Selective targeting of biting females to control mosquito-borne infectious diseases

Kojin, Bianca Burini; Compton, Austin; Adelman, Zach N.; Tu, Zhijian

doi:10.1016/j.pt.2022.05.012

Cited by 4 publications

(2 citation statements)

References 105 publications

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“…fsRIDL has been utilized to successfully suppress fruit flies 24 , mosquitos 19,[25][26][27][28] , and moths 29,30 in cage or field trials. Nevertheless, fsRIDL still relies on mass-rearing technology, which is costly and demanding in some species 14,25,[31][32][33][34][35] , so it may still often lack the power necessary for success.…”

Section: Introductionmentioning

confidence: 99%

Population suppression by release of insects carrying a dominant sterile homing gene drive targetingdoublesexinDrosophila

Chen

Guo

Liu

et al. 2023

Preprint

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Gene drive alleles, which bias their own inheritance and increase in frequency, show great promise for blocking disease transmission or directly suppressing pest populations. The most common engineered drive system is the CRISPR homing drive, which converts wild-type alleles to drive alleles in the germline of drive heterozygotes by homology-directed repair after CRISPR cleavage. One successful homing drive example targets a female-specific exon in doublesex in Anopheles mosquitos, suppressing the population by inducing recessive sterility in female drive homozygotes. We found that in Drosophila melanogaster, a 3-gRNA drive disrupting the doublesex female exon resulted in a masculine phenotype and dominant female sterility. Resistance alleles formed by end-joining repair were also dominant sterile. This was likely caused by expression of male-specific transcripts in females with drive and resistance alleles, disrupting sex development. Based on this construct, we proposed a new pest suppression system called Release of Insects carrying a Dominant-sterile Drive (RIDD). This entails continuously releasing drive heterozygous males, with drive and resistance alleles causing sterility in females. The drive remains at high frequency longer than currently used dominant female-lethal alleles (RIDL) due to drive conversion in males, and drive alleles also cause sterility based on resistance, both substantial advantages. With weekly releases of drive males into a cage population with overlapping generations, our RIDD system targeting dsx reached 100% prevalence within 27 weeks, progressively reducing egg production and eventually causing total population collapse. RIDD combines the merits of homing gene drive and RIDL. It is powerful but self-limiting, unlike unconfined standard homing drives, allowing for targeted population suppression.

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Section: Introductionmentioning

confidence: 99%

Population suppression by release of insects carrying a dominant sterile homing gene drive targetingdoublesexinDrosophila

Chen

Guo

Liu

et al. 2023

Preprint

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“…aegypti at a calendar date 𝑡 through the four developmental stages of the mosquito lifecycle: egg (𝐸), larva (𝐿), pupa (𝑃), and (female) adult (𝐴). We assumed a 1:1 sex ratio for adult mosquitoes, considering only female adult mosquitoes because males are not epidemiologically important (Kojin et al, 2022;Lounibos & Escher, 2008). Adult female mosquitoes were further classified as susceptible (𝐴 𝑆 ), latent (𝐴 𝐸 ), or infectious (𝐴 𝐼 ) to model DENV transmission through the mosquito population.…”

Section: Mathematical Modeling Analysismentioning

confidence: 99%

Comparing the effectiveness of adulticide application interventions on mitigating local transmission of dengue virus

Kummer,

Wilke,

Ventura

et al. 2024

Preprint

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The southern US has a large presence of mosquito vector species for dengue virus (DENV) and experiences thousands of DENV importations every year, which have led to several local outbreaks. Adulticide spraying targeting active mosquitoes is one of the most common insecticide strategies used as a response to an outbreak. The aim of this study is to evaluate the effectiveness of adulticide spraying conducted at different times of the day to curb DENV transmission. Based on unique dataset dataset of Aedes aegypti diel activity patterns in Miami-Dade County, Florida, and Brownsville, Texas, we developed a mechanistic model of DENV transmission, which simulates adulticide spraying interventions. We estimated that spraying adulticide for 14 consecutive days at 7am or 8pm was highly effective in reducing DENV outbreak probability from 10% in the absence of interventions to 0.1% for Miami-Dade County, and from 7.8% to 0.1% for Brownsville. Moreover, in case of a local outbreak in Miami-Dade County, we estimated the median number of symptomatic infections after the identification of a local outbreak to be reduced from 67.0 (IQR: 25.5-103.0) in the absence of interventions to 1.0 (IQR: 0.0-2.0) when spraying adulticide for 14 consecutive days at 8pm. In Brownsville, the same intervention is estimated to lead to a decrease from 15.0 (IQR: 7.0-33.0) cases to 1.0 (IQR: 0.0-2.0). Our study highlights the importance of considering diel activity patterns of vector mosquito species in arbovirus preparedness and response planning and provide quantitative evidence to guide the decision-making of mosquito control authorities.

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Comparing the effectiveness of adulticide application interventions on mitigating local transmission of dengue virus

Kummer,

Wilke,

Ventura

et al. 2024

J Pest Sci

View full text Add to dashboard Cite

The southern US has a large presence of mosquito vector species for dengue virus (DENV) and experiences thousands of DENV importations every year, which have led to several local outbreaks. Adulticide spraying targeting active mosquitoes is one of the most common insecticide strategies used as a response to an outbreak. The aim of this study is to evaluate the effectiveness of adulticide spraying conducted at different times of the day to curb DENV transmission. Based on unique dataset of Aedes aegypti diel activity patterns in Miami-Dade County, Florida, and Brownsville, Texas, we developed a mechanistic model of DENV transmission, which simulates adulticide spraying interventions. We estimated that spraying adulticide for 14 consecutive days at 7am or 8 pm was highly effective in reducing DENV outbreak probability from 10% in the absence of interventions to 0.1% for Miami-Dade County, and from 7.8 to 0.1% for Brownsville. Moreover, in case of a local outbreak in Miami-Dade County, we estimated the median number of symptomatic infections after the identification of a local outbreak to be reduced from 67.0 (IQR: 25.5–103.0) in the absence of interventions to 1.0 (IQR: 0.0–2.0) when spraying adulticide for 14 consecutive days at 8 pm. In Brownsville, the same intervention is estimated to lead to a decrease from 15.0 (IQR: 7.0–33.0) cases to 1.0 (IQR: 0.0–2.0). Our study highlights the importance of considering diel activity patterns of vector mosquito species in arbovirus preparedness and response planning and provide quantitative evidence to guide the decision-making of mosquito control authorities.

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Selective targeting of biting females to control mosquito-borne infectious diseases

Cited by 4 publications

References 105 publications

Population suppression by release of insects carrying a dominant sterile homing gene drive targetingdoublesexinDrosophila

Population suppression by release of insects carrying a dominant sterile homing gene drive targetingdoublesexinDrosophila

Comparing the effectiveness of adulticide application interventions on mitigating local transmission of dengue virus

Comparing the effectiveness of adulticide application interventions on mitigating local transmission of dengue virus

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