Selective spectrophotometric determination of p-aminophenol and acetaminophen

Mohamed, Fardous A.; Abdallah, Mohamed Adel; Shammat, Soad M.

doi:10.1016/s0039-9140(96)02013-9

Cited by 119 publications

(52 citation statements)

References 16 publications

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“…These methods involves two stages oxidation of the drug by NBS and the estimation of unconsumed NBS with Celestine blue (CB). Some drugs can be directly determined with NBS in acidic (30,31) or alkaline (32)(33)(34)(35) media and the color formed is determined spectrophotometrically. Potentiometric method involves the direct titration of drug with NBS in acidic medium is rare in the literature (36) .…”

Section: Cefprozilmentioning

confidence: 99%

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

2010

Egypt. J. Chem.

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WO SIMPLE, accurate spectrophotometric and potentiometric m methods were developed for the determination of cefprozil, dropropizine and tizanidine hydrochloride in their pharmaceutical preparations. The spectrophotometric method is based on the selective oxidation of cefprozil or tizanidine with N-bromosuccinimide in an alkaline medium to give an intense yellow product with a maximum absorption at 396 or 384 nm, respectively. The reaction conditions were studied and optimized. The reaction obeyed Beer's law over the concentration range 5-40 and 10-80 g ml -1 for cefprozil and tizanidine hydrochloride, respectively. The potentiometric method involves the direct titration of cefprozil and dropropizine with Nbromosuccinimide in sulphuric acid medium and the end point is determined potentiometrically using platinum electrode. Cefprozil and dropropizine can be determined quantitatively in the concentration range of 0.13-1.30 and 0.118-1.180 mg with recovery values of 98.46-100.77 and 99.58-100.85% and relative standard deviations 0.39-0.54 and 0.52-0.87% for cefprozil and dropropizine, respectively. The proposed methods are applied for the determination of these drugs in pure forms and in pharmaceutical preparations.

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Section: Cefprozilmentioning

confidence: 99%

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

2010

Egypt. J. Chem.

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“…Spectrophotometric determination of paracetamol in drug ©IJRASET (UGC Approved Journal): All Rights are Reserved formulation has been a subject of several investigators. [34][35][36][37][38][39][40][41][42] In this paper it has been tried to consolidate the various work done on the well-known drug that finds extensive application in pharmaceutical industries in the last few decades. Paracetamol (4-hydroxyacetanilide or acetmidophenol) is a well known drug that is having extensive appliction in pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic properties and Mechanism of Aquachloro iridium (III) Catalyzed Oxidation of Pharmaceutical drug (Paracetamol) by Acidic solution of Potassium Bromate (KBrO3): A kinetic study

Patel¹

2018

IJRASET

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“…Spectrophotometric determination of paracetamol in drug formulations has been the subject of several investigators [1][2][3][4][5][6][7][8]. Generally, the same principle, that is, oxidation of paracetamol by metal ion oxidants, has been used for the estimation of paracetamol.…”

Section: Introductionmentioning

confidence: 99%

The Study of Influence of the Teslar Technology on Aqueous Solution of Some Biomolecules

2011

Physical Chemistry

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The kinetics of paracetamol oxidation are first order each in [paracetamol] and [HClO 4 ]. The kinetic study shows that the oxidation proceeds in two steps. The effects of anionic micelles of sodiumdodecyl sulphate (SDS) and complexing agents (ethylenediammine tetraacetic acid (EDTA) and 2,2 -bipyridyl (bpy)) were also studied. Fast kinetic spectrophotometric method has been described for the determination of paracetamol. The method is based on the catalytic effect of manganese(II) on the oxidation of paracetamol by chromium(VI) in the presence of HClO 4 (= 0.23 mol dm −3 ). Optimum reaction time is 4 to 6 minutes at a temperature of 30• C. The addition of manganese(II) ions largely decreased the absorbance of chromium(VI) at 350 nm. This reaction can be utilized for the determination of paracetamol in drugs.

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Selective spectrophotometric determination of p-aminophenol and acetaminophen

Cited by 119 publications

References 16 publications

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

Thermodynamic properties and Mechanism of Aquachloro iridium (III) Catalyzed Oxidation of Pharmaceutical drug (Paracetamol) by Acidic solution of Potassium Bromate (KBrO3): A kinetic study

The Study of Influence of the Teslar Technology on Aqueous Solution of Some Biomolecules

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