Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: Total remission in Yoshida sarcoma-bearing rats

Widder, Kenneth J.; Morris, Robert; Poore, Gerald A.; Howard, Donald P.; Senyei, Andrew E.

doi:10.1016/0277-5379(83)90408-x

Cited by 137 publications

(50 citation statements)

References 7 publications

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“…These additional advantages come from such specific properties of magnetic nanoparticles as magnetic responsiveness and MRI visibility. Several investigators have previously shown that magnetic nanoparticles can be retained at tumor sites, after local administration combined with a locally applied external magnetic field, due to the "magnetic responsiveness" of the iron oxide core, thereby enabling magnetic targeting [27][28][29][30]. Additionally, it has also been demonstrated that detectable amounts of magnetic nanoparticles are able to reach the tumor of 9L-glioma bearing rats after intravenous administration [31,32].…”

Section: Introductionmentioning

confidence: 99%

Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors

et al. 2008

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This study explored the possibility of utilizing iron oxide nanoparticles as a drug delivery vehicle for minimally invasive, MRI-monitored magnetic targeting of brain tumors. In vitro determined hydrodynamic diameter of ~100nm, saturation magnetization of 94 emu/g Fe and T 2 relaxivity of 43 s −1 mM −1 of the nanoparticles suggested their applicability for this purpose. In vivo effect of magnetic targeting on the extent and selectivity of nanoparticle accumulation in tumors of rats harboring orthotopic 9L-gliosarcomas was quantified with MRI. Animals were intravenously injected with nanoparticles (12 mg Fe/kg) under a magnetic field density of 0 T (control) or 0.4 T (experimental) applied for 30 minutes. MR images were acquired prior to administration of nanoparticles and immediately after magnetic targeting at 1 hour intervals for 4 hours. Image analysis revealed that magnetic targeting induced a 5-fold increase in the total glioma exposure to magnetic nanoparticles over non-targeted tumors (p=0.005) and a 3.6-fold enhancement in the target selectivity index of nanoparticle accumulation in glioma over the normal brain (p=0.025). In conclusion, accumulation of iron oxide nanoparticles in gliosarcomas can be significantly enhanced by magnetic targeting and successfully quantified by MR imaging. Hence, these nanoparticles appear to be a promising vehicle for glioma-targeted drug delivery.

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Section: Introductionmentioning

confidence: 99%

Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors

et al. 2008

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“…Widder 31 , et al first published their results of using magnetic albumin microspheres to target cytotoxic drugs (doxorubicin) in sarcoma (tumor) bearing rats. Since then the engineered biocompatible nanoparticle carriers have been considerably developed for imaging and for delivering drugs to specific target sites in vivo as well as for hyperthermia.…”

Section: Core-shell Nanoparticlesmentioning

confidence: 99%

A Novel Method for the Synthesis of Core-shell Magnetic Nanoparticle

Mukherji

2016

Def. Sc. Jl.

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<p>Core-shell type magnetic nanoparticles are finding attractive applications in biomedicine, from diagnostic to cancer therapy. Both for targeted drug delivery and hyperthermia, as well as a contrast agent used for external biomedical imaging systems, small (< 20 nm) superparamagnetic nanoparticles are desired. Some iron oxide nanoparticle formulations are already approved for human administration as contrast agent for magnetic resonance imaging. However, search continues for nanoparticles with higher saturation magnetisation. Metallic, bi-metallic and intermetallic magnetic nanoparticles are finding attention. Biocompatibility and optimal clearance are important criteria for the medical applications and therefore core-shell type particles are favored, where a biocompatible shell (e.g. polymer, Silica) can prevent inadvertent host reaction with the magnetic core. A recently developed novel synthesis method (electrochemical selective phase dissolution - ESPD), which can produce core-shell magnetic nanoparticles, is reviewed in this paper. ESPD, as the name suggests, uses electro-chemical separation of a phase from metallic alloys to synthesize nanoparticles. It is a versatile method and can be adopted to produce a wide range of nanostructures in addition to the core-shell magnetic nanoparticles.</p>

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“…The SPION can either be inserted directly into the tumor or a tumor-supplying artery with a syringe or a punch, or injected into a peripheral vein and then trapped at the tumor site with a magnetic field from outside. [5][6][7] An additional alternating magnetic field may be used to generate heat in the tumor tissue through Néel and Brownian relaxation with the consequence that the thermosensitive layer melts and the drug is released at the tumor site. 8 Nonetheless, for the development of our model, we focused on the accumulation of the SPION and did not deal with the application of the alternating magnetic field.…”

mentioning

confidence: 99%

“…9,10 Examples for the application of extracorporeal magnets can be found in the study by Widder et al who treated a sarcoma at a rat's tail, or the study by Alexiou who used pole shoes to treat tumors. 6,11,12 However, the injection near the tumor without application of magnetic fields is not sufficient for SPION accumulation, because over 50% of SPION are cleared through the liver after a couple of minutes as shown by Lübbe et al 7 The targeting of the SPION and the local drug release remains an unsolved problem for tumors and organs located interior in the body. We hypothesize that a sufficient magnetic field to accumulate the SPION in internal tumors can be reached, if the magnet accumulating the nanoparticles is placed endoscopically in close neighborhood to the tumor.…”

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confidence: 99%

Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment

Roeth

Slabu

Baumann

et al. 2017

IJN

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Superparamagnetic iron oxide nanoparticles (SPION) may be used for local tumor treatment by coupling them to a drug and accumulating them locally with magnetic field traps, that is, a combination of permanent magnets and coils. Thereafter, an alternating magnetic field generates heat which may be used to release the thermosensitively bound drug and for hyperthermia. Until today, only superficial tumors can be treated with this method. Our aim was to transfer this method into an endoscopic setting to also reach the majority of tumors located inside the body. To find the ideal endoscopic magnetic field trap, which accumulates the most SPION, we first developed a biophysical model considering anatomical as well as physical conditions. Entities of choice were esophageal and prostate cancer. The magnetic susceptibilities of different porcine and rat tissues were measured with a superconducting quantum interference device. All tissues showed diamagnetic behavior. The evaluation of clinical data (computed tomography scan, endosonography, surgical reports, pathological evaluation) of patients gave insight into the topographical relationship between the tumor and its surroundings. Both were used to establish the biophysical model of the tumors and their surroundings, closely mirroring the clinical situation, in which we could virtually design, place and evaluate different electromagnetic coil configurations to find optimized magnetic field traps for each tumor entity. By simulation, we could show that the efficiency of the magnetic field traps can be enhanced by 38-fold for prostate and 8-fold for esophageal cancer. Therefore, our approach of endoscopic targeting is an improvement of the magnetic drug-targeting setups for SPION tumor therapy as it holds the possibility of reaching tumors inside the body in a minimal-invasive way. Future animal experiments must prove these findings in vivo.

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Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: Total remission in Yoshida sarcoma-bearing rats

Cited by 137 publications

References 7 publications

Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors

Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors

A Novel Method for the Synthesis of Core-shell Magnetic Nanoparticle

Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment

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