Selective targeting of chronic social stress-induced activated neurons identifies neurogenesis-related genes to be associated with resilience in female mice

Guilherme, Malena dos Santos; Tsoutsouli, Theodora; Chongtham, Monika Chanu; Winter, Jennifer; Gerber, Susanne; Müller, Marianne B.

doi:10.1016/j.psyneuen.2022.105700

Cited by 7 publications

(16 citation statements)

References 70 publications

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“…C57BL6/J OlaHsd mice were obtained from Envigo (Horst, The Netherlands) at the age of 3 weeks and subsequently maintained in a 12 h light/dark cycle with food (Ssniff Spezialdiäten GmbH, Soest, Germany) and water available ad libitum in the local facility. ARC-creERT2/+.R26CAG-LSL-Sun1-sfGFP-Myc/+ (hereby termed as Arc-sfGFP, [8]) mice were obtained via in-house breeding from the Johannes Gutenberg University (TARC). This mouse model allows specific Tamoxifen-dependent CRE-recombination under the promoter of the immediate early gene Arc in nuclei activated by stressful events, for example.…”

Section: Animalsmentioning

confidence: 99%

“…Female C57BL6/J OlaHsd and Arc-sfGFP mice were subjected to a social instability paradigm, eliciting stress as measurable by corticosterone elevation or low-frequency ultrasonic calls [8]. Briefly, mice were kept in groups of four from four weeks on, and groups were shuffled two times a week following an algorithm that prevented re-introducing known animals up to week five of the shuffling procedure.…”

Section: Figurementioning

confidence: 99%

“…Tamoxifen injection in female Arc-sfGFP mice (Supplementary Figure S1) was conducted as described in [8]. The procedure for male mice is described in [26].…”

Section: Figurementioning

confidence: 99%

“…The outcome as to whether external threats will lead to disease development or whether an individual stays healthy despite all adversities depends on the resilience of the individual [6]. Many host-allocated factors that regulate or were attributed to resilience such as the inflammasome [7], neurotrophic hippocampal factors [8] or physical activity [9] have already been identified. However, it seems highly plausible that the microbial community of the gastrointestinal system might be one of the factors to be considered.…”

Section: Introductionmentioning

confidence: 99%

“…Within recent years, models for females have also been established, allowing for investigations into their reaction to chronic social stress. The social instability paradigm that we recently published for C57BL6/J mice [8] was used here to compare the effect of CSDS in males with outcome in females: interestingly, an increase in Bacteroides spp. was also noted in stressed female animals, suggesting a potential common mechanism of sex in reaction to chronic social stress.…”

Section: Introductionmentioning

confidence: 99%

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Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice

et al. 2022

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The microbiome is an important player within physiological homeostasis of the body but also in pathophysiological derailments. Chronic social stress is a challenge to the organism, which results in psychological illnesses such as depression in some individuals and can be counterbalanced by others, namely resilient individuals. In this study, we wanted to elucidate the potential contribution of the microbiome to promote resilience. Male mice were subjected to the classical chronic social defeat paradigm. Defeated or undefeated mice were either controls (receiving normal drinking water) or pre-treated with antibiotics or probiotics. Following social defeat, resilient behavior was assessed by means of the social interaction test. Neither depletion nor probiotic-shifted alteration of the microbiome influenced stress-associated behavioral outcomes. Nevertheless, clear changes in microbiota composition due to the defeat stress were observed such as elevated Bacteroides spp. This stress-induced increase in Bacteroides in male mice could be confirmed in a related social stress paradigm (instable social hierarchy) in females. This indicates that while manipulation of the microbiome via the antibiotics- and probiotics-treatment regime used here has no direct impact on modulating individual stress susceptibility in rodents, it clearly affects the microbiome in the second line and in a sex-independent manner regarding Bacteroides.

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Section: Animalsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

“…Tamoxifen injection in female Arc-sfGFP mice (Supplementary Figure S1) was conducted as described in [8]. The procedure for male mice is described in [26].…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice

et al. 2022

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The lifetime impact of stress on fear regulation and cortical function

2023

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Potential resilience treatments for orangutans (Pongo spp.): Lessons from a scoping review of interventions in humans and other animals

Bridgeland-Stephens,

Thorpe,

Chappell

2023

Anim. welf.

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Wild orangutans (Pongo spp.) rescued from human-wildlife conflict must be adequately rehabilitated before being returned to the wild. It is essential that released orangutans are able to cope with stressful challenges such as food scarcity, navigating unfamiliar environments, and regaining independence from human support. Although practical skills are taught to orangutans in rehabilitation centres, post-release survival rates are low. Psychological resilience, or the ability to ‘bounce back’ from stress, may be a key missing piece of the puzzle. However, there is very little knowledge about species-appropriate interventions which could help captive orangutans increase resilience to stress. This scoping review summarises and critically analyses existing human and non-human animal resilience literature and provides suggestions for the development of interventions for orangutans in rehabilitation. Three scientific databases were searched in 2021 and 2023, resulting in 63 human studies and 266 non-human animal studies. The first section brings together human resilience interventions, identifying common themes and assessing the applicability of human interventions to orangutans in rehabilitation. The second section groups animal interventions into categories of direct stress, separation stress, environmental conditions, social stress, and exercise. In each category, interventions are critically analysed to evaluate their potential for orangutans in rehabilitation. The results show that mild and manageable forms of intervention have the greatest potential benefit with the least amount of risk. The study concludes by emphasising the need for further investigation and experimentation, to develop appropriate interventions and measure their effect on the post-release survival rate of orangutans.

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Selective targeting of chronic social stress-induced activated neurons identifies neurogenesis-related genes to be associated with resilience in female mice

Cited by 7 publications

References 70 publications

Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice

Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice

The lifetime impact of stress on fear regulation and cortical function

Potential resilience treatments for orangutans (Pongo spp.): Lessons from a scoping review of interventions in humans and other animals

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