Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation

Boetto, Julien; Apra, Caroline; Bielle, Franck; Peyre, Matthieu; Kalamaridès, Michel

doi:10.1038/s41388-018-0328-7

Cited by 30 publications

(23 citation statements)

References 31 publications

(44 reference statements)

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“…For example, in meningioma, the most common intracranial tumor in the United States, rare HH pathway mutations are found in tumors with excellent clinical outcomes (138,139). Nevertheless, constitutive activation of SMO in the meninges fails to cause meningioma in most mice, suggesting that HH misactivation is not sufficient to induce or drive meningioma growth (140).…”

Section: Hedgehog Signaling In Other Cancersmentioning

confidence: 99%

Misactivation of Hedgehog signaling causes inherited and sporadic cancers

Raleigh¹,

Reiter²

2019

Journal of Clinical Investigation

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Section: Hedgehog Signaling In Other Cancersmentioning

confidence: 99%

Misactivation of Hedgehog signaling causes inherited and sporadic cancers

Raleigh¹,

Reiter²

2019

Journal of Clinical Investigation

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“…The role of each of these genes and molecules is still being elucidated (e.g. [6]), as they represent possible therapeutic targets. FOXM1 , for instance, has been associated with worse clinical outcome as a marker for aggressive meningioma [52].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome signatures associated with meningioma progression

Viaene

Zhang

Martinez‐Lage

et al. 2019

acta neuropathol commun

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Meningiomas are the most common primary brain tumor of adults. The majority are benign (WHO grade I), with a mostly indolent course; 20% of them (WHO grade II and III) are, however, considered aggressive and require a more complex management. WHO grade II and III tumors are heterogeneous and, in some cases, can develop from a prior lower grade meningioma, although most arise de novo. Mechanisms leading to progression or implicated in de novo grade II and III tumorigenesis are poorly understood. RNA-seq was used to profile the transcriptome of grade I, II, and III meningiomas and to identify genes that may be involved in progression. Bioinformatic analyses showed that grade I meningiomas that progress to a higher grade are molecularly different from those that do not. As such, we identify GREM2 , a regulator of the BMP pathway, and the snoRNAs SNORA46 and SNORA48 , as being significantly reduced in meningioma progression. Additionally, our study has identified several novel fusion transcripts that are differentially present in meningiomas, with grade I tumors that did not progress presenting more fusion transcripts than all other tumors. Interestingly, our study also points to a difference in the tumor immune microenvironment that correlates with histopathological grade. Electronic supplementary material The online version of this article (10.1186/s40478-019-0690-x) contains supplementary material, which is available to authorized users.

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“…Meningiomas originate from the meningothelial cells at the dural-arachnoid junction (12) and tend to grow along with the meningeal layer of the dura (13,14), so the meningeal architecture plays an essential role in determining the potential extending pathway and selecting appropriate surgical maneuvers for resection ACMs (15). In the present study, we used a novel morphological technology, the epoxy sheet plastination in combination with the confocal microscopy, to identify and trace the meningeal layers around the ACP and reveal their precise relationship with surrounding structures, e.g., the ICA, cranial nerves, and cavernous sinus ( Figure 1F).…”

Section: Discussion Meningeal Architecture-based Classification Of Acmsmentioning

confidence: 99%

Anterior Clinoidal Meningiomas: Meningeal Anatomical Considerations and Surgical Implications

Yan

Evins

et al. 2020

Front. Oncol.

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Surgical removal of anterior clinoidal meningiomas (ACMs) remains a challenge because of its complicated relationship with surrounding meninges, major arteries and cranial nerves. This study aims to define the meningeal structures around the anterior clinoid process (ACP) and its surgical implications. Methods: Five dry skulls and 19 cadavers were used in the anatomical study. Cadavers were prepared as transverse, coronal, and sagittal plastinated sections, and the meningeal architecture around the ACP was studied with dissecting and confocal microscopies. The database of meningiomas in one single center was retrospectively reviewed, and the patients with ACMs were collected for clinical analysis. Results: The superior, lateral, medial surfaces, and the tip of ACP were covered by different layers and types of meninges. The ACMs were classified into four main types based on the sites of origin, possible extending pathways following meningeal dura. In the retrospective cohort of 131 ACMs, the percentage of types I, IIa, IIb, III, and IV were 42.0% (55/131), 19.8% (26/131), 9.2% (12/131), 16.8% (22/131), and 12.2% (16/131), respectively. We found that types IIa and I had higher chances for achieving Simpson grade 1-2 resection (92.3 and 85.4%, respectively), followed by type III (54.5%) and type IV (31.3%), while type IIb showed little chance of Simpson grade 1-2 resection. Univariate and multivariate analyses revealed ACM classification and tumor size (<3 cm) to be independent risk factors for achieving more extensive resection. Conclusion: The meningeal architecture around the ACP may guide and determine the origin and extension of ACMs. The classification based on the meningeal architecture helps to understand surgical anatomy as well as predicting surgical outcomes.

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Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation

Cited by 30 publications

References 31 publications

Misactivation of Hedgehog signaling causes inherited and sporadic cancers

Misactivation of Hedgehog signaling causes inherited and sporadic cancers

Transcriptome signatures associated with meningioma progression

Anterior Clinoidal Meningiomas: Meningeal Anatomical Considerations and Surgical Implications

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