and C fibres were activated at bladder pressures below 15 cmH 2 O (classified as low-threshold fibres), indicating their potential contribution to detection of normal bladder filling. Intravesical administration of prostaglandin E 2 (PGE 2 ) induced hyperexcitation in approximately half of such C fibres, whereas the activity patterns of low-threshold Aδ fibres were unchanged. All fibres, regardless of type, which were almost silent in control conditions (classified as high-threshold fibres), were activated by application of PGE 2 . Notably, the firing patterns of Aδ fibres, rather than C fibres, were highly time locked to PGE 2 -induced micro-oscillation of bladder pressure. These modulatory effects of PGE 2 on Aδ fibres and C fibres might trigger pathophysiological activity together in overactive bladder syndrome.

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Section: Modulation Of Afferent Fibres By Pgementioning

confidence: 99%

Modulation of afferent nerve activity by prostaglandin E₂ upon urinary bladder distension in rats

Kuga¹,

Tanioka²,

Hagihara³

et al. 2016

Experimental Physiology

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“…Oyama et al. more recently also demonstrated better improvements in IPSS score with silodosin vs. tamsulosin or naftopidil up to 9 months after BT 95. Shimizu et al., however, demonstrated that the effects of silodosin are temporary in a 12‐month follow‐up study of 105 patients given sildonosin daily for 6 months immediately after BT 96.…”

Section: Discussionmentioning

confidence: 86%

Integrative review on the non‐invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies

et al. 2015

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SummaryAimTo develop a non‐invasive management strategy for men with lower urinary tract symptoms (LUTS) after treatment for pelvic cancer, that is suitable for use in a primary healthcare context.MethodsPubMed literature searches of LUTS management in this patient group were carried out, together with obtaining a consensus of management strategies from a panel of authors for the management of LUTS from across the UK.ResultsData from 41 articles were investigated and collated. Clinical experience was sought from authors where there was no clinical evidence. The findings discussed in this paper confirm that LUTS after the cancer treatment can significantly impair men's quality of life. While many men recover from LUTS spontaneously over time, a significant proportion require long‐term management. Despite the prevalence of LUTS, there is a lack of consensus on best management. This article offers a comprehensive treatment algorithm to manage patients with LUTS following pelvic cancer treatment.ConclusionBased on published research literature and clinical experience, recommendations are proposed for the standardisation of management strategies employed for men with LUTS after the pelvic cancer treatment. In addition to implementing the algorithm, understanding the rationale for the type and timing of LUTS management strategies is crucial for clinicians and patients.

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“…Finally, this binding induces an increase in the intracellular calcium levels and smooth muscle contraction [15]. The main cause of LUTS in BPH is prostate contraction that is predominantly mediated by alpha1A-AR [16,17]. Therefore, the blockage of α1A adrenoreceptors results in prostatic and urethral smooth muscle relaxation and may improve the voiding symptoms.…”

Section: Discussionmentioning

confidence: 99%

A Study on Efficacy and Safety of Silodosin in Geriatric Patients with Benign Prostatic Hyperplasia

Praneeth¹,

T.P²,

Bhandary³

et al. 2017

IOSR JDMS

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Selective α1A-blocker improves bladder storage function in rats via suppression of C-fiber afferent activity

Abstract: These results suggest that the α(1A)-AR subtype activates C-fiber afferents, and that consequently α(1A)-blockade can improve bladder storage function.

Cited by 42 publications

References 16 publications

Modulation of afferent nerve activity by prostaglandin E₂ upon urinary bladder distension in rats

Modulation of afferent nerve activity by prostaglandin E₂ upon urinary bladder distension in rats

Integrative review on the non‐invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies

A Study on Efficacy and Safety of Silodosin in Geriatric Patients with Benign Prostatic Hyperplasia

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Selective α1A-blocker improves bladder storage function in rats via suppression of C-fiber afferent activity

Abstract: These results suggest that the α(1A)-AR subtype activates C-fiber afferents, and that consequently α(1A)-blockade can improve bladder storage function.

Cited by 42 publications

References 16 publications

Modulation of afferent nerve activity by prostaglandin E2 upon urinary bladder distension in rats

Modulation of afferent nerve activity by prostaglandin E2 upon urinary bladder distension in rats

Integrative review on the non‐invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies

A Study on Efficacy and Safety of Silodosin in Geriatric Patients with Benign Prostatic Hyperplasia

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Modulation of afferent nerve activity by prostaglandin E₂ upon urinary bladder distension in rats

Modulation of afferent nerve activity by prostaglandin E₂ upon urinary bladder distension in rats