Abstract:Background and Aims
Crohn’s disease is a debilitating chronic inflammatory disorder of the mammalian gastrointestinal tract. Current interventions using anti-TNF biologics show long term benefit in only half of patients. This study focused on the role of the TNF receptor 1 (TNFR1) in pathogenesis in a TNF-driven model of ileitis.
Methods
We studied TNF ΔAU-rich element (ARE)/+ (TNFdARE) mice, which develop progressive ileitis… Show more
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