Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes

Klatzmann, David; Barré‐Sinoussi, Françoise; Nugeyre, Marie-Thérèse; Danquet, C; Vilmer, E; Griscelli, C; Brun-Veziret, F; Rouzioux, Christine; Gluckman, Jean Claude; Chermann, J.-C.

doi:10.1126/science.6328660

Cited by 893 publications

(334 citation statements)

References 21 publications

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“…The conditions for superimposed CMV disease during HIV infection differ from those in bone marrow transplant recipients in that the immunosuppression selectively affects the CD4+ T lymphocytes, while sparing the CD8+ T lymphocytes (18) .…”

mentioning

confidence: 99%

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Jonjić

Mutter

Weiland

et al. 1989

The Journal of Experimental Medicine

520

339

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We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.

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mentioning

confidence: 99%

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Jonjić

Mutter

Weiland

et al. 1989

The Journal of Experimental Medicine

520

339

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“…The virus infects and damages both CD4 [2] and antigen-processing eells [3]. The upshot of these effects is anergy to skin test antigens [4], low lymphocyte proiiferative responses to both mitogens and antigens, together with impaired production of cytokines [5], and poor control of viral [6] and bacterial pathogens such as Mycobacterium tuberculosis [7] and Streptococcus pneumoniae [8].…”

Section: Introductionmentioning

confidence: 99%

Immunological responses of Gambians in relation to clinical stage of HIV-2 disease

Whittle

Egboga

Todd

et al. 1993

Clinical and Experimental Immunology

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SUMMARYThis study describes a broad spectrum of cellular and antibody-mediated immune responses found in 28 asymptomatic and 37 symptomatic Gambian patients with HIV-2 infection. It shows that these responses vary according to the stage of infection as described by three clinical staging systems. The first system was a local one based on the signs used for the WHO Bangui clinical definition of AIDS, the second, suggested by WHO, was based on a performance scale, and the third was that used by the Centre for Disease Control. Asymptomatic patients had significantly lower mean CD4 counts, lymphoproliferative and interferon-gamma (IFN-y) responses and lower IgG and IgM antibody responses to keyhole limpet haemocyanin (KLH) than controls. These measurements and the size of the skin test reaction to purified protein derivative (PPD) or Candida antigen declined significantly according to the stage of infection. Mean values of the serological markers (82-microglobulin and neopterin and antibody titres to Epstein-Barr virus capsid antigen (EBVCA) rose significantly according to severity of disease. The Gambian or WHO clinical staging systems, which are easy and cheap to apply, may serve as an alternative to sophisticated and expensive immunological measurements when trying to stage disease and prediet prognosis.

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“…Similar to HIV infection of humans, infection with SIV causes an AIDS-like disease in the majority of infected macaques (30). SIV and HIV are also similar in that both have tropism for CD4 ϩ T cells (31,32) and that structurally diverse HIV and SIV envelope glycoproteins use similar members of the chemokine receptor family as coreceptors (33,34). Furthermore, HLA-A and -B locus homologues are found in rhesus macaques (21), and both human and macaque (Macaca mulatta) MHC class I (Mamu) 3 molecules appear to bind gag and env epitopes from similar regions of both HIV and SIV (35).…”

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confidence: 99%

Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques

Dzuris¹,

Sidney²,

Appella

et al. 2000

The Journal of Immunology

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Since the onset of the HIV pandemic, the use of nonhuman primate models of infection has increasingly become important. An excellent model to study HIV infection and immunological responses, in particular cell-mediated immune responses, is SIV infection of rhesus macaques. CTL epitopes have been mapped using SIV-infected rhesus macaques, but, to date, a peptide binding motif has been described for only one rhesus class I MHC molecule, Mamu-A*01. Herein, we have established peptide-live cell binding assays for four rhesus MHC class I molecules: Mamu-A*11, -B*03, -B*04, and -B*17. Using such assays, peptide binding motifs have been established for all four of these rhesus MHC class I molecules. With respect to the nature and spacing of crucial anchor positions, the motifs defined for Mamu-B*04 and -B*17 present unique features not previously observed for other primate species. The motifs identified for Mamu-A*11 and -B*03 are very similar to the peptide binding motifs previously described for human HLA-B*44 and -B*27, respectively. Accordingly, naturally processed peptides derived from HLA-B*44 and HLA-B*27 specifically bind Mamu-A*11 and Mamu-B*03, respectively, indicating that conserved MHC class I binding capabilities exist between rhesus macaques and humans. The definition of four rhesus MHC class I-specific motifs expands our ability to accurately detect and quantitate immune responses to MHC class I-restricted epitopes in rhesus macaques and to rationally design peptide epitope-based model vaccine constructs destined for use in nonhuman primates.

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Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes

Cited by 893 publications

References 21 publications

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Immunological responses of Gambians in relation to clinical stage of HIV-2 disease

Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques

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