Selective Serotonin Reuptake Inhibitors Decrease Impulsive Behavior as Measured by an Adjusting Delay Procedure in the Pigeon

Wolff, Mary C.; Leander, J. David

doi:10.1016/s0893-133x(02)00307-x

Cited by 47 publications

(41 citation statements)

References 27 publications

(34 reference statements)

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“…Dogs with higher DIAS scores tolerate lower maximum delays, preferring smaller, more immediate rewards. This is supported by previous studies which relate higher levels of impulsivity to reduced ability to tolerate delay of reinforcement [23], [26], [52].…”

Section: Discussionsupporting

confidence: 85%

“…These results are reflected in findings with primates, where lower levels of CSF 5-HIAA have been found in relation to impulsive aggression [33], social impulsivity [34] and impulsive "risk taking" behaviour [33], [35], [36]. Other studies demonstrating the link between 5-HT and impulsive behaviour involve pharmacological manipulations [23], and lesions of the 5-HT pathways [37] [38].…”

Section: Accepted M Manuscriptmentioning

confidence: 80%

“…It has also been used as the primary outcome variable by other authors using a similar paradigm in other species [23]. Indeed MaxD was highly correlated with five of the other measures of performance within the task (Table 3).…”

Section: Delayed Reward Choice Testmentioning

confidence: 96%

“…Laboratory models of impulsivity in non human animals also tend to focus on response inhibition and delayed reward paradigms [19]. Response inhibition models assess the subject"s ability to inhibit responding [20], [21], [22], and delayed reward models measure an animal"s choice between a small, immediate reinforcer, and a large, delayed reinforcer, assessing "impulsive choice", an index of impulsivity [23], [24]. Van den Bergh et al [25] investigated the relationship between response inhibition and delay aversion in rats, suggesting that response inhibition and delay aversion are independent measures of impulsivity, consistent with previous findings in humans [18].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…In line with the work of [23], the maximum delay reached on the large-delayed device at the end of the 15 minute choice test (MaxD) was considered the primary measure of "impulsive choice", where a higher maximum delay is considered less impulsive (more self controlled) and a lower maximum delay is considered more impulsive.…”

Section: Accepted M Manuscript 10mentioning

confidence: 99%

See 4 more Smart Citations

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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Impulsivity is a trait related to inhibitory control which is expressed in a range of behaviours. Impulsive individuals show a decreased ability to tolerate delay of reinforcement, and more impulsive behaviour has been linked to decreased levels of serotonin and dopamine in a number of species. In domestic dogs, impulsivity is implicated in problem behaviours that result from a lack of self control, but currently there are no published studies that assess behavioural and physiological measures of impulsivity in relation to this trait. Impulsivity scores were calculated for 41 dogs using an owner-report assessment, the Dog Impulsivity Assessment Scale (DIAS).Twenty-three of these subjects completed an operant choice task based on a delayed reward paradigm, to assess their tolerance to delay of reinforcement. High Pressure Liquid Chromatography (HPLC) with Fluorometric Detection was used to detect levels of the metabolites of serotonin (5-HIAA) and dopamine (HVA) in the urine of 17 of the subjects. Higher impulsivity scores were found to be significantly correlated with more impulsive behaviour (reduced tolerance to delay of reinforcement) in the behaviour tests and lower levels of urinary 5-HIAA and 5-HIAA/HVA ratio. The results demonstrate convergent validity between impulsivity (as assessed by the DIAS) and behavioural and physiological parameters.

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Section: Discussionsupporting

confidence: 85%

Section: Accepted M Manuscriptmentioning

confidence: 80%

Section: Delayed Reward Choice Testmentioning

confidence: 96%

Section: Accepted M Manuscriptmentioning

confidence: 99%

Section: Accepted M Manuscript 10mentioning

confidence: 99%

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Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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Choice

Mazur¹,

Fantino²

2014

The Wiley Blackwell Handbook of Operant and Classical Conditioning

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Serotonin function is associated with behavioral response to a novel conspecific in marmosets

et al. 2006

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The function of the central nervous system neurotransmitter serotonin (5-HT) contributes to individual differences in impulsive behavior in humans and nonhuman primates. We investigated the relationship between 5-HT function and behavioral responses to a novel social scenario in marmosets. In the first study, marmosets (n=10) were treated orally with fluoxetine HCl (FLX) or vehicle for two trial periods and exposed to a novel conspecific for a 20-min trial following each treatment. Levels of behavioral inhibition in response to a novel conspecific were quantified. The animals exhibited less inhibition toward the novel conspecific following the 14-day FLX treatment than they did following the vehicle treatment. In the second study we first characterized the parameters of the marmoset peripheral 5-HT system and further assessed the relationship between natural variation in peripheral 5-HT and 5-HIAA levels with behavioral inhibition in response to a novel conspecific (n=14). Individual peripheral 5-HT and 5-HIAA levels were higher in animals that exhibited more inhibition in response toward the stranger. We conclude that serotonergic influences play a role in behavioral response to a novel conspecific in marmosets.

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Selective Serotonin Reuptake Inhibitors Decrease Impulsive Behavior as Measured by an Adjusting Delay Procedure in the Pigeon

Abstract: The inability to delay gratification (reinforcement orreward

Cited by 47 publications

References 27 publications

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Choice

Serotonin function is associated with behavioral response to a novel conspecific in marmosets

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