Selective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate

Abstract

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo­[2,1-b]­thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo­[4,5]­imidazo­[2,1-b]­thiazoles and thiazoles in satisfactory yields.

Electrochemical single-step N-acylation and S-cyclization synthesis of thiazolimide via radical process

“…In 2021, our group found that using a metal catalyst, with the promotion of iodine under O 2 , we could obtain thiazolimide derivatives as by-products in modest yields. 37 Pharmaceutical researchers have showed great interest in green approaches for the development of medicinal products. 38 In recent decades continuous attempts have been made to incorporate green strategies in the synthesis of thiazole and its derivatives (Fig.…”

“…In 2021, our group found that using a metal catalyst, with the promotion of iodine under O 2 , we could obtain thiazolimide derivatives as by-products in modest yields. 37…”

Multisite-Sequential Cyclization To Construct 1,2,4-Triazole-Based N-Fused Heterocyclics

“…The construction of functional fused heterocycles and the combination of thiocyanation with other elementary reactions to generate multirings has been the focus of our research for many years . Thiocyanate, which is commercially available, serves as an odorless, atom-economic, and multifunctional source of sulfur, nitrogen, and bridge carbon.…”

Photoinduced Synthesis of Thiocyanates through Hydrogen Atom Transfer and One-Pot Derivatization to Isothiocyanates

“…Thiocyanates are widely used as intermediates in synthetic chemistry. For instance, thiocyanates easily transform into thiols, disulfides, trifluoromethyl thioethers, carbamodithioates, and various heterocycles . Thiocyanate-containing natural products have been reported to be involved in the mechanism of DNA damage. , Thus, thiocyanates are attracting the broad interest of many chemists and biologists.…”