Selective serotonin re-uptake inhibitors (SSRIs) for preventing migraine and tension-type headaches

Moja, Lorenzo; Cusi, Cristina; Sterzi, Roberto; Canepari, C

doi:10.1002/14651858.cd002919.pub2

Cited by 97 publications

(77 citation statements)

References 58 publications

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“…It is clear that serotonin has a role in pain mechanisms, and specifically serotonin hyper production is accompanied by tension headache and migraine pain. 18 An association exists between maternal stress and PTD. 19,20 Moreover, corticotropin-releasing hormone has been proposed as the placental clock and patients with elevated corticotropinreleasing hormone concentrations (that may results from any stress including environmental) delivered preterm.…”

Section: Discussionmentioning

confidence: 99%

The influence of meteorological factors on the emergence of preterm delivery and preterm premature rupture of membrane

2008

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Objective: To evaluate the influence of changes in the atmospheric state on the incidence of preterm delivery (PTD) and preterm premature rupture of membrane (PPROM).Study Design: The hospital records of PTD and/or PPROM over the year 1999 were reviewed. The current meteorological state was described by a set of parameters and their diurnal and seasonal variations. Multivariate analysis, time series approach and Poisson regression were used.Result: PTD occurrence was correlated with humidity and maximum temperature (P<0.01), its rise preceded their sharp variations by 3 days (P<0.01). PPROM was influenced by the variations in the weather state: desert heat wave arrival (P ¼ 0.093), strong winds, overall daily differences of humidity and temperature (all with P<0.05). Conclusion:The rates of PTD and PPROM are affected by an ensemble of meteorological variables, specific for each disorder. Obstetricians should be aware of the influence of unstable weather on PTD and PPROM rates, especially in the spring and autumn.

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Section: Discussionmentioning

confidence: 99%

The influence of meteorological factors on the emergence of preterm delivery and preterm premature rupture of membrane

2008

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“…Meta-analysis of studies of tension type headache prophylaxis with oral treatment provide conflicting results: a lack of superiority of antidepressant medication or myorelaxants over placebo is reported in one study [53], and a beneficial effect of tricyclic antidepressants in two others [54,55]. No data are presented to evaluate a putative placebo effect.…”

Section: Prophylactic Treatment and Placebo Effectmentioning

confidence: 99%

“…No data are presented to evaluate a putative placebo effect. Interestingly, the follow-up of four groups of patients with chronic tension-type headache [54] treated with anti-depressant medication or placebo with or without stress-management therapy, showed that the placebo had a non-different effect compared to the anti-depressant medication or stress-management therapy given alone on headache activity in the sub-group with initial low CTTH severity and on disability in the sub-group without initial mood and anxiety disorders [56]. This part of the data raises the issue of the placebo efficacy in CTTH of low severity.…”

Section: Prophylactic Treatment and Placebo Effectmentioning

confidence: 99%

Placebo and other psychological interactions in headache treatment

Autret

Valade

Debiais

et al. 2012

Deutsche Zeitschrift für Akupunktur

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We present a theory according which a headache treatment acts through a specific biological effect (when it exists), a placebo effect linked to both expectancy and repetition of its administration (conditioning), and a nonspecific psychological effect. The respective part of these components varies with the treatments and the clinical situations. During antiquity, suggestions and beliefs were the mainstays of headache treatment. The word placebo appeared at the beginning of the eighteenth century. Controversies about its effect came from an excessive interpretation due to methodological bias, inadequate consideration of the variation of the measure (regression to the mean) and of the natural course of the disease. Several powerful studies on placebo effect showed that the nature of the treatment, the associated announce, the patients' expectancy, and the repetition of the procedures are of paramount importance. The placebo expectancy is associated with an activation of pre-frontal, anterior cingular, accumbens, and periacqueducal grey opioidergic neurons possibly triggered by the dopaminergic meso-limbic system. In randomized control trials, several arms design could theoretically give information concerning the respective part of the different component of the outcome and control the natural course of the disease. However, for migraine and tension type headache attacks treatment, no three arm (verum, placebo, and natural course) trial is available in the literature. Indirect evidence of a placebo effect in migraine attack treatment, comes from the high amplitude of the improvement observed in the placebo arms (28% of the patients). This figure is lower (6%) when using the harder criterium of pain free at 2 h. But these data disregard the effect of the natural course. For prophylactic treatment with oral medication, the trials performed in the last decades report an improvement in 21% of the patients in the placebo arms. However, in these studies the duration of administration was limited, the control of attacks uncertain as well as the evolution of the co-morbid psychopathology. Considering the reviews and meta-analysis of complex prophylactic procedures, it must be concluded that their effect is mostly linked to a placebo and non-specific psychological effects. Acupuncture may have a slight specific effect on tension type headache, but not on migraine. Manual therapy studies do not exhibit difference between manipulation, mobilization, and controls; touch has no proven specific effect. A comprehensive efficacy review of biofeedback studies concludes to a small specific effect on tension type headache but not on migraine. A review of behavioral treatment conclude to an interesting mean improvement but did not demonstrated a specific effect with the exception of a four arm study including a pseudo meditation control group. Expectation-linked placebo, conditioning, and non-specific psychological effects vary according clinical situations and psychological context; likely low in RCT, high after anempathic...

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“…39 In migraine or tension type headache, meta-analysis has shown that SSRIs do not adequately reduce headache global severity index compared with placebo after 8 weeks of treatment. 107 Also, none of the outcome measures (main outcome measures such as headache frequency, severity, duration and secondary outcome measures such as tolerability, use of other analgesics, quality of life and mood) favored SSRIs. However, given the limitations of the available studies (small sample sizes, short follow-up duration, methodological limitations), there is a need to further investigate the effects of SSRIs in these conditions.…”

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confidence: 99%

Efficacy of Antidepressants as Analgesics: A Review

Dharmshaktu¹,

Tayal²,

Kalra³

2012

The Journal of Clinical Pharma

274

189

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Persistent pain disorders are usually not adequately alleviated by nonsteroidal anti‐inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy for the control of persistent pain is currently being practiced in disorders such as fibromyalgia, neuropathic pain, rheumatoid conditions, low back pain, and headache. This review describes the various mechanisms of analgesic activity of antidepressants along with their efficacy and tolerability profiles. Meta‐analyses and clinical studies of these agents were retrieved through the use of MEDLINE, Google scholar, and Cochrane databases. Antidepressants are effective in both neuropathic and non‐neuropathic pain and have diverse mechanisms independent of their antidepressant effects. Tricyclic antidepressants (amitryptiline, nortryptiline, desipramine) are effective compounds in the treatment of neuropathic pain, fibromyalgia, low back pain, and headaches. Studies are ongoing for the dual serotonin norepinephrine reuptake inhibitors (duloxetine, venlafaxine) in several persistent pain conditions and these may be recommended in neuropathic pain, migraines, and fibromyalgia. Evidence suggests that although the analgesic effects of selective serotonin reuptake inhibitors (fluoxetine, paroxetine, citalopram) are limited and inconsistent, yet they have a superior tolerability profile compared with tricyclic antidepressants.

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Selective serotonin re-uptake inhibitors (SSRIs) for preventing migraine and tension-type headaches

Cited by 97 publications

References 58 publications

The influence of meteorological factors on the emergence of preterm delivery and preterm premature rupture of membrane

The influence of meteorological factors on the emergence of preterm delivery and preterm premature rupture of membrane

Placebo and other psychological interactions in headache treatment

Efficacy of Antidepressants as Analgesics: A Review

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