Selective spectrofluorimetric method for the determination of perindopril erbumine in bulk and tablets through derivatization with dansyl chloride

Abstract

Background: Perindopril erbumine is an antihypertensive, which belongs to the category of angiotensin-converting enzyme inhibitors (ACE inhibitors) that inhibit the conversion of angiotensin I to angiotensin II. Methods: A new, selective, and sensitive spectrofluorimetric method was developed for the determination of perindopril erbumine based on the reaction with dansyl chloride in alkaline medium to give a highly fluorescent derivative which was measured at 496 nm after excitation at 340 nm in dichloromethane. The reaction conditions were studied and optimized.

Selective Spectrofluorimetric Approach for the Assessment of Two Antipsychotic Drugs through Derivatization with O-Phthalaldehyde

“…As a luminous derivatizing reagent for amino-containing compounds, o -phthalaldehyde in conjunction with a mercapto molecule, such as β-mercaptoethanol, is commonly used. Several medicinal molecules have been identified using this method [ 36 , 37 , 38 , 39 , 40 ]. In the presence of β-mercaptoethanol in a borate buffer, ARP and CLZ reacted with benzene-1,2-dicarboxaldehyde to generate a strongly fluorescent compound with maximal fluorescence at 450 nm following excitation at 340 nm ( Figure 1 ).…”

Utilization of erythrosine B in spectrofluorimetric quenching analysis of amlodipine and perindopril in pharmaceutical and biological matrices

“…Perindopril (PER) is an antihypertensive nonsulfhydryl angiotensin‐converting enzyme (ACE) inhibitor that is used to treat hypertension and stable coronary artery disease with the nomenclature of (2 S ,3 aS ,7 aS )‐1‐[(2 S )‐2‐[[(2 S )‐1‐ethoxy‐1‐oxopentan‐2‐yl]amino]propanoyl]‐2,3,3 a ,4,5,6,7,7 a ‐octahydroindole‐2‐carboxylic acid (Figure 1b). For determining PER alone or in combination, various analytical procedures have been published including spectrophotometry [3, 4, 7, 8, 43–45], spectrofluorimetry [46–49], and chromatographic approaches including TLC [30], LC–MS/MS [31] and HPLC [4, 34–36, 39, 50, 51].…”

“…The approach was simple, sensitive, and validated according to International Council on Harmonization (ICH) guidelines. The proposed method had higher sensitivity than many of the previously reported methods [19, 20, 23, 25, 28, 46–49]. In addition, some of the reported methods required elevated temperature, were time consuming, and were carried out in the presence of concentrated acids [28, 49].…”

“…For determining PER alone or in combination, various analytical procedures have been published including spectrophotometry [3,4,7,8,[43][44][45], spectrofluorimetry [46][47][48][49], and chromatographic approaches including TLC [30], LC-MS/MS [31] and HPLC [4, 34-36, 39, 50, 51].…”

Spectrofluorimetric assay of amlodipine and perindopril in their raw materials, pharmaceutical formulations and spiked human plasma through the formation of complexes with Eosin Y

“…1-b). For determination of PER alone or in combination, a variety of analytical techniques have been reported including spectrophotometric techniques (El-Bagary et al 2016;Hegazy et al 2015;Karadurmuş et al 2018;Magdy et al 2018;Rahman et al 2017;Saad et al 2016;Siridevi et al 2019), spectrofluorimetric techniques (Al-Haj Sakur et al 2015Fael and Sakur 2015a, b;Sakur et al 2015) and chromatographic techniques including TLC-densitometry (Patel et al 2020a, b), LC-MS/MS (Rezk and Badr 2020) and HPLC (Duraisamy and Jaganathan 2017;Hassan et al 2020;Hemdan et al 2018;Karadurmuş et al 2018;Naik et al 2020;Patel et al 2020a, b;Saleh et al 2020).…”