Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.

Song, Fujian; Freemantle, Nick; Sheldon, Trevor; House, Allan; Watson, Paul; Long, Andrew; Mason, James

doi:10.1136/bmj.306.6879.683

Cited by 361 publications

(181 citation statements)

References 43 publications

(28 reference statements)

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“…10,11,9,20 Although metaanalyses have demonstrated at least small improvements in therapy continuation from SSRI use relative to TCAs and heterocyclics 12 and significant improvement from SSRI use relative to TCAs excluding heterocyclics, 10,11,9 others have shown no difference in therapy discontinuation between SSRIs and TCAs. 21 One meta-analysis has documented differences in meta-analytic results depending on location of clinical trials; comparisons of all trials and United States-only trials found a trend towards lower discontinuation rates with SSRIs relative to TCAs.…”

Section: Implications For Further Researchmentioning

confidence: 99%

Antidepressant treatment for depression: total charges and therapy duration

Dobrez

Melfi

Croghan

et al. 2000

J Ment Health Policy Econ

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Background: The economic costs of depression are significant, both the direct medical costs of care and the indirect costs of lost productivity. Empirical studies of antidepressant costeffectiveness suggest that the use of selective serotonin reuptake inhibitors (SSRIs) may be no more costly than tricyclic antidepressants (TCAs), will improve tolerability, and is associated with longer therapy duration. However the success of depression care usually involves multiple factors, including source of care, type of care, and patient characteristics, in addition to drug choice. The cost-effective mix of antidepressant therapy components is unclear.

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Section: Implications For Further Researchmentioning

confidence: 99%

Antidepressant treatment for depression: total charges and therapy duration

Dobrez

Melfi

Croghan

et al. 2000

J Ment Health Policy Econ

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“…However, SSRIs are not proven to be as effective as TCAs in hospitalized patients (21). Several meta-analysis studies reported little difference in efficacy among the different classes of antidepressants (22,23); the prescribing rates for SSRIs were the highest as these drugs are better tolerated with significantly lower rates of treatment discontinuations overall and due to fewer side effects (24,25 …”

Section: Discussionmentioning

confidence: 99%

Analysis of antidepressant prescribing tendencies in Lithuania in 2003–2004

Jakimavičius¹,

Sveikata

Vainauskas³

et al. 2007

Medicina

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“…Premature attrition results in the loss of outcome data from as many as 30% (Anderson and Tomenson, 1994;Hotopf et al, 1997;Montgomery et al, 1994;Song et al, 1993) of the subjects enrolled in an RCT. There is also a tendency for differential attrition of subjects.…”

Section: Randomized Controlled Trials In the Comparison Of Antidepresmentioning

confidence: 99%

“…Perhaps the most influential example of meta-analyses in mood disorders research is the series by Anderson, Freemantle, and colleagues, which demonstrated that SSRIs are, as a class, comparably effective and significantly better tolerated than TCAs (Anderson, 1998(Anderson, , 2000Anderson and Tomenson, 1994;Song et al, 1993). They also allowed for the detection of differences in subgroup comparisons not apparent in qualitative reviews or single primary studies.…”

Section: Chronology Of Meta-analysis In Antidepressant Researchmentioning

confidence: 99%

Comparing the Effects of Antidepressants: Consensus Guidelines for Evaluating Quantitative Reviews of Antidepressant Efficacy

Lieberman

Greenhouse

Hamer

et al. 2005

Neuropsychopharmacol

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With increasing numbers of treatment options available for patients with major depression over the last decade and the growing body of evidence describing their efficacy and safety, clinicians often find it difficult to determine the best and most appropriate evidence-based treatment for each patient. Systematic reviews utilizing statistical methods that synthesize and evaluate data from a number of studies have become increasingly more available over the past decade. We review major findings and lessons learned from salient examples of quantitative analyses of antidepressant research and provide recommendations for meta-analysts, journal and grant reviewers, and research 'consumers' (ie, clinicians) for conducting, reporting, and evaluating such analyses.

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Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.

Cited by 361 publications

References 43 publications

Antidepressant treatment for depression: total charges and therapy duration

Antidepressant treatment for depression: total charges and therapy duration

Analysis of antidepressant prescribing tendencies in Lithuania in 2003–2004

Comparing the Effects of Antidepressants: Consensus Guidelines for Evaluating Quantitative Reviews of Antidepressant Efficacy

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