Selective α<sub>1A</sub>-Adrenoceptor Stimulation Induces Mueller’s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation

Yano, Shiharu; Hirose, Masao; Nakada, Tsutomu; Nakayama, Jun; Matsuo, Kiyoshi; Yamada, Mitsuhiko

doi:10.3109/02713680903518858

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…Each of the 50 patients with CTTH raised his or her chin and gazed downward while in the supine position; the upper eyelid was then pinched for 60 seconds to detach it from the globe and create a space in the upper fornix. Two-to-three drops of 5% phenylephrine (an a1-selective agonist) were administered into the space [9,22], which ensured that the phenylephrine was retained by gravity in the area to stimulate only unilateral Müller's smooth muscle fibres. Before (Figure 4a, d) and 5 minutes after administration of phenylephrine (Figure 4b, e), the surface electromyographic activities of the bilateral frontalis muscles on primary gaze in the 50 patients with CTTH were integrated and compared statistically (Table I, Figure 4g).…”

Section: Electromyographic Analysis Of the Frontalis And Occipitalis mentioning

confidence: 99%

Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis

Matsuo

Ban

2012

Journal of Plastic Surgery and Hand Surgery

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Proprioceptively innervated intramuscular connective tissues in Müller's muscle function as exterior mechanoreceptors to induce reflex contraction of the levator and occipitofrontalis muscles. In aponeurotic blepharoptosis, since the levator aponeurosis is disinserted from the tarsus, stretching of the mechanoreceptors in Müller's muscle is increased even on primary gaze to induce phasic and tonic reflexive contraction of the occipitofrontalis muscle. It was hypothesised that in certain patients with aponeurotic blepharoptosis, the presence of tonic reflexive contraction of the occipitofrontalis muscle due to the sensitised mechanoreceptors in Müller's muscle, can cause chronic tension-type headache (CTTH) associated with occipitofrontalis tenderness. To verify this hypothesis, this study evaluated (1) what differentiates patients with CTTH from patients without CTTH, (2) how pharmacological contraction of Müller's smooth muscle fibres as a method for desensitising the mechanoreceptors in Müller's muscle affects electromyographic activity of the frontalis muscle, and (3) how surgical aponeurotic reinsertion to desensitise the mechanoreceptors in Müller's muscle electromyographically or subjectively affects activities of the occipitofrontalis muscle or CTTH. It was found that patients had sustained CTTH when light eyelid closure did not markedly reduce eyebrow elevation. However, pharmacological contraction of Müller's smooth muscle fibres or surgery to desensitise the mechanoreceptor electromyographically reduced the tonic contraction of the occipitofrontalis muscle on primary gaze and subjectively relieved aponeurotic blepharoptosis-associated CTTH. Over-stretching of the mechanoreceptors in Müller's muscle on primary gaze may induce CTTH due to tonic reflexive contraction of the occipitofrontalis muscle. Therefore, surgical desensitisation of the mechanoreceptors in Müller's muscle appears to relieve CTTH.

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Section: Electromyographic Analysis Of the Frontalis And Occipitalis mentioning

confidence: 99%

Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis

Matsuo

Ban

2012

Journal of Plastic Surgery and Hand Surgery

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“…In a canine upper eyelid model, Yano et al. demonstrated that a selective α1A-adrenoceptor agonist indeed led to sustained Mueller muscle contraction similar to the effect of phenylephrine ( 11 ). A predominance of α1-receptors was also confirmed histopathologically in human ptotic eyelid specimens ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Apraclonidine—An eye opener

et al. 2022

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Pharmacological testing with apraclonidine eye drops induces a typical reversal of anisocoria in patients with Horner’s syndrome. Moreover, apraclonidine was observed to have an elevating effect on the upper eyelid in Horner’s syndrome as well as in healthy subjects, which is thought to be mediated by alpha-1 adrenergic receptors present in the Muller’s muscle. We aim to quantitatively investigate the effect of apraclonidine on eyelid position in patients with Horner’s syndrome compared to physiological anisocoria based on infrared video recordings from pupillometry. We included 36 patients for analysis who underwent binocular pupillometry before and after apraclonidine 1% testing for the evaluation of anisocoria. Vertical eyelid measurements were taken from infrared videos and averaged from multiple pupillometry cycles. Receiver operating characteristic curves were calculated to determine the optimal cutoff value for change in eyelid aperture pre- and post-apraclonidine. A decrease of inter-eye difference in the aperture of >0.42 mm was discriminative of Horner’s syndrome compared to physiological anisocoria with a sensitivity of 80% and a specificity of 75%. Our data confirm an eyelid- elevating effect of the apraclonidine test, more pronounced in eyes with a sympathetic denervation deficit. Measuring eyelid aperture on pupillometry recordings may improve the diagnostic accuracy of apraclonidine testing in Horner’s syndrome.

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Measurements of oculo-palpebral landmarks and evaluation of patient’s head position

Sirinturk,

Govsa,

Coban

et al. 2024

Surg Radiol Anat

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Selective α_1A-Adrenoceptor Stimulation Induces Mueller’s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation

Cited by 7 publications

References 24 publications

Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis

Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis

Apraclonidine—An eye opener

Measurements of oculo-palpebral landmarks and evaluation of patient’s head position

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Selective α1A-Adrenoceptor Stimulation Induces Mueller’s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation

Cited by 7 publications

References 24 publications

Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis

Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis

Apraclonidine—An eye opener

Measurements of oculo-palpebral landmarks and evaluation of patient’s head position

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Selective α_1A-Adrenoceptor Stimulation Induces Mueller’s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation