Selective Thromboxane A2Synthase Inhibition by OKY-046 Prevents Cardiopulmonary Dysfunction after Ovine Smoke Inhalation Injury

Abstract

These findings suggest that selective thromboxane A2 synthase inhibition may represent a goal-directed therapeutic approach to alleviate cardiovascular and pulmonary dysfunction in the setting of smoke inhalation injury.

QTc Interval and Neurological Outcomes in Aneurysmal Subarachnoid Hemorrhage

“…Ozagrel, selective thromboxane A2 CI confidence interval, GCS Glasgow Coma Scale, T3 7 day after operation, QTc interval heart rate-corrected QT interval CI confidence interval, GCS Glasgow Coma Scale, T3 7 day after operation, QTc interval heart rate-corrected QT interval synthase inhibitor, ameliorates platelet aggregation, vascular constriction, and brain edema in acute cerebral ischemia [36]. Fasudil, rho-kinase inhibitor, improves hemodynamic function by increasing regional cerebral blood flow, preventing hyperviscosity, and upregulating endothelial nitric oxide synthase activity in endothelial cells [37]. These drugs do not have the cardiac side effects in clinical use.…”

Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep

“…Using an established and clinically relevant ovine model of acute respiratory distress syndrome (11)(12)(13)(14)(15)(16)(17), the present study evaluated the regulatory role of nNOS in the common setting of combined burn and smoke inhalation in- jury. The major findings were a) that nNOS-derived NO is critically involved in the pathogenesis of cardiopulmonary dysfunctions related to this form of acute respiratory distress syndrome and b) that selective nNOS inhibition with 7-NI markedly reduced the inflammatory response, thereby attenuating the degree of injury, without obvious side effects.…”

“…After a baseline measurement, sheep were randomly allocated to 1) healthy controls (sham), 2) injured controls (burn and smoke ϭ B/S control), or 3) an injured intervention group undergoing nNOS inhibition (7-NI, n ϭ 7 each). The animals belonging to groups 2 and 3 were subjected to combined burn and smoke inhalation injury (40% third degree flame burn; 4 ϫ 12 breaths of cold cotton smoke) using an established protocol (13)(14)(15)(16). Sheep randomized to the sham or B/S control group received only the vehicle of 7-NI.…”

Protective Role of Simvastatin on Lung Damage Caused by Burn and Cotton Smoke Inhalation in Rats

“…The majority of studies in experimental animals have employed large animals, such as sheep, where the animal is anesthetized, and smoke is introduced by mechanical ventilation [8,9]. Although use of these animals has contributed much to our understanding of smoke inhalation injury, they are too costly to use routinely to screen potential therapeutic modalities that may benefit the smoke inhalation patient.…”